Histone deacetylase 5


Histone deacetylase 5

Histone deacetylase 5, also known as HDAC5, is a human gene.cite web | title = Entrez Gene: HDAC5 histone deacetylase 5| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=10014| accessdate = ]

PBB_Summary
section_title =
summary_text = Histones play a critical role in transcriptional regulation, cell cycle progression, and developmental events. Histone acetylation/deacetylation alters chromosome structure and affects transcription factor access to DNA. The protein encoded by this gene belongs to the class II histone deacetylase/acuc/apha family. It possesses histone deacetylase activity and represses transcription when tethered to a promoter. It coimmunoprecipitates only with HDAC3 family member and might form multicomplex proteins. It also interacts with myocyte enhancer factor-2 (MEF2) proteins, resulting in repression of MEF2-dependent genes. This gene is thought to be associated with colon cancer. Two transcript variants encoding different isoforms have been found for this gene.cite web | title = Entrez Gene: HDAC5 histone deacetylase 5| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=10014| accessdate = ]

ee also

* Histone deacetylase

References

Further reading

PBB_Further_reading
citations =
*cite journal | author=Nakajima D, Okazaki N, Yamakawa H, "et al." |title=Construction of expression-ready cDNA clones for KIAA genes: manual curation of 330 KIAA cDNA clones. |journal=DNA Res. |volume=9 |issue= 3 |pages= 99–106 |year= 2003 |pmid= 12168954 |doi=
*cite journal | author=Verdin E, Dequiedt F, Kasler HG |title=Class II histone deacetylases: versatile regulators. |journal=Trends Genet. |volume=19 |issue= 5 |pages= 286–93 |year= 2003 |pmid= 12711221 |doi=
*cite journal | author=Scanlan MJ, Chen YT, Williamson B, "et al." |title=Characterization of human colon cancer antigens recognized by autologous antibodies. |journal=Int. J. Cancer |volume=76 |issue= 5 |pages= 652–8 |year= 1998 |pmid= 9610721 |doi=
*cite journal | author=Nagase T, Ishikawa K, Miyajima N, "et al." |title=Prediction of the coding sequences of unidentified human genes. IX. The complete sequences of 100 new cDNA clones from brain which can code for large proteins in vitro. |journal=DNA Res. |volume=5 |issue= 1 |pages= 31–9 |year= 1998 |pmid= 9628581 |doi=
*cite journal | author=Grozinger CM, Hassig CA, Schreiber SL |title=Three proteins define a class of human histone deacetylases related to yeast Hda1p. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=96 |issue= 9 |pages= 4868–73 |year= 1999 |pmid= 10220385 |doi=
*cite journal | author=Huang EY, Zhang J, Miska EA, "et al." |title=Nuclear receptor corepressors partner with class II histone deacetylases in a Sin3-independent repression pathway. |journal=Genes Dev. |volume=14 |issue= 1 |pages= 45–54 |year= 2000 |pmid= 10640275 |doi=
*cite journal | author=Lemercier C, Verdel A, Galloo B, "et al." |title=mHDA1/HDAC5 histone deacetylase interacts with and represses MEF2A transcriptional activity. |journal=J. Biol. Chem. |volume=275 |issue= 20 |pages= 15594–9 |year= 2000 |pmid= 10748098 |doi= 10.1074/jbc.M908437199
*cite journal | author=Grozinger CM, Schreiber SL |title=Regulation of histone deacetylase 4 and 5 and transcriptional activity by 14-3-3-dependent cellular localization. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=97 |issue= 14 |pages= 7835–40 |year= 2000 |pmid= 10869435 |doi= 10.1073/pnas.140199597
*cite journal | author=Huynh KD, Fischle W, Verdin E, Bardwell VJ |title=BCoR, a novel corepressor involved in BCL-6 repression. |journal=Genes Dev. |volume=14 |issue= 14 |pages= 1810–23 |year= 2000 |pmid= 10898795 |doi=
*cite journal | author=Mahlknecht U, Schnittger S, Ottmann OG, "et al." |title=Chromosomal organization and localization of the human histone deacetylase 5 gene (HDAC5). |journal=Biochim. Biophys. Acta |volume=1493 |issue= 3 |pages= 342–8 |year= 2000 |pmid= 11018260 |doi=
*cite journal | author=Zhang CL, McKinsey TA, Lu JR, Olson EN |title=Association of COOH-terminal-binding protein (CtBP) and MEF2-interacting transcription repressor (MITR) contributes to transcriptional repression of the MEF2 transcription factor. |journal=J. Biol. Chem. |volume=276 |issue= 1 |pages= 35–9 |year= 2001 |pmid= 11022042 |doi= 10.1074/jbc.M007364200
*cite journal | author=McKinsey TA, Zhang CL, Lu J, Olson EN |title=Signal-dependent nuclear export of a histone deacetylase regulates muscle differentiation. |journal=Nature |volume=408 |issue= 6808 |pages= 106–11 |year= 2000 |pmid= 11081517 |doi= 10.1038/35040593
*cite journal | author=McKinsey TA, Zhang CL, Olson EN |title=Activation of the myocyte enhancer factor-2 transcription factor by calcium/calmodulin-dependent protein kinase-stimulated binding of 14-3-3 to histone deacetylase 5. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=97 |issue= 26 |pages= 14400–5 |year= 2001 |pmid= 11114197 |doi= 10.1073/pnas.260501497
*cite journal | author=Fischle W, Dequiedt F, Fillion M, "et al." |title=Human HDAC7 histone deacetylase activity is associated with HDAC3 in vivo. |journal=J. Biol. Chem. |volume=276 |issue= 38 |pages= 35826–35 |year= 2001 |pmid= 11466315 |doi= 10.1074/jbc.M104935200
*cite journal | author=McKinsey TA, Zhang CL, Olson EN |title=Identification of a signal-responsive nuclear export sequence in class II histone deacetylases. |journal=Mol. Cell. Biol. |volume=21 |issue= 18 |pages= 6312–21 |year= 2001 |pmid= 11509672 |doi=
*cite journal | author=Ozawa Y, Towatari M, Tsuzuki S, "et al." |title=Histone deacetylase 3 associates with and represses the transcription factor GATA-2. |journal=Blood |volume=98 |issue= 7 |pages= 2116–23 |year= 2001 |pmid= 11567998 |doi=
*cite journal | author=Potter GB, Beaudoin GM, DeRenzo CL, "et al." |title=The hairless gene mutated in congenital hair loss disorders encodes a novel nuclear receptor corepressor. |journal=Genes Dev. |volume=15 |issue= 20 |pages= 2687–701 |year= 2001 |pmid= 11641275 |doi= 10.1101/gad.916701
*cite journal | author=Fischle W, Dequiedt F, Hendzel MJ, "et al." |title=Enzymatic activity associated with class II HDACs is dependent on a multiprotein complex containing HDAC3 and SMRT/N-CoR. |journal=Mol. Cell |volume=9 |issue= 1 |pages= 45–57 |year= 2002 |pmid= 11804585 |doi=
*cite journal | author=Lemercier C, Brocard MP, Puvion-Dutilleul F, "et al." |title=Class II histone deacetylases are directly recruited by BCL6 transcriptional repressor. |journal=J. Biol. Chem. |volume=277 |issue= 24 |pages= 22045–52 |year= 2002 |pmid= 11929873 |doi= 10.1074/jbc.M201736200
*cite journal | author=Huang Y, Tan M, Gosink M, "et al." |title=Histone deacetylase 5 is not a p53 target gene, but its overexpression inhibits tumor cell growth and induces apoptosis. |journal=Cancer Res. |volume=62 |issue= 10 |pages= 2913–22 |year= 2002 |pmid= 12019172 |doi=

External links

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Look at other dictionaries:

  • Histone deacetylase — Histone deacetylases (HDAC) (EC number 3.5.1) are a class of enzymes that remove acetyl groups from an ε N acetyl lysine amino acid on a histone. Its action is opposite to that of histone acetyltransferase.ubtypesHDAC proteins are found in three… …   Wikipedia

  • Histone deacetylase 2 — Histone deacetylase 2, also known as HDAC2, is a human gene. PBB Summary section title = summary text = This gene product belongs to the histone deacetylase family. Histone deacetylases act via the formation of large multiprotein complexes and… …   Wikipedia

  • histone deacetylase — noun Any of a class of enzymes that remove acetyl groups from lysine amino acids in proteins, especially the histone proteins of the nucleus …   Wiktionary

  • histone deacetylase — his·tone de·ace·tyl·ase (hisґtōn de″ə seґtil ās) [EC 3.5.1.48] any of a group of enzymes that remove an acetyl group from histone and thus allow it to bind DNA and inhibit transcription …   Medical dictionary

  • histone deacetylase — HDAC. An enzyme that changes the way histone binds to DNA. HDAC inhibitors are being studied as a treatment for cancer …   English dictionary of cancer terms

  • Histone deacetylase inhibitor — Histone deacetylase inhibitors (HDAC inhibitors, HDI) are a class of compounds that interfere with the function of histone deacetylase.Cellular Biochemistry / PharmacologyTo carry out gene expression, a cell must control the coiling and uncoiling …   Wikipedia

  • histone deacetylase inhibitor — HDAC inhibitor. A substance that causes a chemical change that stops tumor cells from dividing. HDAC inhibitors are being studied in the treatment of cancer. Also called HDAC inhibitor …   English dictionary of cancer terms

  • Histone — In biology, histones are the chief protein components of chromatin. They act as spools around which DNA winds, and they play a role in gene regulation. Without histones, the unwound DNA in chromosomes would be very long. For example, each human… …   Wikipedia

  • Histone-Modifying Enzymes — The packaging of the eukaryotic genome into highly condensed chromatin makes it inaccessible to the factors required for gene transcription, DNA replication, recombination and repair. Eukaryotes have developed intricate mechanisms to overcome… …   Wikipedia

  • Histone acetyltransferase — protein Name=Histone Acetyltransferase 1 caption= width= HGNCid=4821 Symbol=HAT1 AltSymbols= EntrezGene=8520 OMIM=603053 RefSeq=NM 003642 UniProt=O14929 PDB= ECnumber=2.3.1.48 Chromosome=2 Arm=q Band=31.2 33.1 LocusSupplementaryData=Histone… …   Wikipedia


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