Purine nucleosidase

Purine nucleosidase

In enzymology, a purine nucleosidase (EC number|3.2.2.1) is an enzyme that catalyzes the chemical reaction

:a purine nucleoside + H2O ightleftharpoons D-ribose + a purine base

Thus, the two substrates of this enzyme are purine nucleoside and H2O, whereas its two products are D-ribose and purine base.

This enzyme belongs to the family of hydrolases, specifically those glycosylases that hydrolyse N-glycosyl compounds. The systematic name of this enzyme class is purine-nucleoside ribohydrolase. Other names in common use include nucleosidase, purine beta-ribosidase, purine nucleoside hydrolase, purine ribonucleosidase, ribonucleoside hydrolase, nucleoside hydrolase, N-ribosyl purine ribohydrolase, nucleosidase g, N-D-ribosylpurine ribohydrolase, inosine-adenosine-guanosine preferring nucleoside hydrolase, purine-specific nucleoside N-ribohydrolase, IAG-nucleoside hydrolase, and IAG-NH. This enzyme participates in purine metabolism and nicotinate and nicotinamide metabolism.

tructural studies

As of late 2007, 11 structures have been solved for this class of enzymes, with PDB accession codes PDB link|1EZR, PDB link|1HOZ, PDB link|1HP0, PDB link|1KIC, PDB link|1KIE, PDB link|1MAS, PDB link|1R4F, PDB link|2C40, PDB link|2FF1, PDB link|2FF2, and PDB link|2MAS.

References

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External links

::"The CAS registry number for this enzyme class is CAS registry|9025-44-9."

Gene Ontology (GO) codes


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