Ceramide cholinephosphotransferase

ceramide cholinephosphotransferase
Identifiers
EC number	2.7.8.3
CAS number	9026-14-6
Databases
IntEnz	IntEnz view
BRENDA	BRENDA entry
ExPASy	NiceZyme view
KEGG	KEGG entry
MetaCyc	metabolic pathway
PRIAM	profile
PDB structures	RCSB PDB PDBe PDBsum
Gene Ontology	AmiGO / EGO
Search PMC articles PubMed articles

In enzymology, a ceramide cholinephosphotransferase (EC 2.7.8.3) is an enzyme that catalyzes the chemical reaction

CDP-choline + N-acylsphingosine $\rightleftharpoons$ CMP + sphingomyelin

Thus, the two substrates of this enzyme are CDP-choline and N-acylsphingosine, whereas its two products are CMP and sphingomyelin.

This enzyme belongs to the family of transferases, specifically those transferring non-standard substituted phosphate groups. The systematic name of this enzyme class is CDP-choline:N-acylsphingosine cholinephosphotransferase. This enzyme is also called phosphorylcholine-ceramide transferase. This enzyme participates in sphingolipid metabolism.

References

• Kennedy EP (1962). "Phosphorylcholine-glyceride transferase". Methods Enzymol. 5: 484–486. 
• Sribney M and Kennedy EP (1958). "The enzymatic synthesis of sphingomyelin". J. Biol. Chem. 233 (6): 1315–1322. PMID 13610834. 

This enzyme-related article is a stub. You can help Wikipedia by expanding it.v · Categories: Enzyme stubs EC 2.7.8 Enzymes of unknown structure Wikimedia Foundation. 2010. Игры ⚽ Нужно сделать НИР? The Squaw Man (1918 film) Luis de Cortázar Look at other dictionaries: ceramide cholinephosphotransferase — cer·a·mide cho·line·phos·pho·trans·fer·ase (serґə mīd ko″lēn fos″fo transґfər ās) [EC 2.7.8.3] an enzyme of the transferase class that catalyzes the transfer of a phosphorylated choline group from CDPcholine… …   Medical dictionary List of EC numbers (EC 2) — This list contains a list of EC numbers for the second group, EC 2, transferases, placed in numerical order as determined by the Nomenclature Committee of the International Union of Biochemistry and Molecular Biology.EC 2.1: Transferring One… …   Wikipedia Citicoline — Systematic (IUPAC) name 5 O [hydroxy({hydroxy[2 (trimethylammonio)ethoxy] phosphoryl}oxy)phosphoryl]cytidine Clinical data AHFS/ …   Wikipedia Sphingomyelin synthase — In enzymology, a sphingomyelin synthase (EC number|2.7.8.27) is an enzyme that catalyzes the chemical reaction:a ceramide + a phosphatidylcholine ightleftharpoons a sphingomyelin + a 1,2 diacyl sn glycerolThus, the two substrates of this enzyme… …   Wikipedia 18+ © Academic, 2000-2024 Contact us: Technical Support, Advertising Dictionaries export, created on PHP, Joomla, Drupal, WordPress, MODx. Mark and share Search through all dictionaries Translate… Search Internet Share the article and excerpts Direct link … Do a right-click on the link above and select “Copy Link”