Saposin

Saposins are small lysosomal proteins that serve as activators of various lysosomal lipid-degrading enzymescite journal |author=Munford RS, Sheppard PO, O Hara PJ |title=Saposin-like proteins (SAPLIP) carry out diverse functions on a common backbone structure |journal=J. Lipid Res. |volume=36 |issue=8 |pages=1653–1663 |year=1995 |pmid=7595087] . They probably act by isolating the lipid substrate from the membrane surroundings, thus making it more accessible to the soluble degradative enzymes. All mammalian saposins are synthesized as a single precursor molecule (prosaposin) which contains four "Saposin-B domains", yielding the active saposins after proteolytic cleavage, and two "Saposin-A domains" that are removed in the activation reaction. The Saposin-B domains also occur in other proteins, many of them active in the lysis of membranescite journal |author=Ponting CP |title=Acid sphingomyelinase possesses a domain homologous to its activator proteins: saposins B and D |journal=Protein Sci. |volume=3 |issue=2 |pages=359–361 |year=1994 |pmid=8003971] cite journal |author=Hofmann K, Tschopp J |title=Cytotoxic T cells: more weapons for new targets? |journal=Trends Microbiol. |volume=4 |issue=3 |pages=91–94 |year=1996 |pmid=8868085 |doi=10.1016/0966-842X(96)81522-8] .

Human proteins containing this domain

AOAH; GNLY; Prosaposin; PSAPL1; SFTPB;

References

Further reading

*Swaposins: circular permutations within genes encoding saposin homologues. Ponting CP, Russell RB; Trends Biochem Sci 1995;20: 179-180. PMID|7610480

External links

* [http://www.expasy.org/cgi-bin/nicedoc.pl?PDOC50015 Saposin B-type domain] in PROSITE

Wikimedia Foundation. 2010.

Игры ⚽ Нужна курсовая?

Look at other dictionaries:

Saposin protein domain — Identifiers Symbol SapA Pfam PF02199 InterPro IPR003119 … Wikipedia
saposin — sap·o·sin (SAP) (sapґə sin) any of four homologous glycoproteins, designated A through D, cleaved from the precursor prosaposin and belonging to the group of sphingolipid activator proteins; each stimulates lysosomal hydrolysis of specific… … Medical dictionary
Prosaposin — PDB rendering based on 1m12 … Wikipedia
Lysosomale Speicherkrankheit — Lysosomale Speicherkrankheiten (LSK) sind eine Gruppe von etwa 45 genetisch bedingten Stoffwechselerkrankungen, die durch Fehlfunktionen im Lysosom ausgelöst werden. Die Erkrankungen sind monogenetisch.[1] In der angelsächsischen Fachliteratur… … Deutsch Wikipedia
Lysosomale Speicherkrankheiten — (LSK) sind eine Gruppe von etwa 45 genetisch bedingten Stoffwechselerkrankungen, die durch Fehlfunktionen im Lysosom ausgelöst werden. Die Erkrankungen sind monogenetisch.[1] In der angelsächsischen Fachliteratur wird meist der Begriff Lysosomal… … Deutsch Wikipedia
metachromatic leukodystrophy — n a hereditary neurological disorder of lipid metabolism characterized by the accumulation of cerebroside sulfates, loss of myelin in the central nervous system, and progressive deterioration of mental and motor activity * * * an autosomal… … Medical dictionary
GNLY — Granulysin, also known as GNLY, is a human gene.cite web | title = Entrez Gene: GNLY granulysin| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene Cmd=ShowDetailView TermToSearch=10578| accessdate = ] PBB Summary section title = summary text … Wikipedia
AOAH — Acyloxyacyl hydrolase (neutrophil), also known as AOAH, is a human gene.cite web | title = Entrez Gene: AOAH acyloxyacyl hydrolase (neutrophil)| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene Cmd=ShowDetailView TermToSearch=313|… … Wikipedia
Antigenpräsentation — Schema der Antigenpräsentation 1 Antigen 2 Antigen präsentierende Zelle 3 Antigen MHC II Komplex 4 T Helfer Zelle 5 gebundenes Antigen 6 B… … Deutsch Wikipedia
Glucocerebrosidase — Bändermodell des GBA Tetramer, nach PDB … Deutsch Wikipedia

Academic Dictionaries and Encyclopedias

Saposin

Look at other dictionaries:

Share the article and excerpts

Academic Dictionaries and Encyclopedias

Wikipedia

Saposin

Look at other dictionaries:

Share the article and excerpts

Direct link