Ewing sarcoma breakpoint region 1


Ewing sarcoma breakpoint region 1

Ewing sarcoma breakpoint region 1, also known as EWSR1, is a human gene.cite web | title = Entrez Gene: EWSR1 Ewing sarcoma breakpoint region 1| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=2130| accessdate = ]

PBB_Summary
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summary_text = This gene encodes a putative RNA binding protein. Mutations in this gene, specifically a t(11;22)(q24;q12) translocation, are known to cause Ewing sarcoma and other members of the Ewing family of tumors. Alternative splicing of this gene results in two products.cite web | title = Entrez Gene: EWSR1 Ewing sarcoma breakpoint region 1| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=2130| accessdate = ]

References

Further reading

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*PBB_Further_reading
citations =
*cite journal | author=Ban J, Siligan C, Kreppel M, "et al." |title=EWS-FLI1 in Ewing's sarcoma: real targets and collateral damage. |journal=Adv. Exp. Med. Biol. |volume=587 |issue= |pages= 41–52 |year= 2007 |pmid= 17163154 |doi=
*cite journal | author=Meister HP |title= [Morphological findings of chronic constipation in childhood] |journal=Monatsschrift für Kinderheilkunde |volume=124 |issue= 5 |pages= 354–6 |year= 1976 |pmid= 934118 |doi=
*cite journal | author=Guthrie GM, Verstraete A, Deines MM, Stern RM |title=Symptoms of stress in four societies. |journal=The Journal of social psychology |volume=95 |issue= Second half |pages= 165–72 |year= 1975 |pmid= 1127890 |doi=
*cite journal | author=Delattre O, Zucman J, Plougastel B, "et al." |title=Gene fusion with an ETS DNA-binding domain caused by chromosome translocation in human tumours. |journal=Nature |volume=359 |issue= 6391 |pages= 162–5 |year= 1992 |pmid= 1522903 |doi= 10.1038/359162a0
*cite journal | author=Bhagirath T, Abe S, Nojima T, Yoshida MC |title=Molecular analysis of a t(11;22) translocation junction in a case of Ewing's sarcoma. |journal=Genes Chromosomes Cancer |volume=13 |issue= 2 |pages= 126–32 |year= 1995 |pmid= 7542907 |doi=
*cite journal | author=Ohno T, Ouchida M, Lee L, "et al." |title=The EWS gene, involved in Ewing family of tumors, malignant melanoma of soft parts and desmoplastic small round cell tumors, codes for an RNA binding protein with novel regulatory domains. |journal=Oncogene |volume=9 |issue= 10 |pages= 3087–97 |year= 1994 |pmid= 8084618 |doi=
*cite journal | author=Maruyama K, Sugano S |title=Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides. |journal=Gene |volume=138 |issue= 1-2 |pages= 171–4 |year= 1994 |pmid= 8125298 |doi=
*cite journal | author=Plougastel B, Zucman J, Peter M, "et al." |title=Genomic structure of the EWS gene and its relationship to EWSR1, a site of tumor-associated chromosome translocation. |journal=Genomics |volume=18 |issue= 3 |pages= 609–15 |year= 1994 |pmid= 8307570 |doi=
*cite journal | author=Zucman J, Delattre O, Desmaze C, "et al." |title=EWS and ATF-1 gene fusion induced by t(12;22) translocation in malignant melanoma of soft parts. |journal=Nat. Genet. |volume=4 |issue= 4 |pages= 341–5 |year= 1993 |pmid= 8401579 |doi= 10.1038/ng0893-341
*cite journal | author=Brodie SG, Stocker SJ, Wardlaw JC, "et al." |title=EWS and WT-1 gene fusion in desmoplastic small round cell tumor of the abdomen. |journal=Hum. Pathol. |volume=26 |issue= 12 |pages= 1370–4 |year= 1996 |pmid= 8522311 |doi=
*cite journal | author=Fujimura Y, Ohno T, Siddique H, "et al." |title=The EWS-ATF-1 gene involved in malignant melanoma of soft parts with t(12;22) chromosome translocation, encodes a constitutive transcriptional activator. |journal=Oncogene |volume=12 |issue= 1 |pages= 159–67 |year= 1996 |pmid= 8552387 |doi=
*cite journal | author=Clark J, Benjamin H, Gill S, "et al." |title=Fusion of the EWS gene to CHN, a member of the steroid/thyroid receptor gene superfamily, in a human myxoid chondrosarcoma. |journal=Oncogene |volume=12 |issue= 2 |pages= 229–35 |year= 1996 |pmid= 8570200 |doi=
*cite journal | author=Magnaghi-Jaulin L, Masutani H, Robin P, "et al." |title=SRE elements are binding sites for the fusion protein EWS-FLI-1. |journal=Nucleic Acids Res. |volume=24 |issue= 6 |pages= 1052–8 |year= 1996 |pmid= 8604338 |doi=
*cite journal | author=Bonaldo MF, Lennon G, Soares MB |title=Normalization and subtraction: two approaches to facilitate gene discovery. |journal=Genome Res. |volume=6 |issue= 9 |pages= 791–806 |year= 1997 |pmid= 8889548 |doi=
*cite journal | author=Aman P, Panagopoulos I, Lassen C, "et al." |title=Expression patterns of the human sarcoma-associated genes FUS and EWS and the genomic structure of FUS. |journal=Genomics |volume=37 |issue= 1 |pages= 1–8 |year= 1997 |pmid= 8921363 |doi= 10.1006/geno.1996.0513
*cite journal | author=Morohoshi F, Arai K, Takahashi EI, "et al." |title=Cloning and mapping of a human RBP56 gene encoding a putative RNA binding protein similar to FUS/TLS and EWS proteins. |journal=Genomics |volume=38 |issue= 1 |pages= 51–7 |year= 1997 |pmid= 8954779 |doi= 10.1006/geno.1996.0591
*cite journal | author=Zucman-Rossi J, Legoix P, Thomas G |title=Identification of new members of the Gas2 and Ras families in the 22q12 chromosome region. |journal=Genomics |volume=38 |issue= 3 |pages= 247–54 |year= 1997 |pmid= 8975699 |doi= 10.1006/geno.1996.0625
*cite journal | author=Guinamard R, Fougereau M, Seckinger P |title=The SH3 domain of Bruton's tyrosine kinase interacts with Vav, Sam68 and EWS. |journal=Scand. J. Immunol. |volume=45 |issue= 6 |pages= 587–95 |year= 1997 |pmid= 9201297 |doi=
*cite journal | author=Deloulme JC, Prichard L, Delattre O, Storm DR |title=The prooncoprotein EWS binds calmodulin and is phosphorylated by protein kinase C through an IQ domain. |journal=J. Biol. Chem. |volume=272 |issue= 43 |pages= 27369–77 |year= 1997 |pmid= 9341188 |doi=
*cite journal | author=Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, "et al." |title=Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library. |journal=Gene |volume=200 |issue= 1-2 |pages= 149–56 |year= 1997 |pmid= 9373149 |doi=

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