FGF10 (gene)

FGF10 (gene)

Fibroblast growth factor 10, also known as FGF10, is a human gene.cite web | title = Entrez Gene: FGF10 fibroblast growth factor 10| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=2255| accessdate = ]

section_title =
summary_text = The protein encoded by this gene is a member of the fibroblast growth factor (FGF) family. FGF family members possess broad mitogenic and cell survival activities, and are involved in a variety of biological processes, including embryonic development, cell growth, morphogenesis, tissue repair, tumor growth and invasion. This protein exhibits mitogenic activity for keratinizing epidermal cells, but essentially no activity for fibroblasts, which is similar to the biological activity of FGF7. Studies of the mouse homolog of suggested that this gene is required for embryonic epidermal morphogenesis including brain development, lung morphogenesis, and initiation of lim bud formation. This gene is also implicated to be a primary factor in the process of wound healing.cite web | title = Entrez Gene: FGF10 fibroblast growth factor 10| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=2255| accessdate = ]


Further reading

citations =
*cite journal | author=Emoto H, Tagashira S, Mattei MG, "et al." |title=Structure and expression of human fibroblast growth factor-10. |journal=J. Biol. Chem. |volume=272 |issue= 37 |pages= 23191–4 |year= 1997 |pmid= 9287324 |doi=
*cite journal | author=Igarashi M, Finch PW, Aaronson SA |title=Characterization of recombinant human fibroblast growth factor (FGF)-10 reveals functional similarities with keratinocyte growth factor (FGF-7). |journal=J. Biol. Chem. |volume=273 |issue= 21 |pages= 13230–5 |year= 1998 |pmid= 9582367 |doi=
*cite journal | author=Sekine K, Ohuchi H, Fujiwara M, "et al." |title=Fgf10 is essential for limb and lung formation. |journal=Nat. Genet. |volume=21 |issue= 1 |pages= 138–41 |year= 1999 |pmid= 9916808 |doi= 10.1038/5096
*cite journal | author=Jimenez PA, Rampy MA |title=Keratinocyte growth factor-2 accelerates wound healing in incisional wounds. |journal=J. Surg. Res. |volume=81 |issue= 2 |pages= 238–42 |year= 1999 |pmid= 9927546 |doi= 10.1006/jsre.1998.5501
*cite journal | author=Ropiquet F, Giri D, Kwabi-Addo B, "et al." |title=FGF-10 is expressed at low levels in the human prostate. |journal=Prostate |volume=44 |issue= 4 |pages= 334–8 |year= 2000 |pmid= 10951499 |doi=
*cite journal | author=Marchese C, Felici A, Visco V, "et al." |title=Fibroblast growth factor 10 induces proliferation and differentiation of human primary cultured keratinocytes. |journal=J. Invest. Dermatol. |volume=116 |issue= 4 |pages= 623–8 |year= 2001 |pmid= 11286634 |doi= 10.1046/j.0022-202x.2001.01280.x
*cite journal | author=Bagai S, Rubio E, Cheng JF, "et al." |title=Fibroblast growth factor-10 is a mitogen for urothelial cells. |journal=J. Biol. Chem. |volume=277 |issue= 26 |pages= 23828–37 |year= 2002 |pmid= 11923311 |doi= 10.1074/jbc.M201658200
*cite journal | author=Strausberg RL, Feingold EA, Grouse LH, "et al." |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899
*cite journal | author=Yeh BK, Igarashi M, Eliseenkova AV, "et al." |title=Structural basis by which alternative splicing confers specificity in fibroblast growth factor receptors. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=100 |issue= 5 |pages= 2266–71 |year= 2003 |pmid= 12591959 |doi= 10.1073/pnas.0436500100
*cite journal | author=Upadhyay D, Lecuona E, Comellas A, "et al." |title=Fibroblast growth factor-10 upregulates Na,K-ATPase via the MAPK pathway. |journal=FEBS Lett. |volume=545 |issue= 2-3 |pages= 173–6 |year= 2003 |pmid= 12804770 |doi=
*cite journal | author=Izvolsky KI, Zhong L, Wei L, "et al." |title=Heparan sulfates expressed in the distal lung are required for Fgf10 binding to the epithelium and for airway branching. |journal=Am. J. Physiol. Lung Cell Mol. Physiol. |volume=285 |issue= 4 |pages= L838–46 |year= 2003 |pmid= 12818887 |doi= 10.1152/ajplung.00081.2003
*cite journal | author=Tomlinson DC, Grindley JC, Thomson AA |title=Regulation of Fgf10 gene expression in the prostate: identification of transforming growth factor-beta1 and promoter elements. |journal=Endocrinology |volume=145 |issue= 4 |pages= 1988–95 |year= 2004 |pmid= 14726452 |doi= 10.1210/en.2003-0842
*cite journal | author=Upadhyay D, Bundesmann M, Panduri V, "et al." |title=Fibroblast growth factor-10 attenuates H2O2-induced alveolar epithelial cell DNA da

*cite journal | author=Theodorou V, Boer M, Weigelt B, "et al." |title=Fgf10 is an oncogene activated by MMTV insertional mutagenesis in mouse mammary tumors and overexpressed in a subset of human breast carcinomas. |journal=Oncogene |volume=23 |issue= 36 |pages= 6047–55 |year= 2005 |pmid= 15208658 |doi= 10.1038/sj.onc.1207816
*cite journal | author=Gerhard DS, Wagner L, Feingold EA, "et al." |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121–7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504
*cite journal | author=Ibrahimi OA, Yeh BK, Eliseenkova AV, "et al." |title=Analysis of mutations in fibroblast growth factor (FGF) and a pathogenic mutation in FGF receptor (FGFR) provides direct evidence for the symmetric two-end model for FGFR dimerization. |journal=Mol. Cell. Biol. |volume=25 |issue= 2 |pages= 671–84 |year= 2005 |pmid= 15632068 |doi= 10.1128/MCB.25.2.671-684.2005
*cite journal | author=Entesarian M, Matsson H, Klar J, "et al." |title=Mutations in the gene encoding fibroblast growth factor 10 are associated with aplasia of lacrimal and salivary glands. |journal=Nat. Genet. |volume=37 |issue= 2 |pages= 125–7 |year= 2005 |pmid= 15654336 |doi= 10.1038/ng1507
*cite journal | author=Kovacs D, Falchi M, Cardinali G, "et al." |title=Immunohistochemical analysis of keratinocyte growth factor and fibroblast growth factor 10 expression in psoriasis. |journal=Exp. Dermatol. |volume=14 |issue= 2 |pages= 130–7 |year= 2005 |pmid= 15679583 |doi= 10.1111/j.0906-6705.2005.00261.x
*cite journal | author=Ye F, Duvillié B, Scharfmann R |title=Fibroblast growth factors 7 and 10 are expressed in the human embryonic pancreatic mesenchyme and promote the proliferation of embryonic pancreatic epithelial cells. |journal=Diabetologia |volume=48 |issue= 2 |pages= 277–81 |year= 2005 |pmid= 15690149 |doi= 10.1007/s00125-004-1638-6
*cite journal | author=Beer HD, Bittner M, Niklaus G, "et al." |title=The fibroblast growth factor binding protein is a novel interaction partner of FGF-7, FGF-10 and FGF-22 and regulates FGF activity: implications for epithelial repair. |journal=Oncogene |volume=24 |issue= 34 |pages= 5269–77 |year= 2005 |pmid= 15806171 |doi= 10.1038/sj.onc.1208560

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