Involucrin, also known as IVL, is a human gene.cite web | title = Entrez Gene: IVL involucrin| url =| accessdate = ]

section_title =
summary_text = Involucrin, a component of the keratinocyte crosslinked envelope, is found in the cytoplasm and crosslinked to membrane proteins by transglutaminase. This gene is mapped to 1q21, among calpactin I light chain, trichohyalin, profillaggrin, loricrin, and calcyclin.cite web | title = Entrez Gene: IVL involucrin| url =| accessdate = ]


Further reading

citations =
*cite journal | author=Eckert RL, Crish JF, Efimova T, "et al." |title=Regulation of involucrin gene expression. |journal=J. Invest. Dermatol. |volume=123 |issue= 1 |pages= 13–22 |year= 2004 |pmid= 15191537 |doi= 10.1111/j.0022-202X.2004.22723.x
*cite journal | author=Rice RH, Green H |title=Presence in human epidermal cells of a soluble protein precursor of the cross-linked envelope: activation of the cross-linking by calcium ions. |journal=Cell |volume=18 |issue= 3 |pages= 681–94 |year= 1980 |pmid= 42494 |doi=
*cite journal | author=Yaffe MB, Beegen H, Eckert RL |title=Biophysical characterization of involucrin reveals a molecule ideally suited to function as an intermolecular cross-bridge of the keratinocyte cornified envelope. |journal=J. Biol. Chem. |volume=267 |issue= 17 |pages= 12233–8 |year= 1992 |pmid= 1601889 |doi=
*cite journal | author=Simon M, Green H |title=The glutamine residues reactive in transglutaminase-catalyzed cross-linking of involucrin. |journal=J. Biol. Chem. |volume=263 |issue= 34 |pages= 18093–8 |year= 1989 |pmid= 2461365 |doi=
*cite journal | author=Eckert RL, Green H |title=Structure and evolution of the human involucrin gene. |journal=Cell |volume=46 |issue= 4 |pages= 583–9 |year= 1986 |pmid= 2873896 |doi=
*cite journal | author=Heller M, Flemington E, Kieff E, Deininger P |title=Repeat arrays in cellular DNA related to the Epstein-Barr virus IR3 repeat. |journal=Mol. Cell. Biol. |volume=5 |issue= 3 |pages= 457–65 |year= 1985 |pmid= 2985954 |doi=
*cite journal | author=Welter JF, Crish JF, Agarwal C, Eckert RL |title=Fos-related antigen (Fra-1), junB, and junD activate human involucrin promoter transcription by binding to proximal and distal AP1 sites to mediate phorbol ester effects on promoter activity. |journal=J. Biol. Chem. |volume=270 |issue= 21 |pages= 12614–22 |year= 1995 |pmid= 7759510 |doi=
*cite journal | author=Volz A, Korge BP, Compton JG, "et al." |title=Physical mapping of a functional cluster of epidermal differentiation genes on chromosome 1q21. |journal=Genomics |volume=18 |issue= 1 |pages= 92–9 |year= 1994 |pmid= 8276421 |doi= 10.1006/geno.1993.1430
*cite journal | author=Takahashi H, Iizuka H |title=Analysis of the 5'-upstream promoter region of human involucrin gene: activation by 12-O-tetradecanoylphorbol-13-acetate. |journal=J. Invest. Dermatol. |volume=100 |issue= 1 |pages= 10–5 |year= 1993 |pmid= 8380829 |doi=
*cite journal | author=Lopez-Bayghen E, Vega A, Cadena A, "et al." |title=Transcriptional analysis of the 5'-noncoding region of the human involucrin gene. |journal=J. Biol. Chem. |volume=271 |issue= 1 |pages= 512–20 |year= 1996 |pmid= 8550612 |doi=
*cite journal | author=Takahashi H, Kobayashi H, Matsuo S, Iizuka H |title=Repression of involucrin gene expression by transcriptional enhancer factor 1 (TEF-1). |journal=Arch. Dermatol. Res. |volume=287 |issue= 8 |pages= 740–6 |year= 1996 |pmid= 8554386 |doi=
*cite journal | author=Steinert PM, Marekov LN |title=Direct evidence that involucrin is a major early isopeptide cross-linked component of the keratinocyte cornified cell envelope. |journal=J. Biol. Chem. |volume=272 |issue= 3 |pages= 2021–30 |year= 1997 |pmid= 8999895 |doi=
*cite journal | author=Robinson NA, Lapic S, Welter JF, Eckert RL |title=S100A11, S100A10, annexin I, desmosomal proteins, small proline-rich proteins, plasminogen activator inhibitor-2, and involucrin are components of the cornified envelope of cultured human epidermal keratinocytes. |journal=J. Biol. Chem. |volume=272 |issue= 18 |pages= 12035–46 |year= 1997 |pmid= 9115270 |doi=
*cite journal | author=Ng DC, Su MJ, Kim R, Bikle DD |title=Regulation of involucrin gene expression by calcium in normal human keratinocytes. |journal=Front. Biosci. |volume=1 |issue= |pages= a16–24 |year= 2004 |pmid= 9159190 |doi=
*cite journal | author=Banks EB, Crish JF, Welter JF, Eckert RL |title=Characterization of human involucrin promoter distal regulatory region transcriptional activator elements-a role for Sp1 and AP1 binding sites. |journal=Biochem. J. |volume=331 ( Pt 1) |issue= |pages= 61–8 |year= 1998 |pmid= 9512462 |doi=
*cite journal | author=Marekov LN, Steinert PM |title=Ceramides are bound to structural proteins of the human foreskin epidermal cornified cell envelope. |journal=J. Biol. Chem. |volume=273 |issue= 28 |pages= 17763–70 |year= 1998 |pmid= 9651377 |doi=
*cite journal | author=Crish JF, Zaim TM, Eckert RL |title=The distal regulatory region of the human involucrin promoter is required for expression in epidermis. |journal=J. Biol. Chem. |volume=273 |issue= 46 |pages= 30460–5 |year= 1998 |pmid= 9804813 |doi=
*cite journal | author=Lee CH, Marekov LN, Kim S, "et al." |title=Small proline-rich protein 1 is the major component of the cell envelope of normal human oral keratinocytes. |journal=FEBS Lett. |volume=477 |issue= 3 |pages= 268–72 |year= 2000 |pmid= 10908733 |doi=
*cite journal | author=Candi E, Oddi S, Terrinoni A, "et al." |title=Transglutaminase 5 cross-links loricrin, involucrin, and small proline-rich proteins in vitro. |journal=J. Biol. Chem. |volume=276 |issue= 37 |pages= 35014–23 |year= 2001 |pmid= 11443109 |doi= 10.1074/jbc.M010157200
*cite journal | author=Crish JF, Bone F, Banks EB, Eckert RL |title=The human involucrin gene contains spatially distinct regulatory elements that regulate expression during early versus late epidermal differentiation. |journal=Oncogene |volume=21 |issue= 5 |pages= 738–47 |year= 2002 |pmid= 11850802 |doi= 10.1038/sj.onc.1205038

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