- FBLN5
Fibulin 5, also known as FBLN5, is a human
gene .cite web | title = Entrez Gene: FBLN5 fibulin 5| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=10516| accessdate = ]PBB_Summary
section_title =
summary_text = The protein encoded by this gene is a secreted, extracellular matrix protein containing an Arg-Gly-Asp (RGD) motif and calcium-binding EGF-like domains. It promotes adhesion of endothelial cells through interaction of integrins and the RGD motif. It is prominently expressed in developing arteries but less so in adult vessels. However, its expression is reinduced in balloon-injured vessels and atherosclerotic lesions, notably in intimal vascular smooth muscle cells and endothelial cells. Therefore, the protein encoded by this gene may play a role in vascular development and remodeling.cite web | title = Entrez Gene: FBLN5 fibulin 5| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=10516| accessdate = ]References
Further reading
PBB_Further_reading
citations =
*cite journal | author=Nakamura T, Ruiz-Lozano P, Lindner V, "et al." |title=DANCE, a novel secreted RGD protein expressed in developing, atherosclerotic, and balloon-injured arteries. |journal=J. Biol. Chem. |volume=274 |issue= 32 |pages= 22476–83 |year= 1999 |pmid= 10428823 |doi=
*cite journal | author=Kowal RC, Jolsin JM, Olson EN, Schultz RA |title=Assignment of fibulin-5 (FBLN5) to human chromosome 14q31 by in situ hybridization and radiation hybrid mapping. |journal=Cytogenet. Cell Genet. |volume=87 |issue= 1-2 |pages= 2–3 |year= 2000 |pmid= 10640802 |doi=
*cite journal | author=Kobayashi M, Hanai R |title=M phase-specific association of human topoisomerase IIIbeta with chromosomes. |journal=Biochem. Biophys. Res. Commun. |volume=287 |issue= 1 |pages= 282–7 |year= 2001 |pmid= 11549288 |doi= 10.1006/bbrc.2001.5580
*cite journal | author=Yanagisawa H, Davis EC, Starcher BC, "et al." |title=Fibulin-5 is an elastin-binding protein essential for elastic fibre development in vivo. |journal=Nature |volume=415 |issue= 6868 |pages= 168–71 |year= 2002 |pmid= 11805834 |doi= 10.1038/415168a
*cite journal | author=Nakamura T, Lozano PR, Ikeda Y, "et al." |title=Fibulin-5/DANCE is essential for elastogenesis in vivo. |journal=Nature |volume=415 |issue= 6868 |pages= 171–5 |year= 2002 |pmid= 11805835 |doi= 10.1038/415171a
*cite journal | author=Kapetanopoulos A, Fresser F, Millonig G, "et al." |title=Direct interaction of the extracellular matrix protein DANCE with apolipoprotein(a) mediated by the kringle IV-type 2 domain. |journal=Mol. Genet. Genomics |volume=267 |issue= 4 |pages= 440–6 |year= 2002 |pmid= 12111551 |doi= 10.1007/s00438-002-0673-6
*cite journal | author=Loeys B, Van Maldergem L, Mortier G, "et al." |title=Homozygosity for a missense mutation in fibulin-5 (FBLN5) results in a severe form of cutis laxa. |journal=Hum. Mol. Genet. |volume=11 |issue= 18 |pages= 2113–8 |year= 2003 |pmid= 12189163 |doi=
*cite journal | author=Strausberg RL, Feingold EA, Grouse LH, "et al." |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899
*cite journal | author=Markova D, Zou Y, Ringpfeil F, "et al." |title=Genetic heterogeneity of cutis laxa: a heterozygous tandem duplication within the fibulin-5 (FBLN5) gene. |journal=Am. J. Hum. Genet. |volume=72 |issue= 4 |pages= 998–1004 |year= 2003 |pmid= 12618961 |doi=
*cite journal | author=Clark HF, Gurney AL, Abaya E, "et al." |title=The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. |journal=Genome Res. |volume=13 |issue= 10 |pages= 2265–70 |year= 2003 |pmid= 12975309 |doi= 10.1101/gr.1293003
*cite journal | author=Liu X, Zhao Y, Gao J, "et al." |title=Elastic fiber homeostasis requires lysyl oxidase-like 1 protein. |journal=Nat. Genet. |volume=36 |issue= 2 |pages= 178–82 |year= 2004 |pmid= 14745449 |doi= 10.1038/ng1297
*cite journal | author=Stone EM, Braun TA, Russell SR, "et al." |title=Missense variations in the fibulin 5 gene and age-related macular degeneration. |journal=N. Engl. J. Med. |volume=351 |issue= 4 |pages= 346–53 |year= 2004 |pmid= 15269314 |doi= 10.1056/NEJMoa040833
*cite journal | author=Gerhard DS, Wagner L, Feingold EA, "et al." |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121–7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504
*cite journal | author=Nguyen AD, Itoh S, Jeney V, "et al." |title=Fibulin-5 is a novel binding protein for extracellular superoxide dismutase. |journal=Circ. Res. |volume=95 |issue= 11 |pages= 1067–74 |year= 2005 |pmid= 15528465 |doi= 10.1161/01.RES.0000149568.85071.FB
*cite journal | author=Wang X, LeMaire SA, Chen L, "et al." |title=Decreased expression of fibulin-5 correlates with reduced elastin in thoracic aortic dissection. |journal=Surgery |volume=138 |issue= 2 |pages= 352–9 |year= 2005 |pmid= 16153447 |doi= 10.1016/j.surg.2005.06.006
*cite journal | author=Otsuki T, Ota T, Nishikawa T, "et al." |title=Signal sequence and keyword trap in silico for selection of full-length human cDNAs encoding secretion or membrane proteins from oligo-capped cDNA libraries. |journal=DNA Res. |volume=12 |issue= 2 |pages= 117–26 |year= 2007 |pmid= 16303743 |doi= 10.1093/dnares/12.2.117
*cite journal | author=Hu Q, Reymond JL, Pinel N, "et al." |title=Inflammatory destruction of elastic fibers in acquired cutis laxa is associated with missense alleles in the elastin and fibulin-5 genes. |journal=J. Invest. Dermatol. |volume=126 |issue= 2 |pages= 283–90 |year= 2006 |pmid= 16374472 |doi= 10.1038/sj.jid.5700047
*cite journal | author=Elahi E, Kalhor R, Banihosseini SS, "et al." |title=Homozygous missense mutation in fibulin-5 in an Iranian autosomal recessive cutis laxa pedigree and associated haplotype. |journal=J. Invest. Dermatol. |volume=126 |issue= 7 |pages= 1506–9 |year= 2006 |pmid= 16691202 |doi= 10.1038/sj.jid.5700247
*cite journal | author=Lim J, Hao T, Shaw C, "et al." |title=A protein-protein interaction network for human inherited ataxias and disorders of Purkinje cell degeneration. |journal=Cell |volume=125 |issue= 4 |pages= 801–14 |year= 2006 |pmid= 16713569 |doi= 10.1016/j.cell.2006.03.032
*cite journal | author=Kuang PP, Joyce-Brady M, Zhang XH, "et al." |title=Fibulin-5 gene expression in human lung fibroblasts is regulated by TGF-beta and phosphatidylinositol 3-kinase activity. |journal=Am. J. Physiol., Cell Physiol. |volume=291 |issue= 6 |pages= C1412–21 |year= 2007 |pmid= 16837650 |doi= 10.1152/ajpcell.00087.2006PBB_Controls
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