Nucleotide diphosphatase

nucleotide diphosphatase
Identifiers
EC number	3.6.1.9
CAS number	9032-64-8
Databases
IntEnz	IntEnz view
BRENDA	BRENDA entry
ExPASy	NiceZyme view
KEGG	KEGG entry
MetaCyc	metabolic pathway
PRIAM	profile
PDB structures	RCSB PDB PDBe PDBsum
Gene Ontology	AmiGO / EGO
Search PMC articles PubMed articles

In enzymology, a nucleotide diphosphatase (EC 3.6.1.9) is an enzyme that catalyzes the chemical reaction

a dinucleotide + H₂O $\rightleftharpoons$ 2 mononucleotides

Thus, the two substrates of this enzyme are dinucleotide and H₂O, whereas its product is mononucleotide.

This enzyme belongs to the family of hydrolases, specifically those acting on acid anhydrides in phosphorus-containing anhydrides. The systematic name of this enzyme class is dinucleotide nucleotidohydrolase. Other names in common use include nucleotide pyrophosphatase, and nucleotide-sugar pyrophosphatase. This enzyme participates in 5 metabolic pathways: purine metabolism, starch and sucrose metabolism, riboflavin metabolism, nicotinate and nicotinamide metabolism, and pantothenate and coa biosynthesis.

Structural studies

As of late 2007^[update], 5 structures have been solved for this class of enzymes, with PDB accession codes 1NQY, 1NQZ, 2GSN, 2GSO, and 2GSU.

References

• Jacobson JB and Kaplan NO (1957). "A reduced pyridine nucleotide pyrophosphatase". J. Biol. Chem. 226: 427–437. PMID 13428775. 
• Kornberg A and Pricer WE (1950). "Nucleotide pyrophosphatase". J. Biol. Chem. 182: 763–778. 
• Kumar SA, Rao NA, Vaidyanathan CS (1965). "Nucleotidases in plants. I. Partial purification and properties of the enzyme hydrolyzing flavine adenine dinucleotide from mung bean seedlings (Phaseolus radiatus)". Arch. Biochem. Biophys. 111 (3): 646–52. doi:10.1016/0003-9861(65)90246-8. PMID 5862212. 
• Swartz MN, Kaplan NO and Lamborg MF (1958). "A "heat-activated" diphosphopyridine nucleotide pyrophosphatase from Proteus vulgaris". J. Biol. Chem. 232: 1051–1063. PMID 13549486. 

This hydrolase article is a stub. You can help Wikipedia by expanding it.v · Categories: Hydrolase stubs EC 3.6.1 Enzymes of known structure Wikimedia Foundation. 2010. Игры ⚽ Поможем написать реферат Halstead complexity measures Robert Furber Look at other dictionaries: diphosphatase — noun Any enzyme that catalyses the hydrolysis of the diphosphate of a specific nucleotide or other biochemical compound …   Wiktionary Nucleoside-diphosphatase — Identifiers EC number 3.6.1.6 CAS number 9027 69 4 …   Wikipedia Nucleoside-triphosphate diphosphatase — Identifiers EC number 3.6.1.19 CAS number 9075 54 1 …   Wikipedia ADP-ribose diphosphatase — (EC number|3.6.1.13) is an enzyme that catalyzes a hydrolysis reaction in which water nucleophillicly attacks ADP ribose to produce AMP and D ribose 5 phosphate. Enzyme hydrolysis occurs by the breakage of a phosphoanhydride bond and is dependent …   Wikipedia dUTP diphosphatase — Identifiers EC number 3.6.1.23 CAS number 37289 34 2 …   Wikipedia List of EC numbers (EC 3) — This list contains a list of EC numbers for the third group, EC 3, hydrolases, placed in numerical order as determined by the Nomenclature Committee of the International Union of Biochemistry and Molecular Biology.EC 3.1: Acting on Ester BondsEC… …   Wikipedia Hydrolase — Cristal de lysozyme Les hydrolases constituent une classe d enzymes qui catalysent les réactions d hydrolyse de molécules suivant la réaction générale : R R + H2O ⇌ R OH + R H On y trouve par exemple les estérases, qui hydrolysent les …   Wikipédia en Français EC 3.1 — Le groupe EC3.1 est un groupe d hydrolases rassemblant les estérases, c est à dire les enzymes catalysant la réaction générale : R O R + H2O ⇌ R OH + R OH où R représente un acide quelconque et R son substrat. En fonction du milieu, l ester… …   Wikipédia en Français NUDT5 — Nudix (nucleoside diphosphate linked moiety X) type motif 5 PDB rendering based on 2dsb …   Wikipedia metabolism — /meuh tab euh liz euhm/, n. 1. Biol., Physiol. the sum of the physical and chemical processes in an organism by which its material substance is produced, maintained, and destroyed, and by which energy is made available. Cf. anabolism, catabolism …   Universalium 18+ © Academic, 2000-2024 Contact us: Technical Support, Advertising Dictionaries export, created on PHP, Joomla, Drupal, WordPress, MODx. Mark and share Search through all dictionaries Translate… Search Internet Share the article and excerpts Direct link … Do a right-click on the link above and select “Copy Link”