Deoxyguanosine kinase


Deoxyguanosine kinase
deoxyguanosine kinase
Identifiers
EC number 2.7.1.113
CAS number 39471-28-8
Databases
IntEnz IntEnz view
BRENDA BRENDA entry
ExPASy NiceZyme view
KEGG KEGG entry
MetaCyc metabolic pathway
PRIAM profile
PDB structures RCSB PDB PDBe PDBsum
Gene Ontology AmiGO / EGO

In enzymology, a deoxyguanosine kinase (EC 2.7.1.113) is an enzyme that catalyzes the chemical reaction

ATP + deoxyguanosine \rightleftharpoons ADP + dGMP

Thus, the two substrates of this enzyme are ATP and deoxyguanosine, whereas its two products are ADP and dGMP.

This enzyme belongs to the family of transferases, specifically those transferring phosphorus-containing groups (phosphotransferases) with an alcohol group as acceptor. The systematic name of this enzyme class is ATP:deoxyguanosine 5'-phosphotransferase. Other names in common use include deoxyguanosine kinase (phosphorylating), (dihydroxypropoxymethyl)guanine kinase, 2'-deoxyguanosine kinase, and NTP-deoxyguanosine 5'-phosphotransferase. This enzyme participates in purine metabolism.

Structural studies

As of late 2007, 4 structures have been solved for this class of enzymes, with PDB accession codes 2JAQ, 2JAS, 2JAT, and 2OCP.

Clinical

Mutations in this gene have been linked to inherited mitochondrial DNA depletion syndromes, neonatal liver failure, nystagmus and hypotonia.

References

  • Barker J, Lewis RA (1981). "Deoxyguanosine kinase of neonatal mouse skin tissue". Biochim. Biophys. Acta. 658 (1): 111–23. PMID 6260206. 
  • Gower WR Jr, Carr MC, Ives DH (1979). "Deoxyguanosine kinase. Distinct molecular forms in mitochondria and cytosol". J. Biol. Chem. 254 (7): 2180–3. PMID 218928.