Ceramide cholinephosphotransferase


Ceramide cholinephosphotransferase
ceramide cholinephosphotransferase
Identifiers
EC number 2.7.8.3
CAS number 9026-14-6
Databases
IntEnz IntEnz view
BRENDA BRENDA entry
ExPASy NiceZyme view
KEGG KEGG entry
MetaCyc metabolic pathway
PRIAM profile
PDB structures RCSB PDB PDBe PDBsum
Gene Ontology AmiGO / EGO

In enzymology, a ceramide cholinephosphotransferase (EC 2.7.8.3) is an enzyme that catalyzes the chemical reaction

CDP-choline + N-acylsphingosine \rightleftharpoons CMP + sphingomyelin

Thus, the two substrates of this enzyme are CDP-choline and N-acylsphingosine, whereas its two products are CMP and sphingomyelin.

This enzyme belongs to the family of transferases, specifically those transferring non-standard substituted phosphate groups. The systematic name of this enzyme class is CDP-choline:N-acylsphingosine cholinephosphotransferase. This enzyme is also called phosphorylcholine-ceramide transferase. This enzyme participates in sphingolipid metabolism.

References

  • Kennedy EP (1962). "Phosphorylcholine-glyceride transferase". Methods Enzymol. 5: 484–486. 
  • Sribney M and Kennedy EP (1958). "The enzymatic synthesis of sphingomyelin". J. Biol. Chem. 233 (6): 1315–1322. PMID 13610834.