EDG5

EDG5 (endothelial differentiation gene 1) is a human gene which encodes a G protein-coupled receptor which binds the lipid signaling molecule sphingosine 1-phosphate (S1P). Hence this receptor is also known as S1P₂.cite web | title = Entrez Gene: EDG5 endothelial differentiation, sphingolipid G-protein-coupled receptor, 5| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=9294| accessdate = ]

PBB_Summary
section_title =
summary_text = This gene encodes a member of the G protein-coupled receptors, as well as the EDG family of proteins. This protein participates in sphingosine 1-phosphate-induced cell proliferation, survival, and transcriptional activationcite web | title = Entrez Gene: EDG5 endothelial differentiation, sphingolipid G-protein-coupled receptor, 5| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=9294| accessdate = ]

ee also

* Lysophospholipid receptor

References

Further reading

PBB_Further_reading
citations =
*cite journal | author=Spiegel S |title=Sphingosine 1-phosphate: a ligand for the EDG-1 family of G-protein-coupled receptors. |journal=Ann. N. Y. Acad. Sci. |volume=905 |issue= |pages= 54–60 |year= 2000 |pmid= 10818441 |doi=
*cite journal | author=Takuwa Y |title= [Regulation of Rho family G proteins and cell motility by the Edg family of sphingosin 1-phosphate receptors] |journal=Tanpakushitsu Kakusan Koso |volume=47 |issue= 4 Suppl |pages= 496–502 |year= 2002 |pmid= 11915348 |doi=
*cite journal | author=MacLennan AJ, Browe CS, Gaskin AA, "et al." |title=Cloning and characterization of a putative G-protein coupled receptor potentially involved in development. |journal=Mol. Cell. Neurosci. |volume=5 |issue= 3 |pages= 201–9 |year= 1994 |pmid= 8087418 |doi= 10.1006/mcne.1994.1024
*cite journal | author=Yamaguchi F, Tokuda M, Hatase O, Brenner S |title=Molecular cloning of the novel human G protein-coupled receptor (GPCR) gene mapped on chromosome 9. |journal=Biochem. Biophys. Res. Commun. |volume=227 |issue= 2 |pages= 608–14 |year= 1996 |pmid= 8878560 |doi= 10.1006/bbrc.1996.1553
*cite journal | author=Van Brocklyn JR, Tu Z, Edsall LC, "et al." |title=Sphingosine 1-phosphate-induced cell rounding and neurite retraction are mediated by the G protein-coupled receptor H218. |journal=J. Biol. Chem. |volume=274 |issue= 8 |pages= 4626–32 |year= 1999 |pmid= 9988698 |doi=
*cite journal | author=Ancellin N, Hla T |title=Differential pharmacological properties and signal transduction of the sphingosine 1-phosphate receptors EDG-1, EDG-3, and EDG-5. |journal=J. Biol. Chem. |volume=274 |issue= 27 |pages= 18997–9002 |year= 1999 |pmid= 10383399 |doi=
*cite journal | author=Windh RT, Lee MJ, Hla T, "et al." |title=Differential coupling of the sphingosine 1-phosphate receptors Edg-1, Edg-3, and H218/Edg-5 to the G(i), G(q), and G(12) families of heterotrimeric G proteins. |journal=J. Biol. Chem. |volume=274 |issue= 39 |pages= 27351–8 |year= 1999 |pmid= 10488065 |doi=
*cite journal | author=An S, Zheng Y, Bleu T |title=Sphingosine 1-phosphate-induced cell proliferation, survival, and related signaling events mediated by G protein-coupled receptors Edg3 and Edg5. |journal=J. Biol. Chem. |volume=275 |issue= 1 |pages= 288–96 |year= 2000 |pmid= 10617617 |doi=
*cite journal | author=Himmel HM, Meyer Zu Heringdorf D, Graf E, "et al." |title=Evidence for Edg-3 receptor-mediated activation of I(K.ACh) by sphingosine-1-phosphate in human atrial cardiomyocytes. |journal=Mol. Pharmacol. |volume=58 |issue= 2 |pages= 449–54 |year= 2000 |pmid= 10908314 |doi=
*cite journal | author=Hla T |title=Sphingosine 1-phosphate receptors. |journal= |volume=64 |issue= 1-4 |pages= 135–142 |year= |pmid= 11331101 |doi=
*cite journal | author=Mazurais D, Robert P, Gout B, "et al." |title=Cell type-specific localization of human cardiac S1P receptors. |journal=J. Histochem. Cytochem. |volume=50 |issue= 5 |pages= 661–70 |year= 2002 |pmid= 11967277 |doi=
*cite journal | author=Osada M, Yatomi Y, Ohmori T, "et al." |title=Enhancement of sphingosine 1-phosphate-induced migration of vascular endothelial cells and smooth muscle cells by an EDG-5 antagonist. |journal=Biochem. Biophys. Res. Commun. |volume=299 |issue= 3 |pages= 483–7 |year= 2003 |pmid= 12445827 |doi=
*cite journal | author=Strausberg RL, Feingold EA, Grouse LH, "et al." |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899
*cite journal | author=Vogler R, Sauer B, Kim DS, "et al." |title=Sphingosine-1-phosphate and its potentially paradoxical effects on critical parameters of cutaneous wound healing. |journal=J. Invest. Dermatol. |volume=120 |issue= 4 |pages= 693–700 |year= 2003 |pmid= 12648236 |doi= 10.1046/j.1523-1747.2003.12096.x
*cite journal | author=Kaneider NC, Lindner J, Feistritzer C, "et al." |title=The immune modulator FTY720 targets sphingosine-kinase-dependent migration of human monocytes in response to amyloid beta-protein and its precursor. |journal=FASEB J. |volume=18 |issue= 11 |pages= 1309–11 |year= 2005 |pmid= 15208267 |doi= 10.1096/fj.03-1050fje
*cite journal | author=Gerhard DS, Wagner L, Feingold EA, "et al." |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121–7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504
*cite journal | author=Sanchez T, Thangada S, Wu MT, "et al." |title=PTEN as an effector in the signaling of antimigratory G protein-coupled receptor. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=102 |issue= 12 |pages= 4312–7 |year= 2005 |pmid= 15764699 |doi= 10.1073/pnas.0409784102
*cite journal | author=Sanchez T, Skoura A, Wu MT, "et al." |title=Induction of vascular permeability by the sphingosine-1-phosphate receptor-2 (S1P2R) and its downstream effectors ROCK and PTEN. |journal=Arterioscler. Thromb. Vasc. Biol. |volume=27 |issue= 6 |pages= 1312–8 |year= 2007 |pmid= 17431187 |doi= 10.1161/ATVBAHA.107.143735

External links

* [http://www.iuphar-db.org/GPCR/ChapterMenuForward?chapterID=1338 IUPHAR GPCR Database - Lysophospholipid receptors]
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