MRNA guanylyltransferase


MRNA guanylyltransferase

In enzymology, a mRNA guanylyltransferase (EC number|2.7.7.50) is an enzyme that catalyzes the chemical reaction

:GTP + (5')ppPur-mRNA ightleftharpoons diphosphate + G(5')pppPur-mRNA

Thus, the two substrates of this enzyme are GTP and (5')ppPur-mRNA, whereas its two products are diphosphate and G(5')pppPur-mRNA.

This enzyme belongs to the family of transferases, specifically those transferring phosphorus-containing nucleotide groups (nucleotidyltransferases). The systematic name of this enzyme class is GTP:mRNA guanylyltransferase. Other names in common use include mRNA capping enzyme, messenger RNA guanylyltransferase, and Protein 2.

tructural studies

As of late 2007, 5 structures have been solved for this class of enzymes, with PDB accession codes PDB link|1CKM, PDB link|1CKN, PDB link|1CKO, PDB link|1P16, and PDB link|2C46.

References

*
*
*
*
*

External links

::"The CAS registry number for this enzyme class is CAS registry|56941-23-2."

Gene Ontology (GO) codes


Wikimedia Foundation. 2010.

Look at other dictionaries:

  • List of EC numbers (EC 2) — This list contains a list of EC numbers for the second group, EC 2, transferases, placed in numerical order as determined by the Nomenclature Committee of the International Union of Biochemistry and Molecular Biology.EC 2.1: Transferring One… …   Wikipedia

  • RNGTT — RNA guanylyltransferase and 5 phosphatase, also known as RNGTT, is a human gene.cite web | title = Entrez Gene: RNGTT RNA guanylyltransferase and 5 phosphatase| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene Cmd=ShowDetailView… …   Wikipedia

  • Coiffe (biologie) — Pour les articles homonymes, voir Coiffe. Structure de la coiffe en 5 des ARN transcrits par l ARN polymérase II La coiffe ou 5 cap est un nucléotide modifié que l on trouve à l ext …   Wikipédia en Français

  • Rotavirus — Taxobox name = Rotavirus status = status ref = image width = 180px image caption = Electron micrograph of Rotaviruses. The bar = 100 nm image2 width = image2 caption = virus group = iii familia = Reoviridae genus = Rotavirus species = A, B, C, D …   Wikipedia

  • RNA polymerase — RNAP from T. aquaticus pictured during elongation. Portions of the enzyme were made transparent so as to make the path of RNA and DNA more clear. The magnesium ion (yellow) is located at the enzyme active site. RNA polymerase (RNAP or RNApol) is… …   Wikipedia

  • Mevalonate kinase — Crystallographic structure of mevalonate kinase from Staphylococcus aureus.[1] Identifiers …   Wikipedia

  • Glucokinase — (hexokinase 4) Based on PDB entry 1GLK …   Wikipedia

  • Guanylyl transferase — enzymes transfer one molecule of guanosine triphosphate (GTP) to another molecule, releasing pyrophosphate. Many eukaryotic guanylyl transferases are capping enzymes that catalyze the formation of the 5 cap in the post transcriptional… …   Wikipedia

  • Terminal deoxynucleotidyl transferase — Deoxynucleotidyltransferase, terminal Amino acids 19 125 of human DNA nucleotidylexotransferase. PDB rendering based on 2coe …   Wikipedia

  • Deoxycytidine kinase — PDB rendering based on 1p5z …   Wikipedia


Share the article and excerpts

Direct link
Do a right-click on the link above
and select “Copy Link”

We are using cookies for the best presentation of our site. Continuing to use this site, you agree with this.