BAIAP2

BAI1-associated protein 2, also known as BAIAP2, is a human gene.cite web | title = Entrez Gene: BAIAP2 BAI1-associated protein 2| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=10458| accessdate = ]

PBB_Summary
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summary_text = The protein encoded by this gene has been identified as a brain-specific angiogenesis inhibitor (BAI1)-binding protein. This interaction at the cytoplasmic membrane is crucial to the function of this protein, which may be involved in neuronal growth-cone guidance. This protein functions as an insulin receptor tyrosine kinase substrate and suggests a role for insulin in the central nervous system. This protein has also been identified as interacting with the dentatorubral-pallidoluysian atrophy gene, which is associated with an autosomal dominant neurodegenerative disease. It also associates with a downstream effector of Rho small G proteins, which is associated with the formation of stress fibers and cytokinesis. Alternative splicing of the 3'-end of this gene results in three products of undetermined function.cite web | title = Entrez Gene: BAIAP2 BAI1-associated protein 2| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=10458| accessdate = ]

References

Further reading

PBB_Further_reading
citations =
*cite journal | author=Maruyama K, Sugano S |title=Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides. |journal=Gene |volume=138 |issue= 1-2 |pages= 171–4 |year= 1994 |pmid= 8125298 |doi=
*cite journal | author=Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, "et al." |title=Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library. |journal=Gene |volume=200 |issue= 1-2 |pages= 149–56 |year= 1997 |pmid= 9373149 |doi=
*cite journal | author=Okamura-Oho Y, Miyashita T, Ohmi K, Yamada M |title=Dentatorubral-pallidoluysian atrophy protein interacts through a proline-rich region near polyglutamine with the SH3 domain of an insulin receptor tyrosine kinase substrate. |journal=Hum. Mol. Genet. |volume=8 |issue= 6 |pages= 947–57 |year= 1999 |pmid= 10332026 |doi=
*cite journal | author=Oda K, Shiratsuchi T, Nishimori H, "et al." |title=Identification of BAIAP2 (BAI-associated protein 2), a novel human homologue of hamster IRSp53, whose SH3 domain interacts with the cytoplasmic domain of BAI1. |journal=Cytogenet. Cell Genet. |volume=84 |issue= 1-2 |pages= 75–82 |year= 1999 |pmid= 10343108 |doi=
*cite journal | author=Abbott MA, Wells DG, Fallon JR |title=The insulin receptor tyrosine kinase substrate p58/53 and the insulin receptor are components of CNS synapses. |journal=J. Neurosci. |volume=19 |issue= 17 |pages= 7300–8 |year= 1999 |pmid= 10460236 |doi=
*cite journal | author=Fujiwara T, Mammoto A, Kim Y, Takai Y |title=Rho small G-protein-dependent binding of mDia to an Src homology 3 domain-containing IRSp53/BAIAP2. |journal=Biochem. Biophys. Res. Commun. |volume=271 |issue= 3 |pages= 626–9 |year= 2000 |pmid= 10814512 |doi= 10.1006/bbrc.2000.2671
*cite journal | author=Miki H, Yamaguchi H, Suetsugu S, Takenawa T |title=IRSp53 is an essential intermediate between Rac and WAVE in the regulation of membrane ruffling. |journal=Nature |volume=408 |issue= 6813 |pages= 732–5 |year= 2001 |pmid= 11130076 |doi= 10.1038/35047107
*cite journal | author=Govind S, Kozma R, Monfries C, "et al." |title=Cdc42Hs facilitates cytoskeletal reorganization and neurite outgrowth by localizing the 58-kD insulin receptor substrate to filamentous actin. |journal=J. Cell Biol. |volume=152 |issue= 3 |pages= 579–94 |year= 2001 |pmid= 11157984 |doi=
*cite journal | author=Krugmann S, Jordens I, Gevaert K, "et al." |title=Cdc42 induces filopodia by promoting the formation of an IRSp53:Mena complex. |journal=Curr. Biol. |volume=11 |issue= 21 |pages= 1645–55 |year= 2002 |pmid= 11696321 |doi=
*cite journal | author=Miki H, Takenawa T |title=WAVE2 serves a functional partner of IRSp53 by regulating its interaction with Rac. |journal=Biochem. Biophys. Res. Commun. |volume=293 |issue= 1 |pages= 93–9 |year= 2002 |pmid= 12054568 |doi= 10.1016/S0006-291X(02)00218-8
*cite journal | author=Strausberg RL, Feingold EA, Grouse LH, "et al." |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899
*cite journal | author=Soltau M, Richter D, Kreienkamp HJ |title=The insulin receptor substrate IRSp53 links postsynaptic shank1 to the small G-protein cdc42. |journal=Mol. Cell. Neurosci. |volume=21 |issue= 4 |pages= 575–83 |year= 2003 |pmid= 12504591 |doi=
*cite journal | author=Sekerková G, Loomis PA, Changyaleket B, "et al." |title=Novel espin actin-bundling proteins are localized to Purkinje cell dendritic spines and bind the Src homology 3 adapter protein insulin receptor substrate p53. |journal=J. Neurosci. |volume=23 |issue= 4 |pages= 1310–9 |year= 2003 |pmid= 12598619 |doi=
*cite journal | author=Miyahara A, Okamura-Oho Y, Miyashita T, "et al." |title=Genomic structure and alternative splicing of the insulin receptor tyrosine kinase substrate of 53-kDa protein. |journal=J. Hum. Genet. |volume=48 |issue= 8 |pages= 410–4 |year= 2003 |pmid= 12884081 |doi= 10.1007/s10038-003-0047-x
*cite journal | author=Hori K, Konno D, Maruoka H, Sobue K |title=MALS is a binding partner of IRSp53 at cell-cell contacts. |journal=FEBS Lett. |volume=554 |issue= 1-2 |pages= 30–4 |year= 2003 |pmid= 14596909 |doi=
*cite journal | author=Lehner B, Semple JI, Brown SE, "et al." |title=Analysis of a high-throughput yeast two-hybrid system and its use to predict the function of intracellular proteins encoded within the human MHC class III region. |journal=Genomics |volume=83 |issue= 1 |pages= 153–67 |year= 2004 |pmid= 14667819 |doi=
*cite journal | author=Ota T, Suzuki Y, Nishikawa T, "et al." |title=Complete sequencing and characterization of 21,243 full-length human cDNAs. |journal=Nat. Genet. |volume=36 |issue= 1 |pages= 40–5 |year= 2004 |pmid= 14702039 |doi= 10.1038/ng1285
*cite journal | author=Yamagishi A, Masuda M, Ohki T, "et al." |title=A novel actin bundling/filopodium-forming domain conserved in insulin receptor tyrosine kinase substrate p53 and missing in metastasis protein. |journal=J. Biol. Chem. |volume=279 |issue= 15 |pages= 14929–36 |year= 2004 |pmid= 14752106 |doi= 10.1074/jbc.M309408200
*cite journal | author=Funato Y, Terabayashi T, Suenaga N, "et al." |title=IRSp53/Eps8 complex is important for positive regulation of Rac and cancer cell motility/invasiveness. |journal=Cancer Res. |volume=64 |issue= 15 |pages= 5237–44 |year= 2004 |pmid= 15289329 |doi= 10.1158/0008-5472.CAN-04-0327
*cite journal | author=Jin J, Smith FD, Stark C, "et al." |title=Proteomic, functional, and domain-based analysis of in vivo 14-3-3 binding proteins involved in cytoskeletal regulation and cellular organization. |journal=Curr. Biol. |volume=14 |issue= 16 |pages= 1436–50 |year= 2004 |pmid= 15324660 |doi= 10.1016/j.cub.2004.07.051

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