COL4A2

COL4A2

Collagen, type IV, alpha 2, also known as COL4A2, is a human gene.cite web | title = Entrez Gene: COL4A2 collagen, type IV, alpha 2| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=1284| accessdate = ]

PBB_Summary
section_title =
summary_text = This gene encodes one of the six subunits of type IV collagen, the major structural component of basement membranes. The C-terminal portion of the protein, known as canstatin, is an inhibitor of angiogenesis and tumor growth. Like the other members of the type IV collagen gene family, this gene is organized in a head-to-head conformation with another type IV collagen gene so that each gene pair shares a common promoter.cite web | title = Entrez Gene: COL4A2 collagen, type IV, alpha 2| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=1284| accessdate = ]

References

Further reading

PBB_Further_reading
citations =
*cite journal | author=Hinek A |title=Nature and the multiple functions of the 67-kD elastin-/laminin binding protein. |journal=Cell Adhes. Commun. |volume=2 |issue= 3 |pages= 185–93 |year= 1995 |pmid= 7827955 |doi=
*cite journal | author=Ständer M, Naumann U, Wick W, Weller M |title=Transforming growth factor-beta and p-21: multiple molecular targets of decorin-mediated suppression of neoplastic growth. |journal=Cell Tissue Res. |volume=296 |issue= 2 |pages= 221–7 |year= 1999 |pmid= 10382266 |doi=
*cite journal | author=Kurpakus Wheater M, Kernacki KA, Hazlett LD |title=Corneal cell proteins and ocular surface pathology. |journal=Biotechnic & histochemistry : official publication of the Biological Stain Commission |volume=74 |issue= 3 |pages= 146–59 |year= 1999 |pmid= 10416788 |doi=
*cite journal | author=Kalluri R, Sukhatme VP |title=Fibrosis and angiogenesis. |journal=Curr. Opin. Nephrol. Hypertens. |volume=9 |issue= 4 |pages= 413–8 |year= 2000 |pmid= 10926178 |doi=
*cite journal | author=Ghebrehiwet B, Peerschke EI, Hong Y, "et al." |title=Short amino acid sequences derived from C1q receptor (C1q-R) show homology with the alpha chains of fibronectin and vitronectin receptors and collagen type IV. |journal=J. Leukoc. Biol. |volume=51 |issue= 6 |pages= 546–56 |year= 1992 |pmid= 1377218 |doi=
*cite journal | author=Gupta S, Batchu RB, Datta K |title=Purification, partial characterization of rat kidney hyaluronic acid binding protein and its localization on the cell surface. |journal=Eur. J. Cell Biol. |volume=56 |issue= 1 |pages= 58–67 |year= 1992 |pmid= 1724753 |doi=
*cite journal | author=Paralkar VM, Nandedkar AK, Pointer RH, "et al." |title=Interaction of osteogenin, a heparin binding bone morphogenetic protein, with type IV collagen. |journal=J. Biol. Chem. |volume=265 |issue= 28 |pages= 17281–4 |year= 1990 |pmid= 2211625 |doi=
*cite journal | author=Hernandez MR, Igoe F, Neufeld AH |title=Extracellular matrix of the human optic nerve head. |journal=Am. J. Ophthalmol. |volume=102 |issue= 2 |pages= 139–48 |year= 1986 |pmid= 2426947 |doi=
*cite journal | author=Myers JC, Howard PS, Jelen AM, "et al." |title=Duplication of type IV collagen COOH-terminal repeats and species-specific expression of alpha 1(IV) and alpha 2(IV) collagen genes. |journal=J. Biol. Chem. |volume=262 |issue= 19 |pages= 9231–8 |year= 1987 |pmid= 2439508 |doi=
*cite journal | author=Siebold B, Deutzmann R, Kühn K |title=The arrangement of intra- and intermolecular disulfide bonds in the carboxyterminal, non-collagenous aggregation and cross-linking domain of basement-membrane type IV collagen. |journal=Eur. J. Biochem. |volume=176 |issue= 3 |pages= 617–24 |year= 1988 |pmid= 2844531 |doi=
*cite journal | author=Pöschl E, Pollner R, Kühn K |title=The genes for the alpha 1(IV) and alpha 2(IV) chains of human basement membrane collagen type IV are arranged head-to-head and separated by a bidirectional promoter of unique structure. |journal=EMBO J. |volume=7 |issue= 9 |pages= 2687–95 |year= 1988 |pmid= 2846280 |doi=
*cite journal | author=Griffin CA, Emanuel BS, Hansen JR, "et al." |title=Human collagen genes encoding basement membrane alpha 1 (IV) and alpha 2 (IV) chains map to the distal long arm of chromosome 13. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=84 |issue= 2 |pages= 512–6 |year= 1987 |pmid= 3025878 |doi=
*cite journal | author=Murata K, Motayama T, Kotake C |title=Collagen types in various layers of the human aorta and their changes with the atherosclerotic process. |journal=Atherosclerosis |volume=60 |issue= 3 |pages= 251–62 |year= 1986 |pmid= 3089234 |doi=
*cite journal | author=Soininen R, Huotari M, Hostikka SL, "et al." |title=The structural genes for alpha 1 and alpha 2 chains of human type IV collagen are divergently encoded on opposite DNA strands and have an overlapping promoter region. |journal=J. Biol. Chem. |volume=263 |issue= 33 |pages= 17217–20 |year= 1988 |pmid= 3182844 |doi=
*cite journal | author=Hostikka SL, Tryggvason K |title=The complete primary structure of the alpha 2 chain of human type IV collagen and comparison with the alpha 1(IV) chain. |journal=J. Biol. Chem. |volume=263 |issue= 36 |pages= 19488–93 |year= 1989 |pmid= 3198637 |doi=
*cite journal | author=Brazel D, Pollner R, Oberbäumer I, Kühn K |title=Human basement membrane collagen (type IV). The amino acid sequence of the alpha 2(IV) chain and its comparison with the alpha 1(IV) chain reveals deletions in the alpha 1(IV) chain. |journal=Eur. J. Biochem. |volume=172 |issue= 1 |pages= 35–42 |year= 1988 |pmid= 3345760 |doi=
*cite journal | author=Hostikka SL, Kurkinen M, Tryggvason K |title=Nucleotide sequence coding for the human type IV collagen alpha 2 chain cDNA reveals extensive homology with the NC-1 domain of alpha 1 (IV) but not with the collagenous domain or 3'-untranslated region. |journal=FEBS Lett. |volume=216 |issue= 2 |pages= 281–6 |year= 1987 |pmid= 3582677 |doi=
*cite journal | author=Killen PD, Francomano CA, Yamada Y, "et al." |title=Partial structure of the human alpha 2(IV) collagen chain and chromosomal localization of the gene (COL4A2). |journal=Hum. Genet. |volume=77 |issue= 4 |pages= 318–24 |year= 1988 |pmid= 3692475 |doi=
*cite journal | author=Glant TT, Hadházy C, Mikecz K, Sipos A |title=Appearance and persistence of fibronectin in cartilage. Specific interaction of fibronectin with collagen type II. |journal=Histochemistry |volume=82 |issue= 2 |pages= 149–58 |year= 1985 |pmid= 3997552 |doi=
*cite journal | author=Uscanga L, Kennedy RH, Stocker S, "et al." |title=Immunolocalization of collagen types, laminin and fibronectin in the normal human pancreas. |journal=Digestion |volume=30 |issue= 3 |pages= 158–64 |year= 1984 |pmid= 6389236 |doi=

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