PRDX5

Peroxiredoxin 5, also known as PRDX5, is a human gene.cite web | title = Entrez Gene: PRDX5 peroxiredoxin 5| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=25824| accessdate = ]

PBB_Summary
section_title =
summary_text = This gene encodes a member of the peroxiredoxin family of antioxidant enzymes, which reduce hydrogen peroxide and alkyl hydroperoxides. The encoded protein may play an antioxidant protective role in different tissues under normal conditions and during inflammatory processes. This protein interacts with peroxisome receptor 1. The crystal structure of this protein in its reduced form has been resolved to 1.5 angstrom resolution. This gene uses alternate in-frame translation initiation sites to generate mitochondrial or peroxisomal/cytoplasmic forms. Three transcript variants encoding distinct isoforms have been identified for this gene.cite web | title = Entrez Gene: PRDX5 peroxiredoxin 5| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=25824| accessdate = ]

References

Further reading

PBB_Further_reading
citations =
*cite journal | author=Wood ZA, Schröder E, Robin Harris J, Poole LB |title=Structure, mechanism and regulation of peroxiredoxins. |journal=Trends Biochem. Sci. |volume=28 |issue= 1 |pages= 32–40 |year= 2003 |pmid= 12517450 |doi=
*cite journal | author=Hochstrasser DF, Frutiger S, Paquet N, "et al." |title=Human liver protein
journal=Electrophoresis |volume=13 |issue= 12 |pages= 992–1001 |year= 1993 |pmid= 1286669 |doi=
*cite journal | author=Kropotov A, Sedova V, Ivanov V, "et al." |title=A novel human DNA-binding protein with sequence similarity to a subfamily of redox proteins which is able to repress RNA-polymerase-III-driven transcription of the Alu-family retroposons in vitro. |journal=Eur. J. Biochem. |volume=260 |issue= 2 |pages= 336–46 |year= 1999 |pmid= 10095767 |doi=
*cite journal | author=Wattiez R, Hermans C, Bernard A, "et al." |title=Human bronchoalveolar lavage fluid: two-dimensional gel electrophoresis, amino acid microsequencing and identification of major proteins. |journal=Electrophoresis |volume=20 |issue= 7 |pages= 1634–45 |year= 1999 |pmid= 10424490 |doi= 10.1002/(SICI)1522-2683(19990601)20:7<1634::AID-ELPS1634>3.0.CO;2-J |doilabel=10.1002/(SICI)1522-2683(19990601)20:71634::AID-ELPS16343.0.CO;2-J
*cite journal | author=Yamashita H, Avraham S, Jiang S, "et al." |title=Characterization of human and murine PMP20 peroxisomal proteins that exhibit antioxidant activity in vitro. |journal=J. Biol. Chem. |volume=274 |issue= 42 |pages= 29897–904 |year= 1999 |pmid= 10514471 |doi=
*cite journal | author=Knoops B, Clippe A, Bogard C, "et al." |title=Cloning and characterization of AOEB166, a novel mammalian antioxidant enzyme of the peroxiredoxin family. |journal=J. Biol. Chem. |volume=274 |issue= 43 |pages= 30451–8 |year= 1999 |pmid= 10521424 |doi=
*cite journal | author=Zhou Y, Kok KH, Chun AC, "et al." |title=Mouse peroxiredoxin V is a thioredoxin peroxidase that inhibits p53-induced apoptosis. |journal=Biochem. Biophys. Res. Commun. |volume=268 |issue= 3 |pages= 921–7 |year= 2000 |pmid= 10679306 |doi= 10.1006/bbrc.2000.2231
*cite journal | author=Seo MS, Kang SW, Kim K, "et al." |title=Identification of a new type of mammalian peroxiredoxin that forms an intramolecular disulfide as a reaction intermediate. |journal=J. Biol. Chem. |volume=275 |issue= 27 |pages= 20346–54 |year= 2000 |pmid= 10751410 |doi= 10.1074/jbc.M001943200
*cite journal | author=Hu RM, Han ZG, Song HD, "et al." |title=Gene expression profiling in the human hypothalamus-pituitary-adrenal axis and full-length cDNA cloning. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=97 |issue= 17 |pages= 9543–8 |year= 2000 |pmid= 10931946 |doi= 10.1073/pnas.160270997
*cite journal | author=Declercq JP, Evrard C, Clippe A, "et al." |title=Crystal structure of human peroxiredoxin 5, a novel type of mammalian peroxiredoxin at 1.5 A resolution. |journal=J. Mol. Biol. |volume=311 |issue= 4 |pages= 751–9 |year= 2001 |pmid= 11518528 |doi= 10.1006/jmbi.2001.4853
*cite journal | author=Rouhier N, Gelhaye E, Jacquot JP |title=Glutaredoxin-dependent peroxiredoxin from poplar: protein-protein interaction and catalytic mechanism. |journal=J. Biol. Chem. |volume=277 |issue= 16 |pages= 13609–14 |year= 2002 |pmid= 11832487 |doi= 10.1074/jbc.M111489200
*cite journal | author=Wang MX, Wei A, Yuan J, "et al." |title=Expression and regulation of peroxiredoxin 5 in human osteoarthritis. |journal=FEBS Lett. |volume=531 |issue= 2 |pages= 359–62 |year= 2002 |pmid= 12417342 |doi=
*cite journal | author=Strausberg RL, Feingold EA, Grouse LH, "et al." |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899
*cite journal | author=Leyens G, Donnay I, Knoops B |title=Cloning of bovine peroxiredoxins-gene expression in bovine tissues and amino acid sequence comparison with rat, mouse and primate peroxiredoxins. |journal=Comp. Biochem. Physiol. B, Biochem. Mol. Biol. |volume=136 |issue= 4 |pages= 943–55 |year= 2004 |pmid= 14662316 |doi=
*cite journal | author=Banmeyer I, Marchand C, Verhaeghe C, "et al." |title=Overexpression of human peroxiredoxin 5 in subcellular compartments of Chinese hamster ovary cells: effects on cytotoxicity and DNA damage caused by peroxides. |journal=Free Radic. Biol. Med. |volume=36 |issue= 1 |pages= 65–77 |year= 2004 |pmid= 14732291 |doi= 10.1016/j.freeradbiomed.2003.10.019
*cite journal | author=Salmon M, Dedessus Le Moutier J, Wenders F, "et al." |title=Role of the PLA2-independent peroxiredoxin VI activity in the survival of immortalized fibroblasts exposed to cytotoxic oxidative stress. |journal=FEBS Lett. |volume=557 |issue= 1-3 |pages= 26–32 |year= 2004 |pmid= 14741336 |doi=
*cite journal | author=Evrard C, Capron A, Marchand C, "et al." |title=Crystal structure of a dimeric oxidized form of human peroxiredoxin 5. |journal=J. Mol. Biol. |volume=337 |issue= 5 |pages= 1079–90 |year= 2004 |pmid= 15046979 |doi= 10.1016/j.jmb.2004.02.017
*cite journal | author=Yuan J, Murrell GA, Trickett A, "et al." |title=Overexpression of antioxidant enzyme peroxiredoxin 5 protects human tendon cells against apoptosis and loss of cellular function during oxidative stress. |journal=Biochim. Biophys. Acta |volume=1693 |issue= 1 |pages= 37–45 |year= 2004 |pmid= 15276323 |doi= 10.1016/j.bbamcr.2004.04.006
*cite journal | author=Dubuisson M, Vander Stricht D, Clippe A, "et al." |title=Human peroxiredoxin 5 is a peroxynitrite reductase. |journal=FEBS Lett. |volume=571 |issue= 1-3 |pages= 161–5 |year= 2004 |pmid= 15280035 |doi= 10.1016/j.febslet.2004.06.080

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