Diacylglycerol cholinephosphotransferase

Diacylglycerol cholinephosphotransferase
diacylglycerol cholinephosphotransferase
Identifiers
EC number 2.7.8.2
CAS number 9026-13-5
Databases
IntEnz IntEnz view
BRENDA BRENDA entry
ExPASy NiceZyme view
KEGG KEGG entry
MetaCyc metabolic pathway
PRIAM profile
PDB structures RCSB PDB PDBe PDBsum
Gene Ontology AmiGO / EGO

In enzymology, a diacylglycerol cholinephosphotransferase (EC 2.7.8.2) is an enzyme that catalyzes the chemical reaction

CDP-choline + 1,2-diacylglycerol \rightleftharpoons CMP + a phosphatidylcholine

Thus, the two substrates of this enzyme are CDP-choline and 1,2-diacylglycerol, whereas its two products are CMP and phosphatidylcholine.

This enzyme belongs to the family of transferases, specifically those transferring non-standard substituted phosphate groups. The systematic name of this enzyme class is CDP choline:1,2-diacylglycerol cholinephosphotransferase. Other names in common use include phosphorylcholine-glyceride transferase, alkylacylglycerol cholinephosphotransferase, 1-alkyl-2-acetylglycerol cholinephosphotransferase, cholinephosphotransferase, CPT, alkylacylglycerol choline phosphotransferase, diacylglycerol choline phosphotransferase, 1-alkyl-2-acetyl-m-glycerol:CDPcholine choline phosphotransferase, CDP-choline diglyceride phosphotransferase, cytidine diphosphocholine glyceride transferase, cytidine diphosphorylcholine diglyceride transferase, phosphocholine diacylglyceroltransferase, sn-1,2-diacylglycerol cholinephosphotransferase, and 1-alkyl-2-acetyl-sn-glycerol cholinephosphotransferase. This enzyme participates in 3 metabolic pathways: aminophosphonate metabolism, glycerophospholipid metabolism, and ether lipid metabolism.

References

  • Coleman R, Bell RM (1977). "Phospholipid synthesis in isolated fat cells. Studies of microsomal diacylglycerol cholinephosphotransferase and diacylglycerol ethanolaminephosphotransferase activities". J. Biol. Chem. 252 (9): 3050–6. PMID 192727. 
  • Lee TC, Blank ML, Fitzgerald V, Snyder F (1982). "Formation of alkylacyl- and diacylglycerophosphocholines via diradylglycerol cholinephosphotransferase in rat liver". Biochim. Biophys. Acta. 713 (2): 479–83. PMID 6295501. 
  • Parthasarathy S, Cady RK, Kraushaar DS, Sladek NE, Baumann WJ (1978). "Inhibition of diacylglycerol:CDPcholine cholinephosphotransferase activity by dimethylaminoethyl p-chlorophenoxyacetate". Lipids. 13 (2): 161–4. doi:10.1007/BF02533260. PMID 204847. 
  • Renooij W, Snyder F (1981). "Biosynthesis of 1-alkyl-2-acetyl-sn-glycero-3-phosphocholine (platelet activating factor and a hypotensive lipid) by cholinephosphotransferase in various rat tissues". Biochim. Biophys. Acta. 663 (2): 545–56. PMID 6260215. 
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