Phosphoinositide 5-phosphatase

In enzymology, a phosphoinositide 5-phosphatase (EC number|3.1.3.36) is an enzyme that catalyzes the chemical reaction

:1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate + H₂O $ightleftharpoons$ 1-phosphatidyl-1D-myo-inositol 4-phosphate + phosphate

Thus, the two substrates of this enzyme are 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate and H₂O, whereas its two products are 1-phosphatidyl-1D-myo-inositol 4-phosphate and phosphate.

This enzyme belongs to the family of hydrolases, specifically those acting on phosphoric monoester bonds. The systematic name of this enzyme class is phosphatidyl-myo-inositol-4,5-bisphosphate 4-phosphohydrolase. Other names in common use include type II inositol polyphosphate 5-phosphatase, triphosphoinositide phosphatase, IP3 phosphatase, PtdIns(4,5)P2 phosphatase, triphosphoinositide phosphomonoesterase, diphosphoinositide phosphatase, inositol 1,4,5-triphosphate 5-phosphomonoesterase, inositol triphosphate 5-phosphomonoesterase, phosphatidylinositol-bisphosphatase, phosphatidyl-myo-inositol-4,5-bisphosphate phosphatase, phosphatidylinositol 4,5-bisphosphate phosphatase, polyphosphoinositol lipid 5-phosphatase, and phosphatidyl-inositol-bisphosphate phosphatase. This enzyme participates in inositol phosphate metabolism and phosphatidylinositol signaling system.

tructural studies

As of late 2007, 4 structures have been solved for this class of enzymes, with PDB accession codes PDB link|1UFW, PDB link|1W80, PDB link|2DNR, and PDB link|2QV2.

References

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* Cockcroft, S. (Ed.), Biology of Phosphoinositides, Biology of Phosphoinositides, Oxford, 2000, p. 320-338.

External links

::"The CAS registry number for this enzyme class is CAS registry|9036-01-5."

Gene Ontology (GO) codes