Neurotensin receptor 2

Neurotensin receptor 2
Neurotensin receptor 2
Symbols NTSR2; NTR2
External IDs OMIM605538 MGI108018 HomoloGene7452 IUPHAR: NTS2 GeneCards: NTSR2 Gene
RNA expression pattern
PBB GE NTSR2 206899 at tn.png
More reference expression data
Species Human Mouse
Entrez 23620 18217
Ensembl ENSG00000169006 ENSMUSG00000020591
UniProt O95665 Q8VIF4
RefSeq (mRNA) XM_001129997 NM_008747.2
RefSeq (protein) XP_001129997 NP_032773.2
Location (UCSC) Chr 2:
11.8 – 11.81 Mb
Chr 12:
16.66 – 16.67 Mb
PubMed search [1] [2]

Neurotensin receptor type 2 is a protein that in humans is encoded by the NTSR2 gene.[1][2][3]

The protein encoded by this gene belongs to the G protein-coupled receptor family that activate a phosphatidylinositol-calcium second messenger system. Binding and pharmacological studies demonstrate that this receptor binds neurotensin as well as several other ligands already described for neurotensin NT1 receptor. However, unlike NT1 receptor, this gene recognizes, with high affinity, levocabastine, a histamine H1 receptor antagonist previously shown to compete with neurotensin for low-affinity binding sites in brain. These activities suggest that this receptor may be of physiological importance and that a natural agonist for the receptor may exist.[3]


See also


  1. ^ Chalon P, Vita N, Kaghad M, Guillemot M, Bonnin J, Delpech B, Le Fur G, Ferrara P, Caput D (Jul 1996). "Molecular cloning of a levocabastine-sensitive neurotensin binding site". FEBS Lett 386 (2-3): 91–4. doi:10.1016/0014-5793(96)00397-3. PMID 8647296. 
  2. ^ Vita N, Oury-Donat F, Chalon P, Guillemot M, Kaghad M, Bachy A, Thurneyssen O, Garcia S, Poinot-Chazel C, Casellas P, Keane P, Le Fur G, Maffrand JP, Soubrie P, Caput D, Ferrara P (Feb 1999). "Neurotensin is an antagonist of the human neurotensin NT2 receptor expressed in Chinese hamster ovary cells". Eur J Pharmacol 360 (2-3): 265–72. doi:10.1016/S0014-2999(98)00678-5. PMID 9851594. 
  3. ^ a b "Entrez Gene: NTSR2 neurotensin receptor 2". 

Further reading

Metabolites and
signaling molecules
Class B: Secretin like Class C: Metabotropic
glutamate / pheromone Class F:
Frizzled / Smoothened
B trdu: iter (nrpl/grfl/cytl/horl), csrc (lgic, enzr, gprc, igsr, intg, nrpr/grfr/cytr), itra (adap, gbpr, mapk), calc, lipd; path (hedp, wntp, tgfp+mapp, notp, jakp, fsap, hipp, tlrp)

External links

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