SOAT1

Sterol O-acyltransferase (acyl-Coenzyme A: cholesterol acyltransferase) 1, also known as SOAT1, is a human gene.cite web | title = Entrez Gene: SOAT1 sterol O-acyltransferase (acyl-Coenzyme A: cholesterol acyltransferase) 1| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=6646| accessdate = ]

PBB_Summary
section_title =
summary_text = Acyl-coenzyme A:cholesterol acyltransferase (ACACT; EC 2.3.1.26) is an intracellular protein located in the endoplasmic reticulum that forms cholesterol esters from cholesterol. Accumulation of cholesterol esters as cytoplasmic lipid droplets within macrophages and smooth muscle cells is a characteristic feature of the early stages of atherosclerotic plaques (Cadigan et al., 1988). [supplied by OMIM] cite web | title = Entrez Gene: SOAT1 sterol O-acyltransferase (acyl-Coenzyme A: cholesterol acyltransferase) 1| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=6646| accessdate = ]

References

Further reading

PBB_Further_reading
citations =
*cite journal | author=Chang TY, Chang CC, Lin S, "et al." |title=Roles of acyl-coenzyme A:cholesterol acyltransferase-1 and -2. |journal=Curr. Opin. Lipidol. |volume=12 |issue= 3 |pages= 289–96 |year= 2001 |pmid= 11353332 |doi=
*cite journal | author=Chang CC, Noll WW, Nutile-McMenemy N, "et al." |title=Localization of acyl coenzyme A:cholesterol acyltransferase gene to human chromosome 1q25. |journal=Somat. Cell Mol. Genet. |volume=20 |issue= 1 |pages= 71–4 |year= 1994 |pmid= 8197480 |doi=
*cite journal | author=Chang CC, Huh HY, Cadigan KM, Chang TY |title=Molecular cloning and functional expression of human acyl-coenzyme A:cholesterol acyltransferase cDNA in mutant Chinese hamster ovary cells. |journal=J. Biol. Chem. |volume=268 |issue= 28 |pages= 20747–55 |year= 1993 |pmid= 8407899 |doi=
*cite journal | author=Oelkers P, Behari A, Cromley D, "et al." |title=Characterization of two human genes encoding acyl coenzyme A:cholesterol acyltransferase-related enzymes. |journal=J. Biol. Chem. |volume=273 |issue= 41 |pages= 26765–71 |year= 1998 |pmid= 9756920 |doi=
*cite journal | author=Li BL, Li XL, Duan ZJ, "et al." |title=Human acyl-CoA:cholesterol acyltransferase-1 (ACAT-1) gene organization and evidence that the 4.3-kilobase ACAT-1 mRNA is produced from two different chromosomes. |journal=J. Biol. Chem. |volume=274 |issue= 16 |pages= 11060–71 |year= 1999 |pmid= 10196189 |doi=
*cite journal | author=Lin S, Cheng D, Liu MS, "et al." |title=Human acyl-CoA:cholesterol acyltransferase-1 in the endoplasmic reticulum contains seven transmembrane domains. |journal=J. Biol. Chem. |volume=274 |issue= 33 |pages= 23276–85 |year= 1999 |pmid= 10438503 |doi=
*cite journal | author=Sakashita N, Miyazaki A, Takeya M, "et al." |title=Localization of human acyl-coenzyme A: cholesterol acyltransferase-1 (ACAT-1) in macrophages and in various tissues. |journal=Am. J. Pathol. |volume=156 |issue= 1 |pages= 227–36 |year= 2000 |pmid= 10623671 |doi=
*cite journal | author=Guo Z, Cromley D, Billheimer JT, Sturley SL |title=Identification of potential substrate-binding sites in yeast and human acyl-CoA sterol acyltransferases by mutagenesis of conserved sequences. |journal=J. Lipid Res. |volume=42 |issue= 8 |pages= 1282–91 |year= 2001 |pmid= 11483630 |doi=
*cite journal | author=Strausberg RL, Feingold EA, Grouse LH, "et al." |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899
*cite journal | author=Zhang Y, Yu C, Liu J, "et al." |title=Cholesterol is superior to 7-ketocholesterol or 7 alpha-hydroxycholesterol as an allosteric activator for acyl-coenzyme A:cholesterol acyltransferase 1. |journal=J. Biol. Chem. |volume=278 |issue= 13 |pages= 11642–7 |year= 2003 |pmid= 12533546 |doi= 10.1074/jbc.M211559200
*cite journal | author=Wollmer MA, Streffer JR, Tsolaki M, "et al." |title=Genetic association of acyl-coenzyme A: cholesterol acyltransferase with cerebrospinal fluid cholesterol levels, brain amyloid load, and risk for Alzheimer's disease. |journal=Mol. Psychiatry |volume=8 |issue= 6 |pages= 635–8 |year= 2004 |pmid= 12851640 |doi= 10.1038/sj.mp.4001296
*cite journal | author=Smith JL, Rangaraj K, Simpson R, "et al." |title=Quantitative analysis of the expression of ACAT genes in human tissues by real-time PCR. |journal=J. Lipid Res. |volume=45 |issue= 4 |pages= 686–96 |year= 2004 |pmid= 14729857 |doi= 10.1194/jlr.M300365-JLR200
*cite journal | author=Hori M, Miyazaki A, Tamagawa H, "et al." |title=Up-regulation of acyl-coenzyme A:cholesterol acyltransferase-1 by transforming growth factor-beta1 during differentiation of human monocytes into macrophages. |journal=Biochem. Biophys. Res. Commun. |volume=320 |issue= 2 |pages= 501–5 |year= 2004 |pmid= 15219857 |doi= 10.1016/j.bbrc.2004.05.190
*cite journal | author=Yang L, Chen J, Chang CC, "et al." |title=A stable upstream stem-loop structure enhances selection of the first 5'-ORF-AUG as a main start codon for translation initiation of human ACAT1 mRNA. |journal=Acta Biochim. Biophys. Sin. (Shanghai) |volume=36 |issue= 4 |pages= 259–68 |year= 2004 |pmid= 15253151 |doi=
*cite journal | author=Liang JJ, Oelkers P, Guo C, "et al." |title=Overexpression of human diacylglycerol acyltransferase 1, acyl-coa:cholesterol acyltransferase 1, or acyl-CoA:cholesterol acyltransferase 2 stimulates secretion of apolipoprotein B-containing lipoproteins in McA-RH7777 cells. |journal=J. Biol. Chem. |volume=279 |issue= 43 |pages= 44938–44 |year= 2004 |pmid= 15308631 |doi= 10.1074/jbc.M408507200
*cite journal | author=Yang L, Lee O, Chen J, "et al." |title=Human acyl-coenzyme A:cholesterol acyltransferase 1 (acat1) sequences located in two different chromosomes (7 and 1) are required to produce a novel ACAT1 isoenzyme with additional sequence at the N terminus. |journal=J. Biol. Chem. |volume=279 |issue= 44 |pages= 46253–62 |year= 2004 |pmid= 15319423 |doi= 10.1074/jbc.M408155200
*cite journal | author=Yang L, Yang JB, Chen J, "et al." |title=Enhancement of human ACAT1 gene expression to promote the macrophage-derived foam cell formation by dexamethasone. |journal=Cell Res. |volume=14 |issue= 4 |pages= 315–23 |year= 2005 |pmid= 15353128 |doi= 10.1038/sj.cr.7290231
*cite journal | author=Gerhard DS, Wagner L, Feingold EA, "et al." |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121–7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504
*cite journal | author=Bertram L, Hsiao M, Mullin K, "et al." |title=ACAT1 is not associated with Alzheimer's disease in two independent family-based samples. |journal=Mol. Psychiatry |volume=10 |issue= 6 |pages= 522–4 |year= 2005 |pmid= 15768051 |doi= 10.1038/sj.mp.4001646

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