Adenine deaminase


Adenine deaminase

In enzymology, an adenine deaminase (EC number|3.5.4.2) is an enzyme that catalyzes the chemical reaction

:adenine + H2O ightleftharpoons hypoxanthine + NH3

Thus, the two substrates of this enzyme are adenine and H2O, whereas its two products are hypoxanthine and NH3.

This enzyme belongs to the family of hydrolases, those acting on carbon-nitrogen bonds other than peptide bonds, specifically in cyclic amidines. The systematic name of this enzyme class is adenine aminohydrolase. Other names in common use include adenase, adenine aminase, and ADase. This enzyme participates in purine metabolism.

tructural studies

As of late 2007, only one structure has been solved for this class of enzymes, with the PDB accession code PDB link|2ICS.

References

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External links

::"The CAS registry number for this enzyme class is CAS registry|9027-68-3."

Gene Ontology (GO) codes


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