N-acetylglucosamine-1-phosphodiester alpha-N-acetylglucosaminidase


N-acetylglucosamine-1-phosphodiester alpha-N-acetylglucosaminidase
N-acetylglucosamine-1-phosphodiester alpha-N-acetylglucosaminidase
Identifiers
EC number 3.1.4.45
CAS number 75788-84-0
Databases
IntEnz IntEnz view
BRENDA BRENDA entry
ExPASy NiceZyme view
KEGG KEGG entry
MetaCyc metabolic pathway
PRIAM profile
PDB structures RCSB PDB PDBe PDBsum
Gene Ontology AmiGO / EGO

In enzymology, a N-acetylglucosamine-1-phosphodiester alpha-N-acetylglucosaminidase (EC 3.1.4.45) is an enzyme that catalyzes the chemical reaction

glycoprotein N-acetyl-D-glucosaminyl-phospho-D-mannose + H2O \rightleftharpoons N-acetyl-D-glucosamine + glycoprotein phospho-D-mannose

Thus, the two substrates of this enzyme are glycoprotein N-acetyl-D-glucosaminyl-phospho-D-mannose and H2O, whereas its two products are N-acetyl-D-glucosamine and glycoprotein phospho-D-mannose.

This enzyme belongs to the family of hydrolases, specifically those acting on phosphoric diester bonds. The systematic name of this enzyme class is glycoprotein-N-acetyl-D-glucosaminyl-phospho-D-mannose N-acetyl-D-glucosaminylphosphohydrolase. Other names in common use include alpha-N-acetylglucosaminyl phosphodiesterase, lysosomal alpha-N-acetylglucosaminidase, phosphodiester glycosidase, alpha-N-acetyl-D-glucosamine-1-phosphodiester, N-acetylglucosaminidase, 2-acetamido-2-deoxy-alpha-D-glucose 1-phosphodiester, and acetamidodeoxyglucohydrolase.

References

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  • van der Drift C, van Helvoort PE, Vogels GD (1971). "S-ureidoglycolate dehydrogenase: purification and properties". Arch. Biochem. Biophys. 145 (2): 465–9. doi:10.1016/S0003-9861(71)80006-1. PMID 4399430. 
  • Van der Drift L, Vogels GD, Van der Drift C (1975). "Allantoin racemase: a new enzyme from Pseudomonas species". Biochim. Biophys. Acta. 391 (1): 240–8. PMID 237557. 
  • Waheed A, Hasilik A, von Figura K (1981). "Processing of the phosphorylated recognition marker in lysosomal enzymes. Characterization and partial purification of a microsomal alpha-N-acetylglucosaminyl phosphodiesterase". J. Biol. Chem. 256 (11): 5717–21. PMID 6263889.