Sodium/proton antiporter 1

Sodium/proton antiporter 1

Symbol = Na_H_antiport_1
Name = Na+/H+ antiporter 1

width =
caption =
Pfam= PF06965
InterPro= IPR004670
Prosite =
TCDB = 2.A.36
OPM family= 66
OPM protein= 1zcd

Na+/H+ antiporter 1 family contains a number of bacterial Na+/H+ antiporter 1 proteins. These are integral membrane proteins that catalyse the exchange of H+ for Na+ in a manner that is highly dependent on the pH [1] .

In paricular, the "Escherichia coli" NhaA Na+:H+ Antiporter (NhaA) protein probably functions in the regulation of the internal pH when the external pH is alkaline. It also uses the H+ gradient to expel Na+ from the cell. Its activity is highly pH dependent.


* [1] . Expression of a sodium proton antiporter (NhaA) in Escherichia coli is induced by Na+ and Li+ ions. Karpel R, Alon T, Glaser G, Schuldiner S, Padan E; J Biol Chem 1991;266:21753-21759. PMID|1657980

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