CENPA


CENPA

Centromere protein A, also known as CENPA, is a human gene.cite web | title = Entrez Gene: CENPA centromere protein A| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=1058| accessdate = ]

PBB_Summary
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summary_text = Centromeres are the differentiated chromosomal domains that specify the mitotic behavior of chromosomes. CENPA encodes a centromere protein which contains a histone H3 related histone fold domain that is required for targeting to the centromere. CENPA is proposed to be a component of a modified nucleosome or nucleosome-like structure in which it replaces 1 or both copies of conventional histone H3 in the (H3-H4)2 tetrameric core of the nucleosome particle. Alternative splicing results in multiple transcript variants encoding distinct isoforms.cite web | title = Entrez Gene: CENPA centromere protein A| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=1058| accessdate = ]

References

Further reading

PBB_Further_reading
citations =
*cite journal | author=Palmer DK, O'Day K, Trong HL, "et al." |title=Purification of the centromere-specific protein CENP-A and demonstration that it is a distinctive histone. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=88 |issue= 9 |pages= 3734–8 |year= 1991 |pmid= 2023923 |doi=
*cite journal | author=Sullivan KF, Hechenberger M, Masri K |title=Human CENP-A contains a histone H3 related histone fold domain that is required for targeting to the centromere. |journal=J. Cell Biol. |volume=127 |issue= 3 |pages= 581–92 |year= 1994 |pmid= 7962047 |doi=
*cite journal | author=Shelby RD, Vafa O, Sullivan KF |title=Assembly of CENP-A into centromeric chromatin requires a cooperative array of nucleosomal DNA contact sites. |journal=J. Cell Biol. |volume=136 |issue= 3 |pages= 501–13 |year= 1997 |pmid= 9024683 |doi=
*cite journal | author=Valdivia MM, Figueroa J, Iglesias C, Ortíz M |title=A novel centromere monospecific serum to a human autoepitope on the histone H3-like protein CENP-A. |journal=FEBS Lett. |volume=422 |issue= 1 |pages= 5–9 |year= 1998 |pmid= 9475158 |doi=
*cite journal | author=Fowler KJ, Newson AJ, MacDonald AC, "et al." |title=Chromosomal localization of mouse Cenpa gene. |journal=Cytogenet. Cell Genet. |volume=79 |issue= 3-4 |pages= 298–301 |year= 1998 |pmid= 9605877 |doi=
*cite journal | author=Muro Y, Azuma N, Onouchi H, "et al." |title=Autoepitopes on autoantigen centromere protein-A (CENP-A) are restricted to the N-terminal region, which has no homology with histone H3. |journal=Clin. Exp. Immunol. |volume=120 |issue= 1 |pages= 218–23 |year= 2000 |pmid= 10759786 |doi=
*cite journal | author=Lomonte P, Sullivan KF, Everett RD |title=Degradation of nucleosome-associated centromeric histone H3-like protein CENP-A induced by herpes simplex virus type 1 protein ICP0. |journal=J. Biol. Chem. |volume=276 |issue= 8 |pages= 5829–35 |year= 2001 |pmid= 11053442 |doi= 10.1074/jbc.M008547200
*cite journal | author=Uren AG, Wong L, Pakusch M, "et al." |title=Survivin and the inner centromere protein INCENP show similar cell-cycle localization and gene knockout phenotype. |journal=Curr. Biol. |volume=10 |issue= 21 |pages= 1319–28 |year= 2001 |pmid= 11084331 |doi=
*cite journal | author=Zeitlin SG, Shelby RD, Sullivan KF |title=CENP-A is phosphorylated by Aurora B kinase and plays an unexpected role in completion of cytokinesis. |journal=J. Cell Biol. |volume=155 |issue= 7 |pages= 1147–57 |year= 2002 |pmid= 11756469 |doi= 10.1083/jcb.200108125
*cite journal | author=Ando S, Yang H, Nozaki N, "et al." |title=CENP-A, -B, and -C chromatin complex that contains the I-type alpha-satellite array constitutes the prekinetochore in HeLa cells. |journal=Mol. Cell. Biol. |volume=22 |issue= 7 |pages= 2229–41 |year= 2002 |pmid= 11884609 |doi=
*cite journal | author=Saxena A, Saffery R, Wong LH, "et al." |title=Centromere proteins Cenpa, Cenpb, and Bub3 interact with poly(ADP-ribose) polymerase-1 protein and are poly(ADP-ribosyl)ated. |journal=J. Biol. Chem. |volume=277 |issue= 30 |pages= 26921–6 |year= 2002 |pmid= 12011073 |doi= 10.1074/jbc.M200620200
*cite journal | author=Figueroa J, Pendón C, Valdivia MM |title=Molecular cloning and sequence analysis of hamster CENP-A cDNA. |journal=BMC Genomics |volume=3 |issue= 1 |pages= 11 |year= 2003 |pmid= 12019018 |doi=
*cite journal | author=Saxena A, Wong LH, Kalitsis P, "et al." |title=Poly(ADP-ribose) polymerase 2 localizes to mammalian active centromeres and interacts with PARP-1, Cenpa, Cenpb and Bub3, but not Cenpc. |journal=Hum. Mol. Genet. |volume=11 |issue= 19 |pages= 2319–29 |year= 2003 |pmid= 12217960 |doi=
*cite journal | author=Strausberg RL, Feingold EA, Grouse LH, "et al." |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899
*cite journal | author=Tomonaga T, Matsushita K, Yamaguchi S, "et al." |title=Overexpression and mistargeting of centromere protein-A in human primary colorectal cancer. |journal=Cancer Res. |volume=63 |issue= 13 |pages= 3511–6 |year= 2003 |pmid= 12839935 |doi=
*cite journal | author=Kunitoku N, Sasayama T, Marumoto T, "et al." |title=CENP-A phosphorylation by Aurora-A in prophase is required for enrichment of Aurora-B at inner centromeres and for kinetochore function. |journal=Dev. Cell |volume=5 |issue= 6 |pages= 853–64 |year= 2004 |pmid= 14667408 |doi=
*cite journal | author=Obuse C, Yang H, Nozaki N, "et al." |title=Proteomics analysis of the centromere complex from HeLa interphase cells: UV-damaged DNA binding protein 1 (DDB-1) is a component of the CEN-complex, while BMI-1 is transiently co-localized with the centromeric region in interphase. |journal=Genes Cells |volume=9 |issue= 2 |pages= 105–20 |year= 2004 |pmid= 15009096 |doi=
*cite journal | author=Yasuda S, Oceguera-Yanez F, Kato T, "et al." |title=Cdc42 and mDia3 regulate microtubule attachment to kinetochores. |journal=Nature |volume=428 |issue= 6984 |pages= 767–71 |year= 2004 |pmid= 15085137 |doi= 10.1038/nature02452
*cite journal | author=Black BE, Foltz DR, Chakravarthy S, "et al." |title=Structural determinants for generating centromeric chromatin. |journal=Nature |volume=430 |issue= 6999 |pages= 578–82 |year= 2004 |pmid= 15282608 |doi= 10.1038/nature02766
*cite journal | author=Sullivan BA, Karpen GH |title=Centromeric chromatin exhibits a histone modification pattern that is distinct from both euchromatin and heterochromatin. |journal=Nat. Struct. Mol. Biol. |volume=11 |issue= 11 |pages= 1076–83 |year= 2004 |pmid= 15475964 |doi= 10.1038/nsmb845

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