Phosphomethylpyrimidine kinase

Phosphomethylpyrimidine kinase

In enzymology, a phosphomethylpyrimidine kinase (EC number| is an enzyme that catalyzes the chemical reaction

:ATP + (4-amino-2-methylpyrimidin-5-yl)methyl phosphate ightleftharpoons ADP + (4-amino-2-methylpyrimidin-5-yl)methyl diphosphate

Thus, the two substrates of this enzyme are ATP and (4-amino-2-methylpyrimidin-5-yl)methyl phosphate, whereas its two products are ADP and (4-amino-2-methylpyrimidin-5-yl)methyl diphosphate.

This enzyme belongs to the family of transferases, specifically those transferring phosphorus-containing groups (phosphotransferases) with a phosphate group as acceptor. The systematic name of this enzyme class is ATP:(4-amino-2-methylpyrimidin-5-yl)methyl-phosphate phosphotransferase. Other names in common use include hydroxymethylpyrimidine phosphokinase, and ATP:4-amino-2-methyl-5-phosphomethylpyrimidine phosphotransferase. This enzyme participates in thiamine metabolism.

tructural studies

As of late 2007, 4 structures have been solved for this class of enzymes, with PDB accession codes PDB link|1JXH, PDB link|1JXI, PDB link|1UB0, and PDB link|2I5B.



External links

::"The CAS registry number for this enzyme class is CAS registry|37278-18-5."

Gene Ontology (GO) codes

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Look at other dictionaries:

  • List of EC numbers (EC 2) — This list contains a list of EC numbers for the second group, EC 2, transferases, placed in numerical order as determined by the Nomenclature Committee of the International Union of Biochemistry and Molecular Biology.EC 2.1: Transferring One… …   Wikipedia