Mannose-1-phosphate guanylyltransferase

mannose-1-phosphate guanylyltransferase
Identifiers
EC number	2.7.7.13
CAS number	37278-24-3
Databases
IntEnz	IntEnz view
BRENDA	BRENDA entry
ExPASy	NiceZyme view
KEGG	KEGG entry
MetaCyc	metabolic pathway
PRIAM	profile
PDB structures	RCSB PDB PDBe PDBsum
Gene Ontology	AmiGO / EGO
Search PMC articles PubMed articles

In enzymology, a mannose-1-phosphate guanylyltransferase (EC 2.7.7.13) is an enzyme that catalyzes the chemical reaction

GTP + alpha-D-mannose 1-phosphate $\rightleftharpoons$ diphosphate + GDP-mannose

Thus, the two substrates of this enzyme are GTP and alpha-D-mannose 1-phosphate, whereas its two products are diphosphate and GDP-mannose.

This enzyme belongs to the family of transferases, specifically those transferring phosphorus-containing nucleotide groups (nucleotidyltransferases). The systematic name of this enzyme class is GTP:alpha-D-mannose-1-phosphate guanylyltransferase. Other names in common use include GTP-mannose-1-phosphate guanylyltransferase, PIM-GMP (phosphomannose isomerase-guanosine 5'-diphospho-D-mannose, pyrophosphorylase), GDP-mannose pyrophosphorylase, guanosine 5'-diphospho-D-mannose pyrophosphorylase, guanosine diphosphomannose pyrophosphorylase, guanosine triphosphate-mannose 1-phosphate guanylyltransferase, and mannose 1-phosphate guanylyltransferase (guanosine triphosphate). This enzyme participates in fructose and mannose metabolism.

Structural studies

As of late 2007, only one structure has been solved for this class of enzymes, with the PDB accession code 2CU2.

References

• Munch-Peterson A (1955). "Enzymatic synthesis and phosphorolysis of guanosine diphosphate mannose". Arch. Biochem. Biophys. 55 (2): 592–593. doi:10.1016/0003-9861(55)90441-0. 
• PREISS J, WOOD E (1964). "SUGAR NUCLEOTIDE REACTIONS IN ARTHROBACTER. I. GUANOSINE DIPHOSPHATE MANNOSE PYROPHOSPHORYLASE: PURIFICATION AND PROPERTIES". J. Biol. Chem. 239: 3119–26. PMID 14245350. 

This enzyme-related article is a stub. You can help Wikipedia by expanding it.v · Categories: Enzyme stubs EC 2.7.7 Enzymes of known structure Wikimedia Foundation. 2010. Игры ⚽ Поможем сделать НИР Pakistani films of 1997 Knave of Hearts (Alice's Adventures in Wonderland) Look at other dictionaries: Mannose-1-phosphate guanylyltransferase (GDP) — Identifiers EC number 2.7.7.22 CAS number 9026 31 7 …   Wikipedia mannose-1-phosphate guanylyltransferase — A transferase that catalyzes the reaction of GTP and mannose 1 phosphate to produce GDPmannose and pyrophosphate. SYN: GDPmannose phosphorylase …   Medical dictionary mannose-1-phosphate guanylyltransferase (GDP) — man·nose 1 phos·phate gua·nyl·yl·trans·fer·ase (GDP) (manґōs fosґfāt gwah″nəl əl transґfər ās) [EC 2.7.7.22] an enzyme of the transferase class that catalyzes the synthesis of GDP mannose from GDP and mannose 1 …   Medical dictionary Fucose-1-phosphate guanylyltransferase — In enzymology, a fucose 1 phosphate guanylyltransferase (EC number|2.7.7.30) is an enzyme that catalyzes the chemical reaction:GTP + beta L fucose 1 phosphate ightleftharpoons diphosphate + GDP L fucoseThus, the two substrates of this enzyme are… …   Wikipedia List of EC numbers (EC 2) — This list contains a list of EC numbers for the second group, EC 2, transferases, placed in numerical order as determined by the Nomenclature Committee of the International Union of Biochemistry and Molecular Biology.EC 2.1: Transferring One… …   Wikipedia Colitose — IUPAC name (2S,4S,5S) 2,4,5 trihydroxyhexanal Identif …   Wikipedia GDPmannose phosphorylase — SYN: mannose 1 phosphate guanylyltransferase (GDP) …   Medical dictionary FPGT — Fucose 1 phosphate guanylyltransferase, also known as FPGT, is a human gene.cite web | title = Entrez Gene: FPGT fucose 1 phosphate guanylyltransferase| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene Cmd=ShowDetailView TermToSearch=8790|… …   Wikipedia Glucokinase — (hexokinase 4) Based on PDB entry 1GLK …   Wikipedia Guanylyl transferase — enzymes transfer one molecule of guanosine triphosphate (GTP) to another molecule, releasing pyrophosphate. Many eukaryotic guanylyl transferases are capping enzymes that catalyze the formation of the 5 cap in the post transcriptional… …   Wikipedia 18+ © Academic, 2000-2024 Contact us: Technical Support, Advertising Dictionaries export, created on PHP, Joomla, Drupal, WordPress, MODx. Mark and share Search through all dictionaries Translate… Search Internet Share the article and excerpts Direct link … Do a right-click on the link above and select “Copy Link”