Ion channel family

Ion channel family

Pfam_box
Symbol = Ion_trans
Name = Ion channel (eukariotic)


width =250
caption =Potassium channel KvAP, structure in a membrane-like environment. Calculated hydrocarbon boundaries of the lipid bilayer are indicated by red and blue dots.
Pfam= PF00520
InterPro= IPR005821
SMART=
Prosite =
SCOP = 1bl8
TCDB = 1.A.1
OPM family= 8
OPM protein= 2a79
PDB=PDB3|1qg9A:157-176 PDB3|2a79B:225-409 PDB3|1ho7A:378-397PDB3|1ho2A:378-397 PDB3|1ujlA:570-611

Pfam_box
Symbol = Ion_trans_2
Name = Ion channel (bacterial)


width =200
caption =Potassium channel KcsA. Calculated hydrocarbon boundaries of the lipid bilayer are indicated by red and blue dots.
Pfam= PF07885
InterPro= IPR013099
SMART=
Prosite =
SCOP = 1bl8
TCDB =
OPM family=
OPM protein= 1r3j
PDB=PDB3|1lnqE:25-100 PDB3|2a0lB:169-250 PDB3|1orqC:169-250PDB3|1k4cC:34-116 PDB3|1r3iC:34-116 PDB3|2bocC:34-116PDB3|1j95C:34-116 PDB3|1r3lC:34-116 PDB3|1jvmB:34-116PDB3|1bl8C:34-116 PDB3|2a9hD:34-116 PDB3|1k4dC:34-116PDB3|1r3jC:34-116 PDB3|1r3kC:34-116 PDB3|2bobC:34-116PDB3|1p7bB:77-151

Transmembrane ion channel family was defined in InterPro and Pfam as the family of tetrameric sodium, potassium, and calcium ion channels, in which two C-terminal transmembrane helices flank a loop which determines ion selectivity of the channel pore. This large group of ion channels apparently includes families TCDB|1.A.1, TCDB|1.A.2, TCDB|1.A.3, and TCDB|1.A.4 of transporter classification.

Many eukariotic channels have four additional transmembrane helices (TMH) (Pfam|PF00520), whereas a bacterial structure of the protein has only two transmembrane helices that form the tetrameric channel (Pfam|PF07885).

Human channels with 6 TM helices

*CACNA1A; CACNA1B; CACNA1C; CACNA1D; CACNA1E; CACNA1F; CACNA1G; CACNA1H; CACNA1I; CACNA1S; CATSPER1; CATSPER2; CATSPER3; CATSPER4;
*CNGA1; CNGA2; CNGA3; CNGB1; CNGB3;
*H1B;
*HCN1; HCN2; HCN3; HCN4; HVCN1;
*ITPR1; ITPR2; ITPR3;
*KCNA1; KCNA10; KCNA2; KCNA3; KCNA4; KCNA5; KCNA6; KCNA7; KCNB1; KCNB2; KCNC1; KCNC2; KCNC3; KCNC4; KCND1; KCND2; KCND3; KCNF1; KCNG1; KCNG2; KCNG3; KCNG4;
*KCNH1; KCNH2; KCNH3; KCNH4; KCNH5; KCNH6; KCNH7; KCNH8; KCNMA1;
*KCNQ1; KCNQ2; KCNQ3; KCNQ4; KCNQ5; KCNS1; KCNS2; KCNS3; KCNV1; KCNV2;
*MCOLN1; MCOLN2;MCOLN3; MLSN1; NALCN;
*PKD1L3;
*RCNC2; RYR1; RYR2; RYR3;
*SCN10A; SCN11A; SCN1A; SCN2A; SCN2A2; SCN3A; SCN4A; SCN5A; SCN7A; SCN8A; SCN9A;
*SLC9A10; SLC9A11;
*TPCN1; TPCN2; TRP7; TRPA1; TRPC1; TRPC3; TRPC4; TRPC5; TRPC6; TRPC7;
*TRPM1; TRPM2; TRPM3; TRPM4; TRPM5; TRPM6; TRPM7; TRPM8;
*TRPV1; TRPV2; TRPV3; TRPV4; TRPV5; TRPV6; VGCNL1;

Human channels with two TM helices in each subunit, as in bacteria

*KCNK1; KCNK10; KCNK12; KCNK13; KCNK15; KCNK16; KCNK17; KCNK18; KCNK2; KCNK3; KCNK4; KCNK5; KCNK6; KCNK7; KCNK9; KCNN1; KCNN2; KCNN3; KCNN4;
*KCNT1; KCNT2;
*SK2; SK3; SLICK;

References

* [1] . Potassium channel structures. Choe S; Nat Rev Neurosci 2002;3:115-121. PMID|11836519


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