CDC5L

CDC5 cell division cycle 5-like (S. pombe), also known as CDC5L, is a human gene.cite web | title = Entrez Gene: CDC5L CDC5 cell division cycle 5-like (S. pombe)| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=988| accessdate = ]

PBB_Summary
section_title =
summary_text = The protein encoded by this gene shares a significant similarity with Schizosaccharomyces pombe cdc5 gene product, which is a cell cycle regulator important for G2/M transition. This protein has been demonstrated to act as a positive regulator of cell cycle G2/M progression. It was also found to be an essential component of a non-snRNA spliceosome, which contains at least five additional protein factors and is required for the second catalytic step of pre-mRNA splicing.cite web | title = Entrez Gene: CDC5L CDC5 cell division cycle 5-like (S. pombe)| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=988| accessdate = ]

References

Further reading

PBB_Further_reading
citations =
*cite journal | author=Nakajima D, Okazaki N, Yamakawa H, "et al." |title=Construction of expression-ready cDNA clones for KIAA genes: manual curation of 330 KIAA cDNA clones. |journal=DNA Res. |volume=9 |issue= 3 |pages= 99–106 |year= 2003 |pmid= 12168954 |doi=
*cite journal | author=Heaney JP, Jacobson A |title=Simplified control of upper abdominal hemorrhage from the vena cava. |journal=Surgery |volume=78 |issue= 2 |pages= 138–41 |year= 1975 |pmid= 1154257 |doi=
*cite journal | author=Hirayama T, Shinozaki K |title=A cdc5+ homolog of a higher plant, Arabidopsis thaliana. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=93 |issue= 23 |pages= 13371–6 |year= 1996 |pmid= 8917598 |doi=
*cite journal | author=Bernstein HS, Coughlin SR |title=Pombe Cdc5-related protein. A putative human transcription factor implicated in mitogen-activated signaling. |journal=J. Biol. Chem. |volume=272 |issue= 9 |pages= 5833–7 |year= 1997 |pmid= 9038199 |doi=
*cite journal | author=Ishikawa K, Nagase T, Nakajima D, "et al." |title=Prediction of the coding sequences of unidentified human genes. VIII. 78 new cDNA clones from brain which code for large proteins in vitro. |journal=DNA Res. |volume=4 |issue= 5 |pages= 307–13 |year= 1998 |pmid= 9455477 |doi=
*cite journal | author=Bernstein HS, Coughlin SR |title=A mammalian homolog of fission yeast Cdc5 regulates G2 progression and mitotic entry. |journal=J. Biol. Chem. |volume=273 |issue= 8 |pages= 4666–71 |year= 1998 |pmid= 9468527 |doi=
*cite journal | author=Groenen PM, Vanderlinden G, Devriendt K, "et al." |title=Rearrangement of the human CDC5L gene by a t(6;19)(p21;q13.1) in a patient with multicystic renal dysplasia. |journal=Genomics |volume=49 |issue= 2 |pages= 218–29 |year= 1998 |pmid= 9598309 |doi= 10.1006/geno.1998.5254
*cite journal | author=Ohi R, Feoktistova A, McCann S, "et al." |title=Myb-related Schizosaccharomyces pombe cdc5p is structurally and functionally conserved in eukaryotes. |journal=Mol. Cell. Biol. |volume=18 |issue= 7 |pages= 4097–108 |year= 1998 |pmid= 9632794 |doi=
*cite journal | author=Neubauer G, King A, Rappsilber J, "et al." |title=Mass spectrometry and EST-database searching allows characterization of the multi-protein spliceosome complex. |journal=Nat. Genet. |volume=20 |issue= 1 |pages= 46–50 |year= 1998 |pmid= 9731529 |doi= 10.1038/1700
*cite journal | author=Burns CG, Ohi R, Krainer AR, Gould KL |title=Evidence that Myb-related CDC5 proteins are required for pre-mRNA splicing. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=96 |issue= 24 |pages= 13789–94 |year= 2000 |pmid= 10570151 |doi=
*cite journal | author=Boudrez A, Beullens M, Groenen P, "et al." |title=NIPP1-mediated interaction of protein phosphatase-1 with CDC5L, a regulator of pre-mRNA splicing and mitotic entry. |journal=J. Biol. Chem. |volume=275 |issue= 33 |pages= 25411–7 |year= 2000 |pmid= 10827081 |doi= 10.1074/jbc.M001676200
*cite journal | author=Lei XH, Shen X, Xu XQ, Bernstein HS |title=Human Cdc5, a regulator of mitotic entry, can act as a site-specific DNA binding protein. |journal=J. Cell. Sci. |volume=113 Pt 24 |issue= |pages= 4523–31 |year= 2001 |pmid= 11082045 |doi=
*cite journal | author=Ajuh P, Kuster B, Panov K, "et al." |title=Functional analysis of the human CDC5L complex and identification of its components by mass spectrometry. |journal=EMBO J. |volume=19 |issue= 23 |pages= 6569–81 |year= 2001 |pmid= 11101529 |doi= 10.1093/emboj/19.23.6569
*cite journal | author=Harrington JJ, Sherf B, Rundlett S, "et al." |title=Creation of genome-wide protein expression libraries using random activation of gene expression. |journal=Nat. Biotechnol. |volume=19 |issue= 5 |pages= 440–5 |year= 2001 |pmid= 11329013 |doi= 10.1038/88107
*cite journal | author=Ajuh P, Sleeman J, Chusainow J, Lamond AI |title=A direct interaction between the carboxyl-terminal region of CDC5L and the WD40 domain of PLRG1 is essential for pre-mRNA splicing. |journal=J. Biol. Chem. |volume=276 |issue= 45 |pages= 42370–81 |year= 2001 |pmid= 11544257 |doi= 10.1074/jbc.M105453200
*cite journal | author=Jurica MS, Licklider LJ, Gygi SR, "et al." |title=Purification and characterization of native spliceosomes suitable for three-dimensional structural analysis. |journal=RNA |volume=8 |issue= 4 |pages= 426–39 |year= 2002 |pmid= 11991638 |doi=
*cite journal | author=Strausberg RL, Feingold EA, Grouse LH, "et al." |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899
*cite journal | author=Leonard D, Ajuh P, Lamond AI, Legerski RJ |title=hLodestar/HuF2 interacts with CDC5L and is involved in pre-mRNA splicing. |journal=Biochem. Biophys. Res. Commun. |volume=308 |issue= 4 |pages= 793–801 |year= 2003 |pmid= 12927788 |doi=
*cite journal | author=Liu L, Gräub R, Hlaing M, "et al." |title=Distinct domains of human CDC5 direct its nuclear import and association with the spliceosome. |journal=Cell Biochem. Biophys. |volume=39 |issue= 2 |pages= 119–32 |year= 2004 |pmid= 14515018 |doi=

PBB_Controls
update_page = yes
require_manual_inspection = no
update_protein_box = yes
update_summary = yes
update_citations = yes