Sirtuin 1

Sirtuin 1 (also known as SIRT1 or silent mating type information regulation 2 homolog S. cerevisiae) stands for [http://www.genenames.org/data/hgnc_data.php?hgnc_id=14929 sirtuin (silent mating type information regulation 2 homolog) 1 ("S. cerevisiae")] , referring to the fact that its sirtuin homolog (biological equivalent across species) in yeast "(S. cerevisiae)" is Sir2. SIRT1 is an enzyme which deacetylates proteins that contribute to cellular regulation (reaction to stressors, longevity) [http://www.sciam.com/article.cfm?articleID=000B73EB-3380-13F6-B38083414B7F0000&pageNumber=3&catID=2] .cite web | title = Entrez Gene: SIRT1 sirtuin (silent mating type information regulation 2 homolog) 1 (S. cerevisiae)| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=23411| accessdate = ]

PBB_Summary
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summary_text = This gene encodes a member of the sirtuin family of proteins, homologs to the yeast Sir2 protein. Members of the sirtuin family are characterized by a sirtuin core domain and grouped into four classes. The functions of human sirtuins have not yet been determined; however, yeast sirtuin proteins are known to regulate epigenetic gene silencing and suppress recombination of rDNA. Studies suggest that the human sirtuins may function as intracellular regulatory proteins with mono-ADP-ribosyltransferase activity. The protein encoded by this gene is included in class I of the sirtuin family.cite web | title = Entrez Gene: SIRT1 sirtuin (silent mating type information regulation 2 homolog) 1 (S. cerevisiae)| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=23411| accessdate = ]

References

Further reading

PBB_Further_reading
citations =
*cite journal | author=Frye RA |title=Characterization of five human cDNAs with homology to the yeast SIR2 gene: Sir2-like proteins (sirtuins) metabolize NAD and may have protein ADP-ribosyltransferase activity. |journal=Biochem. Biophys. Res. Commun. |volume=260 |issue= 1 |pages= 273–9 |year= 1999 |pmid= 10381378 |doi= 10.1006/bbrc.1999.0897
*cite journal | author=Frye RA |title=Phylogenetic classification of prokaryotic and eukaryotic Sir2-like proteins. |journal=Biochem. Biophys. Res. Commun. |volume=273 |issue= 2 |pages= 793–8 |year= 2000 |pmid= 10873683 |doi= 10.1006/bbrc.2000.3000
*cite journal | author=Wiemann S, Weil B, Wellenreuther R, "et al." |title=Toward a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs. |journal=Genome Res. |volume=11 |issue= 3 |pages= 422–35 |year= 2001 |pmid= 11230166 |doi= 10.1101/gr.154701
*cite journal | author=Luo J, Nikolaev AY, Imai S, "et al." |title=Negative control of p53 by Sir2alpha promotes cell survival under stress. |journal=Cell |volume=107 |issue= 2 |pages= 137–48 |year= 2001 |pmid= 11672522 |doi=
*cite journal | author=Vaziri H, Dessain SK, Ng Eaton E, "et al." |title=hSIR2(SIRT1) functions as an NAD-dependent p53 deacetylase. |journal=Cell |volume=107 |issue= 2 |pages= 149–59 |year= 2001 |pmid= 11672523 |doi=
*cite journal | author=Langley E, Pearson M, Faretta M, "et al." |title=Human SIR2 deacetylates p53 and antagonizes PML/p53-induced cellular senescence. |journal=EMBO J. |volume=21 |issue= 10 |pages= 2383–96 |year= 2002 |pmid= 12006491 |doi= 10.1093/emboj/21.10.2383
*cite journal | author=Bitterman KJ, Anderson RM, Cohen HY, "et al." |title=Inhibition of silencing and accelerated aging by nicotinamide, a putative negative regulator of yeast sir2 and human SIRT1. |journal=J. Biol. Chem. |volume=277 |issue= 47 |pages= 45099–107 |year= 2003 |pmid= 12297502 |doi= 10.1074/jbc.M205670200
*cite journal | author=Travers H, Spotswood HT, Moss PA, Turner BM |title=Human CD34+ hematopoietic progenitor cells hyperacetylate core histones in response to sodium butyrate, but not trichostatin A. |journal=Exp. Cell Res. |volume=280 |issue= 2 |pages= 149–58 |year= 2002 |pmid= 12413881 |doi=
*cite journal | author=Strausberg RL, Feingold EA, Grouse LH, "et al." |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899
*cite journal | author=Takata T, Ishikawa F |title=Human Sir2-related protein SIRT1 associates with the bHLH repressors HES1 and HEY2 and is involved in HES1- and HEY2-mediated transcriptional repression. |journal=Biochem. Biophys. Res. Commun. |volume=301 |issue= 1 |pages= 250–7 |year= 2003 |pmid= 12535671 |doi=
*cite journal | author=Senawong T, Peterson VJ, Avram D, "et al." |title=Involvement of the histone deacetylase SIRT1 in chicken ovalbumin upstream promoter transcription factor (COUP-TF)-interacting protein 2-mediated transcriptional repression. |journal=J. Biol. Chem. |volume=278 |issue= 44 |pages= 43041–50 |year= 2003 |pmid= 12930829 |doi= 10.1074/jbc.M307477200
*cite journal | author=Howitz KT, Bitterman KJ, Cohen HY, "et al." |title=Small molecule activators of sirtuins extend Saccharomyces cerevisiae lifespan. |journal=Nature |volume=425 |issue= 6954 |pages= 191–6 |year= 2003 |pmid= 12939617 |doi= 10.1038/nature01960
*cite journal | author=Ota T, Suzuki Y, Nishikawa T, "et al." |title=Complete sequencing and characterization of 21,243 full-length human cDNAs. |journal=Nat. Genet. |volume=36 |issue= 1 |pages= 40–5 |year= 2004 |pmid= 14702039 |doi= 10.1038/ng1285
*cite journal | author=Brunet A, Sweeney LB, Sturgill JF, "et al." |title=Stress-dependent regulation of FOXO transcription factors by the SIRT1 deacetylase. |journal=Science |volume=303 |issue= 5666 |pages= 2011–5 |year= 2004 |pmid= 14976264 |doi= 10.1126/science.1094637
*cite journal | author=Motta MC, Divecha N, Lemieux M, "et al." |title=Mammalian SIRT1 represses forkhead transcription factors. |journal=Cell |volume=116 |issue= 4 |pages= 551–63 |year= 2004 |pmid= 14980222 |doi=
*cite journal | author=van der Horst A, Tertoolen LG, de Vries-Smits LM, "et al." |title=FOXO4 is acetylated upon peroxide stress and deacetylated by the longevity protein hSir2(SIRT1). |journal=J. Biol. Chem. |volume=279 |issue= 28 |pages= 28873–9 |year= 2004 |pmid= 15126506 |doi= 10.1074/jbc.M401138200
*cite journal | author=Yeung F, Hoberg JE, Ramsey CS, "et al." |title=Modulation of NF-kappaB-dependent transcription and cell survival by the SIRT1 deacetylase. |journal=EMBO J. |volume=23 |issue= 12 |pages= 2369–80 |year= 2004 |pmid= 15152190 |doi= 10.1038/sj.emboj.7600244
*cite journal | author=Deloukas P, Earthrowl ME, Grafham DV, "et al." |title=The DNA sequence and comparative analysis of human chromosome 10. |journal=Nature |volume=429 |issue= 6990 |pages= 375–81 |year= 2004 |pmid= 15164054 |doi= 10.1038/nature02462
*cite journal | author=Picard F, Kurtev M, Chung N, "et al." |title=Sirt1 promotes fat mobilization in white adipocytes by repressing PPAR-gamma. |journal=Nature |volume=429 |issue= 6993 |pages= 771–6 |year= 2004 |pmid= 15175761 |doi= 10.1038/nature02583
*cite journal | author=Cohen HY, Miller C, Bitterman KJ, "et al." |title=Calorie restriction promotes mammalian cell survival by inducing the SIRT1 deacetylase. |journal=Science |volume=305 |issue= 5682 |pages= 390–2 |year= 2004 |pmid= 15205477 |doi= 10.1126/science.1099196

See also

* Sir2
* Sirtuin

External links

* [http://www.corante.com/pipeline/archives/2005/11/20/sir2_surprise.php Corante weblog by Derek Lowe] about sir2 and SIRT1 research.

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