- Physiological agonism and antagonism
Physiological agonism and antagonism is the mechanism of substances to induce the same ultimate effects in the body as other substances, as if they were
receptor agonistsor antagonists, but without binding to the same receptor.
Adrenalineinduces platelet aggregationand so does hepatocyte growth factor(HGF) [ [http://www.sciencedirect.com/science?_ob=ArticleURL&_udi=B6T36-4GNKKH4-7&_user=10&_coverDate=08%2F15%2F2005&_rdoc=1&_fmt=&_orig=search&_sort=d&view=c&_acct=C000050221&_version=1&_urlVersion=0&_userid=10&md5=d2a9455c84d230d0bd247b2b0c7eb169 doi:10.1016/j.febslet.2005.06.072 Met identification on human platelets: Role of hepatocyte growth factor in the modulation of platelet activation] Copyright © 2005 Published by Elsevier B.V. Edited by Veli-Pekka Lehto. Daniela Pietrapiana, Marilena Sala, Maria Prat1 and Fabiola Sinigaglia, 1, Department of Medical Science, University “A. Avogadro”, Via Solaroli, 17, Novara 28100, Italy Received 4 May 2005; revised 15 June 2005; accepted 21 June 2005. Available online 19 July 2005. ] . Thus, they are physiological agonists to each other.
*There are several "physiological antagonists" that have
antihistaminergicaction. For instance, adrenalineraises arterial pressure through vasoconstriction mediated by β-adrenergic receptoractivation, in contrast to the histamineeffect of lowering arterial pressure. However, only such substances that bind and block the histamine receptorare true antihistamines.
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