Nuclear receptor coactivator 6
Symbols NCOA6; AIB3; ASC2; KIAA0181; NRC; PRIP; RAP250; TRBP
External IDs OMIM605299 MGI1929915 HomoloGene40920 GeneCards: NCOA6 Gene
RNA expression pattern
PBB GE NCOA6 208979 at tn.png
More reference expression data
Species Human Mouse
Entrez 23054 56406
Ensembl ENSG00000198646 ENSMUSG00000038369
UniProt Q14686 Q3TAG3
RefSeq (mRNA) NM_001242539.1 NM_019825
RefSeq (protein) NP_001229468.1 NP_062799
Location (UCSC) Chr 20:
33.3 – 33.41 Mb
Chr 2:
155.22 – 155.3 Mb
PubMed search [1] [2]

Nuclear receptor coactivator 6 is a protein that in humans is encoded by the NCOA6 gene.[1][2][3]

The protein encoded by this gene is a transcriptional coactivator that can interact with nuclear hormone receptors to enhance their transcriptional activator functions. The encoded protein has been shown to be involved in the hormone-dependent coactivation of several receptors, including prostanoid, retinoid, vitamin D3, thyroid hormone, and steroid receptors. The encoded protein may also act as a general coactivator since it has been shown to interact with some basal transcription factors, histone acetyltransferases, and methyltransferases.[3]



NCOA6 has been shown to interact with Ku70,[4][5] RBBP5,[6] E2F1,[7] Retinoblastoma protein,[8] CREB-binding protein,[9][10] Activating transcription factor 2,[11] HSF1,[12] HBXIP,[13] TGS1,[14][15] TUBB,[6] TUBA4A,[6] Thyroid hormone receptor beta,[4][9][10][16] Retinoic acid receptor alpha,[4][9][10] Src,[6][9][10][17] Thyroid hormone receptor alpha,[9][17] DNA-PKcs,[4] Androgen receptor,[8] HIST2H3C,[6] MLL3,[6] Ku80,[4][5] Liver X receptor beta,[10] Estrogen receptor alpha,[9][16] Estrogen receptor beta,[10][16] EP300,[4] ASCL2[6] and Retinoid X receptor alpha.[9][10][13][16]

See also


  1. ^ Nagase T, Seki N, Ishikawa K, Tanaka A, Nomura N (Nov 1996). "Prediction of the coding sequences of unidentified human genes. V. The coding sequences of 40 new genes (KIAA0161-KIAA0200) deduced by analysis of cDNA clones from human cell line KG-1". DNA Res 3 (1): 17–24. doi:10.1093/dnares/3.1.17. PMID 8724849. 
  2. ^ Estey A, Kemp M, Allison S, Lamb C (Jan 1994). "Evaluation of a patient information booklet". J Nurs Staff Dev 9 (6): 278–82. PMID 8263591. 
  3. ^ a b "Entrez Gene: NCOA6 nuclear receptor coactivator 6". 
  4. ^ a b c d e f Ko, L; Cardona G R, Chin W W (May. 2000). "Thyroid hormone receptor-binding protein, an LXXLL motif-containing protein, functions as a general coactivator". Proc. Natl. Acad. Sci. U.S.A. (UNITED STATES) 97 (11): 6212–7. doi:10.1073/pnas.97.11.6212. ISSN 0027-8424. PMC 18584. PMID 10823961. 
  5. ^ a b Ko, Lan; Chin William W (Mar. 2003). "Nuclear receptor coactivator thyroid hormone receptor-binding protein (TRBP) interacts with and stimulates its associated DNA-dependent protein kinase". J. Biol. Chem. (United States) 278 (13): 11471–9. doi:10.1074/jbc.M209723200. ISSN 0021-9258. PMID 12519782. 
  6. ^ a b c d e f g Goo, Young-Hwa; Sohn Young Chang, Kim Dae-Hwan, Kim Seung-Whan, Kang Min-Jung, Jung Dong-Ju, Kwak Eunyee, Barlev Nickolai A, Berger Shelley L, Chow Vincent T, Roeder Robert G, Azorsa David O, Meltzer Paul S, Suh Pan-Gil, Song Eun Joo, Lee Kong-Joo, Lee Young Chul, Lee Jae Woon (Jan. 2003). "Activating signal cointegrator 2 belongs to a novel steady-state complex that contains a subset of trithorax group proteins". Mol. Cell. Biol. (United States) 23 (1): 140–9. doi:10.1128/MCB.23.1.140-149.2003. ISSN 0270-7306. PMC 140670. PMID 12482968. 
  7. ^ Kong, Hee Jeong; Yu Hyun Jung, Hong SunHwa, Park Min Jung, Choi Young Hyun, An Won Gun, Lee Jae Woon, Cheong JaeHun (Nov. 2003). "Interaction and functional cooperation of the cancer-amplified transcriptional coactivator activating signal cointegrator-2 and E2F-1 in cell proliferation". Mol. Cancer Res. (United States) 1 (13): 948–58. ISSN 1541-7786. PMID 14638867. 
  8. ^ a b Goo, Young-Hwa; Na Soon-Young, Zhang Hao, Xu Jianming, Hong SunHwa, Cheong JaeHun, Lee Soo-Kyung, Lee Jae Woon (Feb. 2004). "Interactions between activating signal cointegrator-2 and the tumor suppressor retinoblastoma in androgen receptor transactivation". J. Biol. Chem. (United States) 279 (8): 7131–5. doi:10.1074/jbc.M312563200. ISSN 0021-9258. PMID 14645241. 
  9. ^ a b c d e f g Lee, S K; Anzick S L, Choi J E, Bubendorf L, Guan X Y, Jung Y K, Kallioniemi O P, Kononen J, Trent J M, Azorsa D, Jhun B H, Cheong J H, Lee Y C, Meltzer P S, Lee J W (Nov. 1999). "A nuclear factor, ASC-2, as a cancer-amplified transcriptional coactivator essential for ligand-dependent transactivation by nuclear receptors in vivo". J. Biol. Chem. (UNITED STATES) 274 (48): 34283–93. doi:10.1074/jbc.274.48.34283. ISSN 0021-9258. PMID 10567404. 
  10. ^ a b c d e f g Lee, S K; Jung S Y, Kim Y S, Na S Y, Lee Y C, Lee J W (Feb. 2001). "Two distinct nuclear receptor-interaction domains and CREB-binding protein-dependent transactivation function of activating signal cointegrator-2". Mol. Endocrinol. (United States) 15 (2): 241–54. doi:10.1210/me.15.2.241. ISSN 0888-8809. PMID 11158331. 
  11. ^ Hong, SunHwa; Choi Hyun Mi, Park Min Jung, Kim Young Hee, Choi Yoon Ha, Kim Hyung Hoi, Choi Young Hyun, Cheong JaeHun (Apr. 2004). "Activation and interaction of ATF2 with the coactivator ASC-2 are responsive for granulocytic differentiation by retinoic acid". J. Biol. Chem. (United States) 279 (17): 16996–7003. doi:10.1074/jbc.M311752200. ISSN 0021-9258. PMID 14734562. 
  12. ^ Hong, SunHwa; Kim Sun Hee, Heo Mi Ae, Choi Yoon Ha, Park Min Jung, Yoo Mi Ae, Kim Han Do, Kang Ho Sung, Cheong JaeHun (Feb. 2004). "Coactivator ASC-2 mediates heat shock factor 1-mediated transactivation dependent on heat shock". FEBS Lett. (Netherlands) 559 (1–3): 165–70. doi:10.1016/S0014-5793(04)00028-6. ISSN 0014-5793. PMID 14960326. 
  13. ^ a b Kong, Hee Jeong; Park Min Jung, Hong SunHwa, Yu Hyun Jung, Lee Young Chul, Choi Young Hyun, Cheong JaeHun (Nov. 2003). "Hepatitis B virus X protein regulates transactivation activity and protein stability of the cancer-amplified transcription coactivator ASC-2". Hepatology (United States) 38 (5): 1258–66. doi:10.1053/jhep.2003.50451. ISSN 0270-9139. PMID 14578865. 
  14. ^ Misra, Parimal; Qi Chao, Yu Songtao, Shah Sejal H, Cao Wen-Qing, Rao M Sambasiva, Thimmapaya Bayar, Zhu Yijun, Reddy Janardan K (May. 2002). "Interaction of PIMT with transcriptional coactivators CBP, p300, and PBP differential role in transcriptional regulation". J. Biol. Chem. (United States) 277 (22): 20011–9. doi:10.1074/jbc.M201739200. ISSN 0021-9258. PMID 11912212. 
  15. ^ Zhu, Y; Qi C, Cao W Q, Yeldandi A V, Rao M S, Reddy J K (Aug. 2001). "Cloning and characterization of PIMT, a protein with a methyltransferase domain, which interacts with and enhances nuclear receptor coactivator PRIP function". Proc. Natl. Acad. Sci. U.S.A. (United States) 98 (18): 10380–5. doi:10.1073/pnas.181347498. ISSN 0027-8424. PMC 56969. PMID 11517327. 
  16. ^ a b c d Ko, Lan; Cardona Guemalli R, Iwasaki Toshiharu, Bramlett Kelli S, Burris Thomas P, Chin William W (Jan. 2002). "Ser-884 adjacent to the LXXLL motif of coactivator TRBP defines selectivity for ERs and TRs". Mol. Endocrinol. (United States) 16 (1): 128–40. doi:10.1210/me.16.1.128. ISSN 0888-8809. PMID 11773444. 
  17. ^ a b Lee, S K; Na S Y, Jung S Y, Choi J E, Jhun B H, Cheong J, Meltzer P S, Lee Y C, Lee J W (Jun. 2000). "Activating protein-1, nuclear factor-kappaB, and serum response factor as novel target molecules of the cancer-amplified transcription coactivator ASC-2". Mol. Endocrinol. (UNITED STATES) 14 (6): 915–25. doi:10.1210/me.14.6.915. ISSN 0888-8809. PMID 10847592. 

External links

Further reading

This article incorporates text from the United States National Library of Medicine, which is in the public domain.

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