- Mannotetraose 2-alpha-N-acetylglucosaminyltransferase
mannotetraose 2-alpha-N-acetylglucosaminyltransferase Identifiers EC number 126.96.36.199 CAS number 81032-47-5 Databases IntEnz IntEnz view BRENDA BRENDA entry ExPASy NiceZyme view KEGG KEGG entry MetaCyc metabolic pathway PRIAM profile PDB structures RCSB PDB PDBe PDBsum Gene Ontology AmiGO / EGO Search PMC articles PubMed articles
- UDP-N-acetyl-D-glucosamine + 1,3-alpha-D-mannosyl-1,2-alpha-D-mannosyl-1,2-alpha-D-mannosyl-D-mannose UDP + 1,3-alpha-D-mannosyl-1,2-(N-acetyl-alpha-D-glucosaminyl-alpha-D-mannosyl)-1,2-alpha-D-mannosyl-D-mannose
The 2 substrates of this enzyme are UDP-N-acetyl-D-glucosamine and 1,3-alpha-D-mannosyl-1,2-alpha-D-mannosyl-1,2-alpha-D-mannosyl-D-mannose, whereas its 2 products are UDP and 1,3-alpha-D-mannosyl-1,2-(N-acetyl-alpha-D-glucosaminyl-alpha-D-mannosyl)-1,2-alpha-D-mannosyl-D-mannose.
This enzyme belongs to the family of glycosyltransferases, specifically the hexosyltransferases. The systematic name of this enzyme class is UDP-N-acetyl-D-glucosamine:mannotetraose alpha-N-acetyl-D-glucosaminyltransferase. Other names in common use include alpha-N-acetylglucosaminyltransferase, uridine diphosphoacetylglucosamine mannoside, and alpha1->2-alphacetylglucosaminyltransferase.
- Douglas RH, Ballou CE (1982). "Purification of an alpha-N-acetylglucosaminyltransferase from the yeast Kluyveromyces lactis and a study of mutants defective in this enzyme activity". Biochemistry. 21 (7): 1561–70. doi:10.1021/bi00536a015. PMID 6211189.
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