1,4-lactonase

1,4-lactonase

In enzymology, a 1,4-lactonase (EC number|3.1.1.25) is an enzyme that catalyzes the generic chemical reaction:

:a 1,4-lactone + H2O ightleftharpoons a 4-hydroxyacid

Thus, the two substrates of this enzyme are 1,4-lactone and H2O, whereas its product is 4-hydroxyacid.

This enzyme belongs to the family of hydrolases, specifically those acting on carboxylic ester bonds. The systematic name of this enzyme class is 1,4-lactone hydroxyacylhydrolase. This enzyme is also called gamma-lactonase. This enzyme participates in galactose metabolism and ascorbate and aldarate metabolism. It employs one cofactor, calcium.

tructural studies

As of late 2007, three structures have been solved for this class of enzymes, with PDB accession codes PDB link|2DG0, PDB link|2DG1, and PDB link|2DSO.

References

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External links

::"The CAS registry number for this enzyme class is CAS registry|37278-38-9."

Gene Ontology (GO) codes


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