CUGBP1


CUGBP1

CUG triplet repeat, RNA binding protein 1, also known as CUGBP1, is a human gene.cite web | title = Entrez Gene: CUGBP1 CUG triplet repeat, RNA binding protein 1| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=10658| accessdate = ]

PBB_Summary
section_title =
summary_text = Members of the CELF/BRUNOL protein family contain two N-terminal RNA recognition motif (RRM) domains, one C-terminal RRM domain, and a divergent segment of 160-230 aa between the second and third RRM domains. Members of this protein family regulate pre-mRNA alternative splicing and may also be involved in mRNA editing, and translation. This gene may play a role in myotonic dystrophy type 1 (DM1) via interactions with the dystrophia myotonica-protein kinase (DMPK) gene. Alternative splicing results in multiple transcript variants encoding different isoforms.cite web | title = Entrez Gene: CUGBP1 CUG triplet repeat, RNA binding protein 1| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=10658| accessdate = ]

References

Further reading

PBB_Further_reading
citations =
*cite journal | author=Timchenko LT, Timchenko NA, Caskey CT, Roberts R |title=Novel proteins with binding specificity for DNA CTG repeats and RNA CUG repeats: implications for myotonic dystrophy. |journal=Hum. Mol. Genet. |volume=5 |issue= 1 |pages= 115–21 |year= 1996 |pmid= 8789448 |doi=
*cite journal | author=Bhagwati S, Ghatpande A, Leung B |title=Identification of two nuclear proteins which bind to RNA CUG repeats: significance for myotonic dystrophy. |journal=Biochem. Biophys. Res. Commun. |volume=228 |issue= 1 |pages= 55–62 |year= 1996 |pmid= 8912635 |doi= 10.1006/bbrc.1996.1615
*cite journal | author=Timchenko LT, Miller JW, Timchenko NA, "et al." |title=Identification of a (CUG)n triplet repeat RNA-binding protein and its expression in myotonic dystrophy. |journal=Nucleic Acids Res. |volume=24 |issue= 22 |pages= 4407–14 |year= 1997 |pmid= 8948631 |doi=
*cite journal | author=Roberts R, Timchenko NA, Miller JW, "et al." |title=Altered phosphorylation and intracellular distribution of a (CUG)n triplet repeat RNA-binding protein in patients with myotonic dystrophy and in myotonin protein kinase knockout mice. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=94 |issue= 24 |pages= 13221–6 |year= 1998 |pmid= 9371827 |doi=
*cite journal | author=Michalowski S, Miller JW, Urbinati CR, "et al." |title=Visualization of double-stranded RNAs from the myotonic dystrophy protein kinase gene and interactions with CUG-binding protein. |journal=Nucleic Acids Res. |volume=27 |issue= 17 |pages= 3534–42 |year= 1999 |pmid= 10446244 |doi=
*cite journal | author=Timchenko NA, Welm AL, Lu X, Timchenko LT |title=CUG repeat binding protein (CUGBP1) interacts with the 5' region of C/EBPbeta mRNA and regulates translation of C/EBPbeta isoforms. |journal=Nucleic Acids Res. |volume=27 |issue= 22 |pages= 4517–25 |year= 1999 |pmid= 10536163 |doi=
*cite journal | author=Good PJ, Chen Q, Warner SJ, Herring DC |title=A family of human RNA-binding proteins related to the Drosophila Bruno translational regulator. |journal=J. Biol. Chem. |volume=275 |issue= 37 |pages= 28583–92 |year= 2000 |pmid= 10893231 |doi= 10.1074/jbc.M003083200
*cite journal | author=Timchenko NA, Cai ZJ, Welm AL, "et al." |title=RNA CUG repeats sequester CUGBP1 and alter protein levels and activity of CUGBP1. |journal=J. Biol. Chem. |volume=276 |issue= 11 |pages= 7820–6 |year= 2001 |pmid= 11124939 |doi= 10.1074/jbc.M005960200
*cite journal | author=Ladd AN, Charlet N, Cooper TA |title=The CELF family of RNA binding proteins is implicated in cell-specific and developmentally regulated alternative splicing. |journal=Mol. Cell. Biol. |volume=21 |issue= 4 |pages= 1285–96 |year= 2001 |pmid= 11158314 |doi= 10.1128/MCB.21.4.1285-1296.2001
*cite journal | author=Timchenko NA, Iakova P, Cai ZJ, "et al." |title=Molecular basis for impaired muscle differentiation in myotonic dystrophy. |journal=Mol. Cell. Biol. |volume=21 |issue= 20 |pages= 6927–38 |year= 2001 |pmid= 11564876 |doi= 10.1128/MCB.21.20.6927-6938.2001
*cite journal | author=Takahashi N, Sasagawa N, Usuki F, "et al." |title=Coexpression of the CUG-binding protein reduces DM protein kinase expression in COS cells. |journal=J. Biochem. |volume=130 |issue= 5 |pages= 581–7 |year= 2002 |pmid= 11686919 |doi=
*cite journal | author=Strausberg RL, Feingold EA, Grouse LH, "et al." |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899
*cite journal | author=Paillard L, Legagneux V, Beverley Osborne H |title=A functional deadenylation assay identifies human CUG-BP as a deadenylation factor. |journal=Biol. Cell |volume=95 |issue= 2 |pages= 107–13 |year= 2004 |pmid= 12799066 |doi=
*cite journal | author=Ebralidze A, Wang Y, Petkova V, "et al." |title=RNA leaching of transcription factors disrupts transcription in myotonic dystrophy. |journal=Science |volume=303 |issue= 5656 |pages= 383–7 |year= 2004 |pmid= 14657503 |doi= 10.1126/science.1088679
*cite journal | author=Ota T, Suzuki Y, Nishikawa T, "et al." |title=Complete sequencing and characterization of 21,243 full-length human cDNAs. |journal=Nat. Genet. |volume=36 |issue= 1 |pages= 40–5 |year= 2004 |pmid= 14702039 |doi= 10.1038/ng1285
*cite journal | author=Hillman RT, Green RE, Brenner SE |title=An unappreciated role for RNA surveillance. |journal=Genome Biol. |volume=5 |issue= 2 |pages= R8 |year= 2005 |pmid= 14759258 |doi= 10.1186/gb-2004-5-2-r8
*cite journal | author=Baldwin BR, Timchenko NA, Zahnow CA |title=Epidermal growth factor receptor stimulation activates the RNA binding protein CUG-BP1 and increases expression of C/EBPbeta-LIP in mammary epithelial cells. |journal=Mol. Cell. Biol. |volume=24 |issue= 9 |pages= 3682–91 |year= 2004 |pmid= 15082764 |doi=
*cite journal | author=Watanabe T, Takagi A, Sasagawa N, "et al." |title=Altered expression of CUG binding protein 1 mRNA in myotonic dystrophy 1: possible RNA-RNA interaction. |journal=Neurosci. Res. |volume=49 |issue= 1 |pages= 47–54 |year= 2004 |pmid= 15099703 |doi= 10.1016/j.neures.2004.01.008
*cite journal | author=Gerhard DS, Wagner L, Feingold EA, "et al." |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121–7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504
*cite journal | author=Dansithong W, Paul S, Comai L, Reddy S |title=MBNL1 is the primary determinant of focus formation and aberrant insulin receptor splicing in DM1. |journal=J. Biol. Chem. |volume=280 |issue= 7 |pages= 5773–80 |year= 2005 |pmid= 15546872 |doi= 10.1074/jbc.M410781200

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