Glycoside hydrolase family 1


Glycoside hydrolase family 1

Pfam_box
Symbol = Glyco_hydro_1
Name = Glycosyl hydrolase family 1


width =
caption =
Pfam= PF00232
InterPro= IPR001360
SMART=
PROSITE = PDOC00495
SCOP = 1cbg
TCDB =
OPM family= 125
OPM protein= 1vff
PDB=PDB3|4pbgB:1-467 PDB3|3pbgB:1-467 PDB3|1pbgA:1-467PDB3|2pbgA:1-467 PDB3|1cbg :26-410 PDB3|1v02D:72-551PDB3|1v03A:72-551 PDB3|1v08B:74-558 PDB3|1e1fA:74-558PDB3|1hxjB:74-558 PDB3|1e4nB:74-558 PDB3|1e55B:74-558PDB3|1e4lA:74-558 PDB3|1e1eA:74-558 PDB3|1e56B:74-558PDB3|1h49A:74-558 PDB3|1e73M:21-222 PDB3|1e72M:21-222PDB3|1e4mM:21-222 PDB3|1e6sM:21-222 PDB3|1e6qM:21-222PDB3|1e70M:21-222 PDB3|1e6xM:21-222 PDB3|1e71M:21-222PDB3|1mquA:3-435 PDB3|1uz1A:2-444 PDB3|1oinA:2-444PDB3|1oimB:2-444 PDB3|1od0A:2-444 PDB3|1oifB:2-444PDB3|1w3jB:2-444 PDB3|1ug6A:1-431 PDB3|1np2A:1-431PDB3|1gonB:14-476 PDB3|1gnxB:14-476 PDB3|1bggC:2-444PDB3|1bgaA:2-444 PDB3|1tr1C:2-444 PDB3|1e4iA:2-444PDB3|1uyqA:2-444 PDB3|1qoxL:2-448 PDB3|1wcgA:1-464PDB3|1uwsA:308-471 PDB3|1uwrA:308-471 PDB3|1uwqB:308-471PDB3|1uwiA:308-471 PDB3|1uwuA:308-471 PDB3|1gowA:308-471PDB3|1uwtA:308-471 PDB3|1qvbA:307-470 PDB3|1vffA:1-408

Glycoside hydrolase family 1 is a family of glycoside hydrolases.

O-Glycosyl hydrolases EC number|3.2.1. are a widespread group of enzymes that hydrolyse the glycosidic bond between two or more carbohydrates, or between a carbohydrate and a non-carbohydrate moiety. A classification system for glycosyl hydrolases, based on sequence similarity, has led to the definition of 85 different familiescite journal |author=Henrissat B, Callebaut I, Mornon JP, Fabrega S, Lehn P, Davies G |title=Conserved catalytic machinery and the prediction of a common fold for several families of glycosyl hydrolases |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=92 |issue=15 |pages=7090–7094 |year=1995 |pmid=7624375 |doi=10.1073/pnas.92.15.7090] cite journal |author=Henrissat B, Davies G |title=Structures and mechanisms of glycosyl hydrolases |journal=Structure |volume=3 |issue=9 |pages=853–859 |year=1995 |pmid=8535779 |doi=10.1016/S0969-2126(01)00220-9] [ [http://www.expasy.ch/cgi-bin/lists?glycosid.txt Bairoch, A. "Classification of glycosyl hydrolase families and index of glycosyl hydrolase entries in SWISS-PROT". 1999.] ] . This classification is available on the CAZy(CArbohydrate-Active EnZymes) web site [ [http://www.cazy.org/ Henrissat, B. and Coutinho P.M. "Carbohydrate-Active Enzymes server". 1999.] ] . Because the fold of proteins is better conserved than their sequences, some of the families can be grouped in 'clans'.

Glycoside hydrolase family 1 [http://www.cazy.org/fam/GH_1.html CAZY GH_1] comprises enzymes with a number of known activities; beta-glucosidase (EC number|3.2.1.21); beta-galactosidase (EC number|3.2.1.23); 6-phospho-beta-galactosidase (EC number|3.2.1.85); 6-phospho-beta-glucosidase (EC number|3.2.1.86); lactase-phlorizin hydrolase (EC number|3.2.1.62), lactase (EC number|3.2.1.108); beta-mannosidase (EC number|3.2.1.25); myrosinase (EC number|3.2.1.147).

ubfamilies

*6-phospho-beta-galactosidase InterPro|IPR005928

Human proteins containing this domain

GBA3; KL; KLB; LCT; LCTL;

ee also

[http://www.cazypedia.org/index.php/Glycoside_Hydrolase_Family_1 GH1 in CAZypedia]

References


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