Retinal G protein coupled receptor


Retinal G protein coupled receptor

Retinal G protein coupled receptor, also known as RGR, is a human gene.cite web | title = Entrez Gene: RGR retinal G protein coupled receptor| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=5995| accessdate = ]

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summary_text = Defects in this gene are a cause of retinitis pigmentosa. The gene is a member of the rhodopsin-like receptor subfamily of GPCR. Like other opsins which bind retinaldehyde, it contains a conserved lysine residue in the seventh transmembrane domain. The protein presumably acts as a photoisomerase to catalyze the conversion of all-trans-retinal to 11-cis-retinal, similar to retinochrome in invertebrates. The reverse isomerization occurs with rhodopsin in retinal photoreceptor cells. The protein is exclusively expressed in tissue adjacent to retinal photoreceptor cells, the retinal pigment epithelium and Mueller cells. This gene may be associated with autosomal recessive and autosomal dominant retinitis pigmentosa (arRP and adRP, respectively). Alternative splicing results in multiple transcript variants encoding different isoforms.cite web | title = Entrez Gene: RGR retinal G protein coupled receptor| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=5995| accessdate = ]

References

Further reading

PBB_Further_reading
citations =
*cite journal | author=Jiang M, Shen D, Tao L, "et al." |title=Alternative splicing in human retinal mRNA transcripts of an opsin-related protein. |journal=Exp. Eye Res. |volume=60 |issue= 4 |pages= 401–6 |year= 1995 |pmid= 7789419 |doi=
*cite journal | author=Shen D, Jiang M, Hao W, "et al." |title=A human opsin-related gene that encodes a retinaldehyde-binding protein. |journal=Biochemistry |volume=33 |issue= 44 |pages= 13117–25 |year= 1994 |pmid= 7947717 |doi=
*cite journal | author=Chen XN, Korenberg JR, Jiang M, "et al." |title=Localization of the human RGR opsin gene to chromosome 10q23. |journal=Hum. Genet. |volume=97 |issue= 6 |pages= 720–2 |year= 1996 |pmid= 8641686 |doi=
*cite journal | author=Morimura H, Saindelle-Ribeaudeau F, Berson EL, Dryja TP |title=Mutations in RGR, encoding a light-sensitive opsin homologue, in patients with retinitis pigmentosa. |journal=Nat. Genet. |volume=23 |issue= 4 |pages= 393–4 |year= 1999 |pmid= 10581022 |doi= 10.1038/70496
*cite journal | author=Chen P, Lee TD, Fong HK |title=Interaction of 11-cis-retinol dehydrogenase with the chromophore of retinal g protein-coupled receptor opsin. |journal=J. Biol. Chem. |volume=276 |issue= 24 |pages= 21098–104 |year= 2001 |pmid= 11274198 |doi= 10.1074/jbc.M010441200
*cite journal | author=Yang M, Fong HK |title=Synthesis of the all-trans-retinal chromophore of retinal G protein-coupled receptor opsin in cultured pigment epithelial cells. |journal=J. Biol. Chem. |volume=277 |issue= 5 |pages= 3318–24 |year= 2002 |pmid= 11723126 |doi= 10.1074/jbc.M108946200
*cite journal | author=Strausberg RL, Feingold EA, Grouse LH, "et al." |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899
*cite journal | author=Bellingham J, Wells DJ, Foster RG |title=In silico characterisation and chromosomal localisation of human RRH (peropsin)--implications for opsin evolution. |journal=BMC Genomics |volume=4 |issue= 1 |pages= 3 |year= 2003 |pmid= 12542842 |doi=
*cite journal | author=Tarttelin EE, Bellingham J, Bibb LC, "et al." |title=Expression of opsin genes early in ocular development of humans and mice. |journal=Exp. Eye Res. |volume=76 |issue= 3 |pages= 393–6 |year= 2003 |pmid= 12573668 |doi=
*cite journal | author=Bernal S, Calaf M, Garcia-Hoyos M, "et al." |title=Study of the involvement of the RGR, CRPB1, and CRB1 genes in the pathogenesis of autosomal recessive retinitis pigmentosa. |journal=J. Med. Genet. |volume=40 |issue= 7 |pages= e89 |year= 2003 |pmid= 12843338 |doi=
*cite journal | author=Gerhard DS, Wagner L, Feingold EA, "et al." |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121–7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504
*cite journal | author=Rual JF, Venkatesan K, Hao T, "et al." |title=Towards a proteome-scale map of the human protein-protein interaction network. |journal=Nature |volume=437 |issue= 7062 |pages= 1173–8 |year= 2005 |pmid= 16189514 |doi= 10.1038/nature04209
*cite journal | author=Zhu L, Imanishi Y, Filipek S, "et al." |title=Autosomal recessive retinitis pigmentosa and E150K mutation in the opsin gene. |journal=J. Biol. Chem. |volume=281 |issue= 31 |pages= 22289–98 |year= 2006 |pmid= 16737970 |doi= 10.1074/jbc.M602664200
*cite journal | author=Lin MY, Kochounian H, Moore RE, "et al." |title=Deposition of exon-skipping splice isoform of human retinal G protein-coupled receptor from retinal pigment epithelium into Bruch's membrane. |journal=Mol. Vis. |volume=13 |issue= |pages= 1203–14 |year= 2007 |pmid= 17679941 |doi=

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