Formylmethanofuran-tetrahydromethanopterin N-formyltransferase

In enzymology, a formylmethanofuran-tetrahydromethanopterin N-formyltransferase (EC number|2.3.1.101) is an enzyme that catalyzes the chemical reaction

:formylmethanofuran + 5,6,7,8-tetrahydromethanopterin $ightleftharpoons$ methanofuran + 5-formyl-5,6,7,8-tetrahydromethanopterin

Thus, the two substrates of this enzyme are formylmethanofuran and 5,6,7,8-tetrahydromethanopterin, whereas its two products are methanofuran and 5-formyl-5,6,7,8-tetrahydromethanopterin.

This enzyme belongs to the family of transferases, specifically those acyltransferases transferring groups other than aminoacyl groups. The systematic name of this enzyme class is formylmethanofuran:5,6,7,8-tetrahydromethanopterin 5-formyltransferase. Other names in common use include formylmethanofuran-tetrahydromethanopterin formyltransferase, formylmethanofuran:tetrahydromethanopterin formyltransferase, N-formylmethanofuran(CHO-MFR):tetrahydromethanopterin(H4MPT), formyltransferase, FTR, formylmethanofuran:5,6,7,8-tetrahydromethanopterin, and N5-formyltransferase. This enzyme participates in folate biosynthesis.

tructural studies

As of late 2007, 5 structures have been solved for this class of enzymes, with PDB accession codes PDB link|1FTR, PDB link|1M5H, PDB link|1M5S, PDB link|2FHJ, and PDB link|2FHK.

References

*
*

External links

::"The CAS registry number for this enzyme class is CAS registry|105669-83-8."

Gene Ontology (GO) codes