Phospholipase C, beta 1 (phosphoinositide-specific), also known as PLCB1, is a human gene.cite web | title = Entrez Gene: PLCB1 phospholipase C, beta 1 (phosphoinositide-specific)| url =| accessdate = ]

section_title =
summary_text = The protein encoded by this gene catalyzes the formation of inositol 1,4,5-trisphosphate and diacylglycerol from phosphatidylinositol 4,5-bisphosphate. This reaction uses calcium as a cofactor and plays an important role in the intracellular transduction of many extracellular signals. This gene is activated by two G-protein alpha subunits, alpha-q and alpha-11. Two transcript variants encoding different isoforms have been found for this gene.cite web | title = Entrez Gene: PLCB1 phospholipase C, beta 1 (phosphoinositide-specific)| url =| accessdate = ]


Further reading

citations =
*cite journal | author=Nakajima D, Okazaki N, Yamakawa H, "et al." |title=Construction of expression-ready cDNA clones for KIAA genes: manual curation of 330 KIAA cDNA clones. |journal=DNA Res. |volume=9 |issue= 3 |pages= 99–106 |year= 2003 |pmid= 12168954 |doi=
*cite journal | author=Martelli AM, Fiume R, Faenza I, "et al." |title=Nuclear phosphoinositide specific phospholipase C (PI-PLC)-beta 1: a central intermediary in nuclear lipid-dependent signal transduction. |journal=Histol. Histopathol. |volume=20 |issue= 4 |pages= 1251–60 |year= 2006 |pmid= 16136505 |doi=
*cite journal | author=Cocco L, Follo MY, Faenza I, "et al." |title=Nuclear inositide signaling: an appraisal of phospholipase C beta 1 behavior in myelodysplastic and leukemia cells. |journal=Adv. Enzyme Regul. |volume=47 |issue= |pages= 2–9 |year= 2007 |pmid= 17335878 |doi= 10.1016/j.advenzreg.2006.12.003
*cite journal | author=Cefai D, Debre P, Kaczorek M, "et al." |title=Human immunodeficiency virus-1 glycoproteins gp120 and gp160 specifically inhibit the CD3/T cell-antigen receptor phosphoinositide transduction pathway. |journal=J. Clin. Invest. |volume=86 |issue= 6 |pages= 2117–24 |year= 1991 |pmid= 1979339 |doi=
*cite journal | author=Zauli G, Previati M, Caramelli E, "et al." |title=Exogenous human immunodeficiency virus type-1 Tat protein selectively stimulates a phosphatidylinositol-specific phospholipase C nuclear pathway in the Jurkat T cell line. |journal=Eur. J. Immunol. |volume=25 |issue= 9 |pages= 2695–700 |year= 1995 |pmid= 7589147 |doi=
*cite journal | author=Hwang SC, Park KH, Ha MJ, "et al." |title=Distribution of phospholipase C isozymes in normal human lung tissue and their immunohistochemical localization. |journal=J. Korean Med. Sci. |volume=11 |issue= 4 |pages= 305–13 |year= 1997 |pmid= 8878798 |doi=
*cite journal | author=Chen P, Mayne M, Power C, Nath A |title=The Tat protein of HIV-1 induces tumor necrosis factor-alpha production. Implications for HIV-1-associated neurological diseases. |journal=J. Biol. Chem. |volume=272 |issue= 36 |pages= 22385–8 |year= 1997 |pmid= 9278385 |doi=
*cite journal | author=Nagase T, Ishikawa K, Miyajima N, "et al." |title=Prediction of the coding sequences of unidentified human genes. IX. The complete sequences of 100 new cDNA clones from brain which can code for large proteins in vitro. |journal=DNA Res. |volume=5 |issue= 1 |pages= 31–9 |year= 1998 |pmid= 9628581 |doi=
*cite journal | author=Snow BE, Hall RA, Krumins AM, "et al." |title=GTPase activating specificity of RGS12 and binding specificity of an alternatively spliced PDZ (PSD-95/Dlg/ZO-1) domain. |journal=J. Biol. Chem. |volume=273 |issue= 28 |pages= 17749–55 |year= 1998 |pmid= 9651375 |doi=
*cite journal | author=Mayne M, Bratanich AC, Chen P, "et al." |title=HIV-1 tat molecular diversity and induction of TNF-alpha: implications for HIV-induced neurological disease. |journal=Neuroimmunomodulation |volume=5 |issue= 3-4 |pages= 184–92 |year= 1998 |pmid= 9730685 |doi=
*cite journal | author=Haughey NJ, Holden CP, Nath A, Geiger JD |title=Involvement of inositol 1,4,5-trisphosphate-regulated stores of intracellular calcium in calcium dysregulation and neuron cell death caused by HIV-1 protein tat. |journal=J. Neurochem. |volume=73 |issue= 4 |pages= 1363–74 |year= 1999 |pmid= 10501179 |doi=
*cite journal | author=Peruzzi D, Calabrese G, Faenza I, "et al." |title=Identification and chromosomal localisation by fluorescence in situ hybridisation of human gene of phosphoinositide-specific phospholipase C beta(1). |journal=Biochim. Biophys. Acta |volume=1484 |issue= 2-3 |pages= 175–82 |year= 2000 |pmid= 10760467 |doi=
*cite journal | author=Mayne M, Holden CP, Nath A, Geiger JD |title=Release of calcium from inositol 1,4,5-trisphosphate receptor-regulated stores by HIV-1 Tat regulates TNF-alpha production in human macrophages. |journal=J. Immunol. |volume=164 |issue= 12 |pages= 6538–42 |year= 2000 |pmid= 10843712 |doi=
*cite journal | author=Tang Y, Tang J, Chen Z, "et al." |title=Association of mammalian trp4 and phospholipase C isozymes with a PDZ domain-containing protein, NHERF. |journal=J. Biol. Chem. |volume=275 |issue= 48 |pages= 37559–64 |year= 2001 |pmid= 10980202 |doi= 10.1074/jbc.M006635200
*cite journal | author=Caricasole A, Sala C, Roncarati R, "et al." |title=Cloning and characterization of the human phosphoinositide-specific phospholipase C-beta 1 (PLC beta 1). |journal=Biochim. Biophys. Acta |volume=1517 |issue= 1 |pages= 63–72 |year= 2001 |pmid= 11118617 |doi=
*cite journal | author=Dowal L, Elliott J, Popov S, "et al." |title=Determination of the contact energies between a regulator of G protein signaling and G protein subunits and phospholipase C beta 1. |journal=Biochemistry |volume=40 |issue= 2 |pages= 414–21 |year= 2001 |pmid= 11148035 |doi=
*cite journal | author=Xu A, Wang Y, Xu LY, Gilmour RS |title=Protein kinase C alpha -mediated negative feedback regulation is responsible for the termination of insulin-like growth factor I-induced activation of nuclear phospholipase C beta1 in Swiss 3T3 cells. |journal=J. Biol. Chem. |volume=276 |issue= 18 |pages= 14980–6 |year= 2001 |pmid= 11278470 |doi= 10.1074/jbc.M009144200
*cite journal | author=Xu A, Suh PG, Marmy-Conus N, "et al." |title=Phosphorylation of nuclear phospholipase C beta1 by extracellular signal-regulated kinase mediates the mitogenic action of insulin-like growth factor I. |journal=Mol. Cell. Biol. |volume=21 |issue= 9 |pages= 2981–90 |year= 2001 |pmid= 11287604 |doi= 10.1128/MCB.21.9.2981-2990.2001
*cite journal | author=Vitale M, Matteucci A, Manzoli L, "et al." |title=Interleukin 2 activates nuclear phospholipase Cbeta by mitogen-activated protein kinase-dependent phosphorylation in human natural killer cells. |journal=FASEB J. |volume=15 |issue= 10 |pages= 1789–91 |year= 2001 |pmid= 11481231 |doi=
*cite journal | author=Singer AU, Waldo GL, Harden TK, Sondek J |title=A unique fold of phospholipase C-beta mediates dimerization and interaction with G alpha q. |journal=Nat. Struct. Biol. |volume=9 |issue= 1 |pages= 32–6 |year= 2002 |pmid= 11753430 |doi= 10.1038/nsb731

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