SON DNA binding protein, also known as SON, is a human gene.cite web | title = Entrez Gene: SON SON DNA binding protein| url =| accessdate = ]

section_title =
summary_text = The protein encoded by this gene binds to a specific DNA sequence upstream of the upstream regulatory sequence of the core promoter and second enhancer of human hepatitis B virus (HBV). Through this binding, it represses HBV core promoter activity, transcription of HBV genes, and production of HBV virions. The protein shows sequence similarities with other DNA-binding structural proteins such as gallin, oncoproteins of the MYC family, and the oncoprotein MOS. It may also be involved in protecting cells from apoptosis and in pre-mRNA splicing. Several transcript variants encoding different isoforms have been described for this gene, but the full-length nature of only two of them has been determined.cite web | title = Entrez Gene: SON SON DNA binding protein| url =| accessdate = ]


Further reading

citations =
*cite journal | author=Mattioni T, Hume CR, Konigorski S, "et al." |title=A cDNA clone for a novel nuclear protein with DNA binding activity. |journal=Chromosoma |volume=101 |issue= 10 |pages= 618–24 |year= 1992 |pmid= 1424986 |doi=
*cite journal | author=Bliskovskiĭ VV, Berdichevskiĭ FB, Tkachenko AV, "et al." |title= [Coding part of the son gene small transcript contains four areas of complete tandem repeats] |journal=Mol. Biol. (Mosk.) |volume=26 |issue= 4 |pages= 793–806 |year= 1992 |pmid= 1435773 |doi=
*cite journal | author=Bliskovskiĭ VV, Kirillov AV, Zakhar'ev VM, Chumankov IM |title= [The human son gene: the large and small transcripts contains various 5'-terminal sequences] |journal=Mol. Biol. (Mosk.) |volume=26 |issue= 4 |pages= 807–12 |year= 1992 |pmid= 1435774 |doi=
*cite journal | author=Tassone F, Cheng S, Gardiner K |title=Analysis of chromosome 21 yeast artificial chromosome (YAC) clones. |journal=Am. J. Hum. Genet. |volume=51 |issue= 6 |pages= 1251–64 |year= 1993 |pmid= 1463009 |doi=
*cite journal | author=Chumakov IM, Berdichevskiĭ FB, Sokolova NV, "et al." |title= [Identification of a protein product of a novel human gene SON and the biological effect upon administering a changed form of this gene into mammalian cells] |journal=Mol. Biol. (Mosk.) |volume=25 |issue= 3 |pages= 731–9 |year= 1991 |pmid= 1944255 |doi=
*cite journal | author=Berdichevskiĭ FB, Chumakov IM, Kiselev LL |title= [Decoding of the primary structure of the son3 region in human genome: identification of a new protein with unusual structure and homology with DNA-binding proteins] |journal=Mol. Biol. (Mosk.) |volume=22 |issue= 3 |pages= 794–801 |year= 1988 |pmid= 3054499 |doi=
*cite journal | author=Khan IM, Fisher RA, Johnson KJ, "et al." |title=The SON gene encodes a conserved DNA binding protein mapping to human chromosome 21. |journal=Ann. Hum. Genet. |volume=58 |issue= Pt 1 |pages= 25–34 |year= 1994 |pmid= 8031013 |doi=
*cite journal | author=Cheng S, Lutfalla G, Uze G, "et al." |title=GART, SON, IFNAR, and CRF2-4 genes cluster on human chromosome 21 and mouse chromosome 16. |journal=Mamm. Genome |volume=4 |issue= 6 |pages= 338–42 |year= 1993 |pmid= 8318737 |doi=
*cite journal | author=Kikuno R, Nagase T, Ishikawa K, "et al." |title=Prediction of the coding sequences of unidentified human genes. XIV. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. |journal=DNA Res. |volume=6 |issue= 3 |pages= 197–205 |year= 1999 |pmid= 10470851 |doi=
*cite journal | author=Greenhalf W, Lee J, Chaudhuri B |title=A selection system for human apoptosis inhibitors using yeast. |journal=Yeast |volume=15 |issue= 13 |pages= 1307–21 |year= 1999 |pmid= 10509013 |doi= 10.1002/(SICI)1097-0061(19990930)15:13<1307::AID-YEA455>3.0.CO;2-3 |doilabel=10.1002/(SICI)1097-0061(19990930)15:131307::AID-YEA4553.0.CO;2-3
*cite journal | author=Hattori M, Fujiyama A, Taylor TD, "et al." |title=The DNA sequence of human chromosome 21. |journal=Nature |volume=405 |issue= 6784 |pages= 311–9 |year= 2000 |pmid= 10830953 |doi= 10.1038/35012518
*cite journal | author=Wynn SL, Fisher RA, Pagel C, "et al." |title=Organization and conservation of the GART/SON/DONSON locus in mouse and human genomes. |journal=Genomics |volume=68 |issue= 1 |pages= 57–62 |year= 2001 |pmid= 10950926 |doi= 10.1006/geno.2000.6254
*cite journal | author=Sun CT, Lo WY, Wang IH, "et al." |title=Transcription repression of human hepatitis B virus genes by negative regulatory element-binding protein/SON. |journal=J. Biol. Chem. |volume=276 |issue= 26 |pages= 24059–67 |year= 2001 |pmid= 11306577 |doi= 10.1074/jbc.M101330200
*cite journal | author=Reymond A, Friedli M, Henrichsen CN, "et al." |title=From PREDs and open reading frames to cDNA isolation: revisiting the human chromosome 21 transcription map. |journal=Genomics |volume=78 |issue= 1-2 |pages= 46–54 |year= 2002 |pmid= 11707072 |doi= 10.1006/geno.2001.6640
*cite journal | author=Yi J, Kloeker S, Jensen CC, "et al." |title=Members of the Zyxin family of LIM proteins interact with members of the p130Cas family of signal transducers. |journal=J. Biol. Chem. |volume=277 |issue= 11 |pages= 9580–9 |year= 2002 |pmid= 11782456 |doi= 10.1074/jbc.M106922200
*cite journal | author=Strausberg RL, Feingold EA, Grouse LH, "et al." |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899
*cite journal | author=Casadei R, Strippoli P, D'Addabbo P, "et al." |title=mRNA 5' region sequence incompleteness: a potential source of systematic errors in translation initiation codon assignment in human mRNAs. |journal=Gene |volume=321 |issue= |pages= 185–93 |year= 2004 |pmid= 14637006 |doi=
*cite journal | author=Ota T, Suzuki Y, Nishikawa T, "et al." |title=Complete sequencing and characterization of 21,243 full-length human cDNAs. |journal=Nat. Genet. |volume=36 |issue= 1 |pages= 40–5 |year= 2004 |pmid= 14702039 |doi= 10.1038/ng1285
*cite journal | author=Hillman RT, Green RE, Brenner SE |title=An unappreciated role for RNA surveillance. |journal=Genome Biol. |volume=5 |issue= 2 |pages= R8 |year= 2005 |pmid= 14759258 |doi= 10.1186/gb-2004-5-2-r8
*cite journal | author=Colland F, Jacq X, Trouplin V, "et al." |title=Functional proteomics mapping of a human signaling pathway. |journal=Genome Res. |volume=14 |issue= 7 |pages= 1324–32 |year= 2004 |pmid= 15231748 |doi= 10.1101/gr.2334104

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