- Fluid compartments
Fluid compartments in the
mammalian body broadly comprise two compartments, each with several subdivisions: intracellular fluid, which makes up approximately 60-65% of body water, and extracellular fluid, which makes up the other 35-40% of body water. (For all practical purposes, the only solventin the body is water) [cite web
title="Body Fluids, Medical Physiology" ]
Intracellular fluidis found inside the bilayered plasma membrane, and is the matrix in which cellular organellesare suspended, and chemical reactionstake place. [W.Kapit ,R.Macey,E.Meisami , "The Physiology Coloring Book 2nd ed" pg 1-7. Addison/Wesley/Longman, Inc.San Francisco ,2000.] The intracellular compartment contains on average about 28 liters of fluid, and under ordinary circumstances remains in osmoticequilibrium with the ECF.
Outside the plasma membrane the cell is continually bathed in
interstitialfluid ,which is the immediate microenvironmentthat allows for movement of ions, proteinsand nutrientsacross the cell barrier. This fluid is not static, but is continally being refreshed and recollected by lymphatic channels. In the average male (70kg)human body, the interstitial space has approximately 11 liters of fluid.
The main intravascular fluid in mammals is
bloodwhich is a complex fluid with elements of a suspension (blood cells), colloid(globulins) and solvent(glucose and ions).The average volume of plasma in the average (70kg) male is approximately 3liters.The volume of the intravascular lumen is regulated in part by hydrostatic pressure gradients,and by readsorbtion by the kidneys.
Intravascular compartmentThe main intravascular fluid in mammals is blood which is a complex fluid with elements of a suspension (blood cells), colloid(globulins) and solvent(glucose and ions).The average volume of plasma in the average (70kg) male is approximately 3 liters.The volume of the intravascular lumen is regulated in part by hydrostatic pressure gradients,and by reabsorbtion by the kidneys.
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