Fragile X mental retardation, autosomal homolog 1, also known as FXR1, is a human gene.cite web | title = Entrez Gene: FXR1 fragile X mental retardation, autosomal homolog 1| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=8087| accessdate = ]

section_title =
summary_text = The protein encoded by this gene is an RNA binding protein that interacts with the functionally-similar proteins FMR1 and FXR2. These proteins shuttle between the nucleus and cytoplasm and associate with polyribosomes, predominantly with the 60S ribosomal subunit. Three transcript variants encoding different isoforms have been found for this gene.cite web | title = Entrez Gene: FXR1 fragile X mental retardation, autosomal homolog 1| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=8087| accessdate = ]


Further reading

citations =
*cite journal | author=Zhang Y, O'Connor JP, Siomi MC, "et al." |title=The fragile X mental retardation syndrome protein interacts with novel homologs FXR1 and FXR2. |journal=EMBO J. |volume=14 |issue= 21 |pages= 5358–66 |year= 1996 |pmid= 7489725 |doi=
*cite journal | author=Siomi MC, Siomi H, Sauer WH, "et al." |title=FXR1, an autosomal homolog of the fragile X mental retardation gene. |journal=EMBO J. |volume=14 |issue= 11 |pages= 2401–8 |year= 1995 |pmid= 7781595 |doi=
*cite journal | author=Maruyama K, Sugano S |title=Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides. |journal=Gene |volume=138 |issue= 1-2 |pages= 171–4 |year= 1994 |pmid= 8125298 |doi=
*cite journal | author=Coy JF, Sedlacek Z, Bächner D, "et al." |title=Highly conserved 3' UTR and expression pattern of FXR1 points to a divergent gene regulation of FXR1 and FMR1. |journal=Hum. Mol. Genet. |volume=4 |issue= 12 |pages= 2209–18 |year= 1996 |pmid= 8634689 |doi=
*cite journal | author=Siomi MC, Zhang Y, Siomi H, Dreyfuss G |title=Specific sequences in the fragile X syndrome protein FMR1 and the FXR proteins mediate their binding to 60S ribosomal subunits and the interactions among them. |journal=Mol. Cell. Biol. |volume=16 |issue= 7 |pages= 3825–32 |year= 1996 |pmid= 8668200 |doi=
*cite journal | author=Tamanini F, Willemsen R, van Unen L, "et al." |title=Differential expression of FMR1, FXR1 and FXR2 proteins in human brain and testis. |journal=Hum. Mol. Genet. |volume=6 |issue= 8 |pages= 1315–22 |year= 1997 |pmid= 9259278 |doi=
*cite journal | author=Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, "et al." |title=Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library. |journal=Gene |volume=200 |issue= 1-2 |pages= 149–56 |year= 1997 |pmid= 9373149 |doi=
*cite journal | author=Bolívar J, Guelman S, Iglesias C, "et al." |title=The fragile-X-related gene FXR1 is a human autoantigen processed during apoptosis. |journal=J. Biol. Chem. |volume=273 |issue= 27 |pages= 17122–7 |year= 1998 |pmid= 9642279 |doi=
*cite journal | author=Khandjian EW, Bardoni B, Corbin F, "et al." |title=Novel isoforms of the fragile X related protein FXR1P are expressed during myogenesis. |journal=Hum. Mol. Genet. |volume=7 |issue= 13 |pages= 2121–8 |year= 1999 |pmid= 9817930 |doi=
*cite journal | author=Tamanini F, Bontekoe C, Bakker CE, "et al." |title=Different targets for the fragile X-related proteins revealed by their distinct nuclear localizations. |journal=Hum. Mol. Genet. |volume=8 |issue= 5 |pages= 863–9 |year= 1999 |pmid= 10196376 |doi=
*cite journal | author=Tamanini F, Van Unen L, Bakker C, "et al." |title=Oligomerization properties of fragile-X mental-retardation protein (FMRP) and the fragile-X-related proteins FXR1P and FXR2P. |journal=Biochem. J. |volume=343 Pt 3 |issue= |pages= 517–23 |year= 2000 |pmid= 10527928 |doi=
*cite journal | author=Bardoni B, Schenck A, Mandel JL |title=A novel RNA-binding nuclear protein that interacts with the fragile X mental retardation (FMR1) protein. |journal=Hum. Mol. Genet. |volume=8 |issue= 13 |pages= 2557–66 |year= 2000 |pmid= 10556305 |doi=
*cite journal | author=Ceman S, Brown V, Warren ST |title=Isolation of an FMRP-associated messenger ribonucleoprotein particle and identification of nucleolin and the fragile X-related proteins as components of the complex. |journal=Mol. Cell. Biol. |volume=19 |issue= 12 |pages= 7925–32 |year= 2000 |pmid= 10567518 |doi=
*cite journal | author=Tamanini F, Kirkpatrick LL, Schonkeren J, "et al." |title=The fragile X-related proteins FXR1P and FXR2P contain a functional nucleolar-targeting signal equivalent to the HIV-1 regulatory proteins. |journal=Hum. Mol. Genet. |volume=9 |issue= 10 |pages= 1487–93 |year= 2000 |pmid= 10888599 |doi=
*cite journal | author=Hartley JL, Temple GF, Brasch MA |title=DNA cloning using in vitro site-specific recombination. |journal=Genome Res. |volume=10 |issue= 11 |pages= 1788–95 |year= 2001 |pmid= 11076863 |doi=
*cite journal | author=Schenck A, Bardoni B, Moro A, "et al." |title=A highly conserved protein family interacting with the fragile X mental retardation protein (FMRP) and displaying selective interactions with FMRP-related proteins FXR1P and FXR2P. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=98 |issue= 15 |pages= 8844–9 |year= 2001 |pmid= 11438699 |doi= 10.1073/pnas.151231598
*cite journal | author=Kirkpatrick LL, McIlwain KA, Nelson DL |title=Comparative genomic sequence analysis of the FXR gene family: FMR1, FXR1, and FXR2. |journal=Genomics |volume=78 |issue= 3 |pages= 169–77 |year= 2002 |pmid= 11735223 |doi= 10.1006/geno.2001.6667
*cite journal | author=Strausberg RL, Feingold EA, Grouse LH, "et al." |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899
*cite journal | author=Imabayashi H, Mori T, Gojo S, "et al." |title=Redifferentiation of dedifferentiated chondrocytes and chondrogenesis of human bone marrow stromal cells via chondrosphere formation with expression profiling by large-scale cDNA analysis. |journal=Exp. Cell Res. |volume=288 |issue= 1 |pages= 35–50 |year= 2003 |pmid= 12878157 |doi=
*cite journal | author=Gerhard DS, Wagner L, Feingold EA, "et al." |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121–7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504

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  • FXR2 — Fragile X mental retardation, autosomal homolog 2, also known as FXR2, is a human gene.cite web | title = Entrez Gene: FXR2 fragile X mental retardation, autosomal homolog 2| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene… …   Wikipedia