Glucarate dehydratase

In enzymology, a glucarate dehydratase (EC number|4.2.1.40) is an enzyme that catalyzes the chemical reaction

:D-glucarate $ightleftharpoons$ 5-dehydro-4-deoxy-D-glucarate + H₂O

Hence, this enzyme has one substrate, D-glucarate, and two products, 5-dehydro-4-deoxy-D-glucarate and H₂O.

This enzyme belongs to the family of lyases, specifically the hydro-lyases, which cleave carbon-oxygen bonds. The systematic name of this enzyme class is D-glucarate hydro-lyase (5-dehydro-4-deoxy-D-glucarate-forming). Other names in common use include D-glucarate dehydratase, and D-glucarate hydro-lyase. This enzyme participates in ascorbate and aldarate metabolism.

tructural studies

As of late 2007, 7 structures have been solved for this class of enzymes, with PDB accession codes PDB link|1BQG, PDB link|1EC7, PDB link|1EC8, PDB link|1EC9, PDB link|1ECQ, PDB link|1JCT, and PDB link|1JDF.

References

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External links

::"The CAS registry number for this enzyme class is CAS registry|9059-02-3."

Gene Ontology (GO) codes