UGT1A6

UDP glucuronosyltransferase 1 family, polypeptide A6, also known as UGT1A6, is a human gene.cite web | title = Entrez Gene: UGT1A6 UDP glucuronosyltransferase 1 family, polypeptide A6| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=54578| accessdate = ]

PBB_Summary
section_title =
summary_text = This gene encodes a UDP-glucuronosyltransferase, an enzyme of the glucuronidation pathway that transforms small lipophilic molecules, such as steroids, bilirubin, hormones, and drugs, into water-soluble, excretable metabolites. This gene is part of a complex locus that encodes several UDP-glucuronosyltransferases. The locus includes thirteen unique alternate first exons followed by four common exons. Four of the alternate first exons are considered pseudogenes. Each of the remaining nine 5' exons may be spliced to the four common exons, resulting in nine proteins with different N-termini and identical C-termini. Each first exon encodes the substrate binding site, and is regulated by its own promoter. The enzyme encoded by this gene is active on phenolic and planar compounds. Alternative splicing in the unique 5' end of this gene results in two transcript variants.cite web | title = Entrez Gene: UGT1A6 UDP glucuronosyltransferase 1 family, polypeptide A6| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=54578| accessdate = ]

References

Further reading

PBB_Further_reading
citations =
*cite journal | author=Mackenzie PI, Owens IS, Burchell B, "et al." |title=The UDP glycosyltransferase gene superfamily: recommended nomenclature update based on evolutionary divergence. |journal=Pharmacogenetics |volume=7 |issue= 4 |pages= 255–69 |year= 1997 |pmid= 9295054 |doi=
*cite journal | author=Tukey RH, Strassburg CP |title=Human UDP-glucuronosyltransferases: metabolism, expression, and disease. |journal=Annu. Rev. Pharmacol. Toxicol. |volume=40 |issue= |pages= 581–616 |year= 2000 |pmid= 10836148 |doi= 10.1146/annurev.pharmtox.40.1.581
*cite journal | author=King CD, Rios GR, Green MD, Tephly TR |title=UDP-glucuronosyltransferases. |journal=Curr. Drug Metab. |volume=1 |issue= 2 |pages= 143–61 |year= 2001 |pmid= 11465080 |doi=
*cite journal | author=Bock KW, Köhle C |title=UDP-glucuronosyltransferase 1A6: structural, functional, and regulatory aspects. |journal=Meth. Enzymol. |volume=400 |issue= |pages= 57–75 |year= 2006 |pmid= 16399343 |doi= 10.1016/S0076-6879(05)00004-2
*cite journal | author=Ritter JK, Chen F, Sheen YY, "et al." |title=A novel complex locus UGT1 encodes human bilirubin, phenol, and other UDP-glucuronosyltransferase isozymes with identical carboxyl termini. |journal=J. Biol. Chem. |volume=267 |issue= 5 |pages= 3257–61 |year= 1992 |pmid= 1339448 |doi=
*cite journal | author=Bosma PJ, Chowdhury JR, Huang TJ, "et al." |title=Mechanisms of inherited deficiencies of multiple UDP-glucuronosyltransferase isoforms in two patients with Crigler-Najjar syndrome, type I. |journal=FASEB J. |volume=6 |issue= 10 |pages= 2859–63 |year= 1992 |pmid= 1634050 |doi=
*cite journal | author=Ritter JK, Crawford JM, Owens IS |title=Cloning of two human liver bilirubin UDP-glucuronosyltransferase cDNAs with expression in COS-1 cells. |journal=J. Biol. Chem. |volume=266 |issue= 2 |pages= 1043–7 |year= 1991 |pmid= 1898728 |doi=
*cite journal | author=Harding D, Jeremiah SJ, Povey S, Burchell B |title=Chromosomal mapping of a human phenol UDP-glucuronosyltransferase, GNT1. |journal=Ann. Hum. Genet. |volume=54 |issue= Pt 1 |pages= 17–21 |year= 1990 |pmid= 2108603 |doi=
*cite journal | author=Harding D, Fournel-Gigleux S, Jackson MR, Burchell B |title=Cloning and substrate specificity of a human phenol UDP-glucuronosyltransferase expressed in COS-7 cells. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=85 |issue= 22 |pages= 8381–5 |year= 1988 |pmid= 3141926 |doi=
*cite journal | author=Moghrabi N, Clarke DJ, Boxer M, Burchell B |title=Identification of an A-to-G missense mutation in exon 2 of the UGT1 gene complex that causes Crigler-Najjar syndrome type 2. |journal=Genomics |volume=18 |issue= 1 |pages= 171–3 |year= 1994 |pmid= 8276413 |doi= 10.1006/geno.1993.1451
*cite journal | author=Aono S, Yamada Y, Keino H, "et al." |title=Identification of defect in the genes for bilirubin UDP-glucuronosyl-transferase in a patient with Crigler-Najjar syndrome type II. |journal=Biochem. Biophys. Res. Commun. |volume=197 |issue= 3 |pages= 1239–44 |year= 1994 |pmid= 8280139 |doi= 10.1006/bbrc.1993.2610
*cite journal | author=Killard AJ, O'Kennedy R, Bogan DP |title=Analysis of the glucuronidation of 7-hydroxycoumarin by HPLC. |journal=Journal of pharmaceutical and biomedical analysis |volume=14 |issue= 11 |pages= 1585–90 |year= 1997 |pmid= 8877866 |doi=
*cite journal | author=Bonaldo MF, Lennon G, Soares MB |title=Normalization and subtraction: two approaches to facilitate gene discovery. |journal=Genome Res. |volume=6 |issue= 9 |pages= 791–806 |year= 1997 |pmid= 8889548 |doi=
*cite journal | author=Ciotti M, Marrone A, Potter C, Owens IS |title=Genetic polymorphism in the human UGT1A6 (planar phenol) UDP-glucuronosyltransferase: pharmacological implications. |journal=Pharmacogenetics |volume=7 |issue= 6 |pages= 485–95 |year= 1998 |pmid= 9429234 |doi=
*cite journal | author=Münzel PA, Lehmköster T, Brück M, "et al." |title=Aryl hydrocarbon receptor-inducible or constitutive expression of human UDP glucuronosyltransferase UGT1A6. |journal=Arch. Biochem. Biophys. |volume=350 |issue= 1 |pages= 72–8 |year= 1998 |pmid= 9466822 |doi= 10.1006/abbi.1997.0485
*cite journal | author=Duffy CF, O'Kennedy R |title=Determination of 7-hydroxycoumarin and its glucuronide and sulphate conjugates in liver slice incubates by capillary zone electrophoresis. |journal=Journal of pharmaceutical and biomedical analysis |volume=17 |issue= 8 |pages= 1279–84 |year= 1999 |pmid= 9800648 |doi=
*cite journal | author=Gong QH, Cho JW, Huang T, "et al." |title=Thirteen UDPglucuronosyltransferase genes are encoded at the human UGT1 gene complex locus. |journal=Pharmacogenetics |volume=11 |issue= 4 |pages= 357–68 |year= 2001 |pmid= 11434514 |doi=

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