VAMP2


VAMP2

Vesicle-associated membrane protein 2 (synaptobrevin 2), also known as VAMP2, is a human gene.cite web | title = Entrez Gene: VAMP2 vesicle-associated membrane protein 2 (synaptobrevin 2)| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=6844| accessdate = ]

PBB_Summary
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summary_text = Synaptobrevins/VAMPs, syntaxins, and the 25-kD synaptosomal-associated protein SNAP25 are the main components of a protein complex involved in the docking and/or fusion of synaptic vesicles with the presynaptic membrane. VAMP2 is a member of the vesicle-associated membrane protein (VAMP)/synaptobrevin family. VAMP2 is a likely candidate gene for familial infantile myasthenia (FIMG) because of its map location and because it encodes a synaptic vesicle protein of the type that has been implicated in the pathogenesis of FIMG. VAMP2 is thought to participate in neurotransmitter release at a step between docking and fusion. The protein forms a stable complex with syntaxin, synaptosomal-associated protein, 25 kD, and synaptotagmin. It also forms a distinct complex with synaptophysin.cite web | title = Entrez Gene: VAMP2 vesicle-associated membrane protein 2 (synaptobrevin 2)| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=6844| accessdate = ]

References

Further reading

PBB_Further_reading
citations =
*cite journal | author=Archer BT, Ozçelik T, Jahn R, "et al." |title=Structures and chromosomal localizations of two human genes encoding synaptobrevins 1 and 2. |journal=J. Biol. Chem. |volume=265 |issue= 28 |pages= 17267–73 |year= 1990 |pmid= 1976629 |doi=
*cite journal | author=Brumell JH, Volchuk A, Sengelov H, "et al." |title=Subcellular distribution of docking/fusion proteins in neutrophils, secretory cells with multiple exocytic compartments. |journal=J. Immunol. |volume=155 |issue= 12 |pages= 5750–9 |year= 1996 |pmid= 7499863 |doi=
*cite journal | author=Kutay U, Ahnert-Hilger G, Hartmann E, "et al." |title=Transport route for synaptobrevin via a novel pathway of insertion into the endoplasmic reticulum membrane. |journal=EMBO J. |volume=14 |issue= 2 |pages= 217–23 |year= 1995 |pmid= 7835332 |doi=
*cite journal | author=Chapman ER, An S, Barton N, Jahn R |title=SNAP-25, a t-SNARE which binds to both syntaxin and synaptobrevin via domains that may form coiled coils. |journal=J. Biol. Chem. |volume=269 |issue= 44 |pages= 27427–32 |year= 1994 |pmid= 7961655 |doi=
*cite journal | author=Hunt JM, Bommert K, Charlton MP, "et al." |title=A post-docking role for synaptobrevin in synaptic vesicle fusion. |journal=Neuron |volume=12 |issue= 6 |pages= 1269–79 |year= 1994 |pmid= 8011337 |doi=
*cite journal | author=Maruyama K, Sugano S |title=Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides. |journal=Gene |volume=138 |issue= 1-2 |pages= 171–4 |year= 1994 |pmid= 8125298 |doi=
*cite journal | author=Jagadish MN, Fernandez CS, Hewish DR, "et al." |title=Insulin-responsive tissues contain the core complex protein SNAP-25 (synaptosomal-associated protein 25) A and B isoforms in addition to syntaxin 4 and synaptobrevins 1 and 2. |journal=Biochem. J. |volume=317 ( Pt 3) |issue= |pages= 945–54 |year= 1996 |pmid= 8760387 |doi=
*cite journal | author=Mandon B, Chou CL, Nielsen S, Knepper MA |title=Syntaxin-4 is localized to the apical plasma membrane of rat renal collecting duct cells: possible role in aquaporin-2 trafficking. |journal=J. Clin. Invest. |volume=98 |issue= 4 |pages= 906–13 |year= 1996 |pmid= 8770861 |doi=
*cite journal | author=Timmers KI, Clark AE, Omatsu-Kanbe M, "et al." |title=Identification of SNAP receptors in rat adipose cell membrane fractions and in SNARE complexes co-immunoprecipitated with epitope-tagged N-ethylmaleimide-sensitive fusion protein. |journal=Biochem. J. |volume=320 ( Pt 2) |issue= |pages= 429–36 |year= 1997 |pmid= 8973549 |doi=
*cite journal | author=Betz A, Okamoto M, Benseler F, Brose N |title=Direct interaction of the rat unc-13 homologue Munc13-1 with the N terminus of syntaxin. |journal=J. Biol. Chem. |volume=272 |issue= 4 |pages= 2520–6 |year= 1997 |pmid= 8999968 |doi=
*cite journal | author=Hao JC, Salem N, Peng XR, "et al." |title=Effect of mutations in vesicle-associated membrane protein (VAMP) on the assembly of multimeric protein complexes. |journal=J. Neurosci. |volume=17 |issue= 5 |pages= 1596–603 |year= 1997 |pmid= 9030619 |doi=
*cite journal | author=Martincic I, Peralta ME, Ngsee JK |title=Isolation and characterization of a dual prenylated Rab and VAMP2 receptor. |journal=J. Biol. Chem. |volume=272 |issue= 43 |pages= 26991–8 |year= 1997 |pmid= 9341137 |doi=
*cite journal | author=Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, "et al." |title=Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library. |journal=Gene |volume=200 |issue= 1-2 |pages= 149–56 |year= 1997 |pmid= 9373149 |doi=
*cite journal | author=Weir ML, Klip A, Trimble WS |title=Identification of a human homologue of the vesicle-associated membrane protein (VAMP)-associated protein of 33 kDa (VAP-33): a broadly expressed protein that binds to VAMP. |journal=Biochem. J. |volume=333 ( Pt 2) |issue= |pages= 247–51 |year= 1998 |pmid= 9657962 |doi=
*cite journal | author=Isenmann S, Khew-Goodall Y, Gamble J, "et al." |title=A splice-isoform of vesicle-associated membrane protein-1 (VAMP-1) contains a mitochondrial targeting signal. |journal=Mol. Biol. Cell |volume=9 |issue= 7 |pages= 1649–60 |year= 1999 |pmid= 9658161 |doi=
*cite journal | author=Prekeris R, Klumperman J, Chen YA, Scheller RH |title=Syntaxin 13 mediates cycling of plasma membrane proteins via tubulovesicular recycling endosomes. |journal=J. Cell Biol. |volume=143 |issue= 4 |pages= 957–71 |year= 1998 |pmid= 9817754 |doi=
*cite journal | author=Nishimura Y, Hayashi M, Inada H, Tanaka T |title=Molecular cloning and characterization of mammalian homologues of vesicle-associated membrane protein-associated (VAMP-associated) proteins. |journal=Biochem. Biophys. Res. Commun. |volume=254 |issue= 1 |pages= 21–6 |year= 1999 |pmid= 9920726 |doi= 10.1006/bbrc.1998.9876
*cite journal | author=Valdez AC, Cabaniols JP, Brown MJ, Roche PA |title=Syntaxin 11 is associated with SNAP-23 on late endosomes and the trans-Golgi network. |journal=J. Cell. Sci. |volume=112 ( Pt 6) |issue= |pages= 845–54 |year= 1999 |pmid= 10036234 |doi=
*cite journal | author=Margittai M, Otto H, Jahn R |title=A stable interaction between syntaxin 1a and synaptobrevin 2 mediated by their transmembrane domains. |journal=FEBS Lett. |volume=446 |issue= 1 |pages= 40–4 |year= 1999 |pmid= 10100611 |doi=
*cite journal | author=Fasshauer D, Antonin W, Margittai M, "et al." |title=Mixed and non-cognate SNARE complexes. Characterization of assembly and biophysical properties. |journal=J. Biol. Chem. |volume=274 |issue= 22 |pages= 15440–6 |year= 1999 |pmid= 10336434 |doi=

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