Histone deacetylase 5

Histone deacetylase 5

Histone deacetylase 5, also known as HDAC5, is a human gene.cite web | title = Entrez Gene: HDAC5 histone deacetylase 5| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=10014| accessdate = ]

section_title =
summary_text = Histones play a critical role in transcriptional regulation, cell cycle progression, and developmental events. Histone acetylation/deacetylation alters chromosome structure and affects transcription factor access to DNA. The protein encoded by this gene belongs to the class II histone deacetylase/acuc/apha family. It possesses histone deacetylase activity and represses transcription when tethered to a promoter. It coimmunoprecipitates only with HDAC3 family member and might form multicomplex proteins. It also interacts with myocyte enhancer factor-2 (MEF2) proteins, resulting in repression of MEF2-dependent genes. This gene is thought to be associated with colon cancer. Two transcript variants encoding different isoforms have been found for this gene.cite web | title = Entrez Gene: HDAC5 histone deacetylase 5| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=10014| accessdate = ]

ee also

* Histone deacetylase


Further reading

citations =
*cite journal | author=Nakajima D, Okazaki N, Yamakawa H, "et al." |title=Construction of expression-ready cDNA clones for KIAA genes: manual curation of 330 KIAA cDNA clones. |journal=DNA Res. |volume=9 |issue= 3 |pages= 99–106 |year= 2003 |pmid= 12168954 |doi=
*cite journal | author=Verdin E, Dequiedt F, Kasler HG |title=Class II histone deacetylases: versatile regulators. |journal=Trends Genet. |volume=19 |issue= 5 |pages= 286–93 |year= 2003 |pmid= 12711221 |doi=
*cite journal | author=Scanlan MJ, Chen YT, Williamson B, "et al." |title=Characterization of human colon cancer antigens recognized by autologous antibodies. |journal=Int. J. Cancer |volume=76 |issue= 5 |pages= 652–8 |year= 1998 |pmid= 9610721 |doi=
*cite journal | author=Nagase T, Ishikawa K, Miyajima N, "et al." |title=Prediction of the coding sequences of unidentified human genes. IX. The complete sequences of 100 new cDNA clones from brain which can code for large proteins in vitro. |journal=DNA Res. |volume=5 |issue= 1 |pages= 31–9 |year= 1998 |pmid= 9628581 |doi=
*cite journal | author=Grozinger CM, Hassig CA, Schreiber SL |title=Three proteins define a class of human histone deacetylases related to yeast Hda1p. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=96 |issue= 9 |pages= 4868–73 |year= 1999 |pmid= 10220385 |doi=
*cite journal | author=Huang EY, Zhang J, Miska EA, "et al." |title=Nuclear receptor corepressors partner with class II histone deacetylases in a Sin3-independent repression pathway. |journal=Genes Dev. |volume=14 |issue= 1 |pages= 45–54 |year= 2000 |pmid= 10640275 |doi=
*cite journal | author=Lemercier C, Verdel A, Galloo B, "et al." |title=mHDA1/HDAC5 histone deacetylase interacts with and represses MEF2A transcriptional activity. |journal=J. Biol. Chem. |volume=275 |issue= 20 |pages= 15594–9 |year= 2000 |pmid= 10748098 |doi= 10.1074/jbc.M908437199
*cite journal | author=Grozinger CM, Schreiber SL |title=Regulation of histone deacetylase 4 and 5 and transcriptional activity by 14-3-3-dependent cellular localization. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=97 |issue= 14 |pages= 7835–40 |year= 2000 |pmid= 10869435 |doi= 10.1073/pnas.140199597
*cite journal | author=Huynh KD, Fischle W, Verdin E, Bardwell VJ |title=BCoR, a novel corepressor involved in BCL-6 repression. |journal=Genes Dev. |volume=14 |issue= 14 |pages= 1810–23 |year= 2000 |pmid= 10898795 |doi=
*cite journal | author=Mahlknecht U, Schnittger S, Ottmann OG, "et al." |title=Chromosomal organization and localization of the human histone deacetylase 5 gene (HDAC5). |journal=Biochim. Biophys. Acta |volume=1493 |issue= 3 |pages= 342–8 |year= 2000 |pmid= 11018260 |doi=
*cite journal | author=Zhang CL, McKinsey TA, Lu JR, Olson EN |title=Association of COOH-terminal-binding protein (CtBP) and MEF2-interacting transcription repressor (MITR) contributes to transcriptional repression of the MEF2 transcription factor. |journal=J. Biol. Chem. |volume=276 |issue= 1 |pages= 35–9 |year= 2001 |pmid= 11022042 |doi= 10.1074/jbc.M007364200
*cite journal | author=McKinsey TA, Zhang CL, Lu J, Olson EN |title=Signal-dependent nuclear export of a histone deacetylase regulates muscle differentiation. |journal=Nature |volume=408 |issue= 6808 |pages= 106–11 |year= 2000 |pmid= 11081517 |doi= 10.1038/35040593
*cite journal | author=McKinsey TA, Zhang CL, Olson EN |title=Activation of the myocyte enhancer factor-2 transcription factor by calcium/calmodulin-dependent protein kinase-stimulated binding of 14-3-3 to histone deacetylase 5. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=97 |issue= 26 |pages= 14400–5 |year= 2001 |pmid= 11114197 |doi= 10.1073/pnas.260501497
*cite journal | author=Fischle W, Dequiedt F, Fillion M, "et al." |title=Human HDAC7 histone deacetylase activity is associated with HDAC3 in vivo. |journal=J. Biol. Chem. |volume=276 |issue= 38 |pages= 35826–35 |year= 2001 |pmid= 11466315 |doi= 10.1074/jbc.M104935200
*cite journal | author=McKinsey TA, Zhang CL, Olson EN |title=Identification of a signal-responsive nuclear export sequence in class II histone deacetylases. |journal=Mol. Cell. Biol. |volume=21 |issue= 18 |pages= 6312–21 |year= 2001 |pmid= 11509672 |doi=
*cite journal | author=Ozawa Y, Towatari M, Tsuzuki S, "et al." |title=Histone deacetylase 3 associates with and represses the transcription factor GATA-2. |journal=Blood |volume=98 |issue= 7 |pages= 2116–23 |year= 2001 |pmid= 11567998 |doi=
*cite journal | author=Potter GB, Beaudoin GM, DeRenzo CL, "et al." |title=The hairless gene mutated in congenital hair loss disorders encodes a novel nuclear receptor corepressor. |journal=Genes Dev. |volume=15 |issue= 20 |pages= 2687–701 |year= 2001 |pmid= 11641275 |doi= 10.1101/gad.916701
*cite journal | author=Fischle W, Dequiedt F, Hendzel MJ, "et al." |title=Enzymatic activity associated with class II HDACs is dependent on a multiprotein complex containing HDAC3 and SMRT/N-CoR. |journal=Mol. Cell |volume=9 |issue= 1 |pages= 45–57 |year= 2002 |pmid= 11804585 |doi=
*cite journal | author=Lemercier C, Brocard MP, Puvion-Dutilleul F, "et al." |title=Class II histone deacetylases are directly recruited by BCL6 transcriptional repressor. |journal=J. Biol. Chem. |volume=277 |issue= 24 |pages= 22045–52 |year= 2002 |pmid= 11929873 |doi= 10.1074/jbc.M201736200
*cite journal | author=Huang Y, Tan M, Gosink M, "et al." |title=Histone deacetylase 5 is not a p53 target gene, but its overexpression inhibits tumor cell growth and induces apoptosis. |journal=Cancer Res. |volume=62 |issue= 10 |pages= 2913–22 |year= 2002 |pmid= 12019172 |doi=

External links


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Look at other dictionaries:

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