Amidase

Amidase

In enzymology, an amidase (EC number|3.5.1.4) is an enzyme that catalyzes the chemical reaction

:a monocarboxylic acid amide + H2O ightleftharpoons a monocarboxylate + NH3

Thus, the two substrates of this enzyme are monocarboxylic acid amide and H2O, whereas its two products are monocarboxylate and NH3.

This enzyme belongs to the family of hydrolases, those acting on carbon-nitrogen bonds other than peptide bonds, specifically in linear amides. The systematic name of this enzyme class is acylamide amidohydrolase. Other names in common use include acylamidase, acylase, amidohydrolase, deaminase, fatty acylamidase, and N-acetylaminohydrolase. This enzyme participates in 6 metabolic pathways: urea cycle and metabolism of amino groups, phenylalanine metabolism, tryptophan metabolism, cyanoamino acid metabolism, benzoate degradation via coa ligation, and styrene degradation.

tructural studies

As of late 2007, two structures have been solved for this class of enzymes, with PDB accession codes PDB link|2PLQ and PDB link|2UXY.

References

*
*

External links

::"The CAS registry number for this enzyme class is CAS registry|9012-56-0."

Gene Ontology (GO) codes


Wikimedia Foundation. 2010.

Игры ⚽ Поможем решить контрольную работу

Look at other dictionaries:

  • amidase — amidazė statusas T sritis chemija apibrėžtis Fermentas, katalizuojantis amidinių ryšių hidrolizę. atitikmenys: angl. amidase rus. амидаза …   Chemijos terminų aiškinamasis žodynas

  • amidase — noun Etymology: International Scientific Vocabulary Date: 1921 an enzyme that hydrolyzes acid amides usually with the liberation of ammonia …   New Collegiate Dictionary

  • amidase — /am i days , dayz /, n. Biochem. an enzyme that catalyzes the hydrolysis of an acid amide. [1920 25; AMID + ASE] * * * …   Universalium

  • amidase — noun Any amidohydrolase …   Wiktionary

  • amidase — An enzyme that catalyzes the hydrolysis of monocarboxylic amides to free acid plus NH3; ω a. acts on amides such as α ketoglutaramic acid and α ketosuccinamic acid. * * * am·i·dase am ə .dās, .dāz n an enzyme that hydrolyzes acid amides usu. with …   Medical dictionary

  • Amidase — Ami|da|se 〈f. 19; Chem.〉 Amide spaltendes Enzym [<Amid + ...stase] * * * A|mi|da|se [↑ Amid u. ↑ ase], die; , n; Syn.: Amid Hydrolase: ein die C N Bindung von Säureamiden (↑ Amid) spaltendes Enzym ( …   Universal-Lexikon

  • Amidase — A|mi|da|se 〈f.; Gen.: , Pl.: n; Biochemie〉 Amide spaltendes Enzym [Etym.: <Amid + …stase] …   Lexikalische Deutsches Wörterbuch

  • Amidase — Amida̱se [↑Amid u. ↑...ase] w; , n: Enzym, das Säureamide spaltet …   Das Wörterbuch medizinischer Fachausdrücke

  • Amidase — Ami|da|se die; , n <zu ↑...ase> ↑Enzym, das Säureamide spaltet …   Das große Fremdwörterbuch

  • amidase — n. enzyme that catalyzes hydrolysis of amide …   English contemporary dictionary

Share the article and excerpts

Direct link
Do a right-click on the link above
and select “Copy Link”