The alpha-2A adrenergic receptor (α2A adrenoreceptor), also known as ADRA2A, is an alpha-2 adrenergic receptor, and also denotes the human gene encoding it.
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Receptor
Alpha-2-adrenergic receptors include 3 highly homologous subtypes: alpha2A, alpha2B, and alpha2C. These receptors have a critical role in regulating neurotransmitter release from sympathetic nerves and from adrenergic neurons in the central nervous system. Studies in mouse revealed that both the alpha2A and alpha2C subtypes were required for normal presynaptic control of transmitter release from sympathetic nerves in the heart and from central noradrenergic neurons; the alpha2A subtype inhibited transmitter release at high stimulation frequencies, whereas the alpha2C subtype modulated neurotransmission at lower levels of nerve activity.
Gene
This gene encodes alpha2A subtype and it contains no introns in either its coding or untranslated sequences.[cite web | title = Entrez Gene: ADRA2A adrenergic, alpha-2A-, receptor| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=150| accessdate = ] ]ee also
*Adrenergic receptor
References
Further reading
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citations =
*cite journal | author=Perälä M, Hirvonen H, Kalimo H, "et al." |title=Differential expression of two alpha 2-adrenergic receptor subtype mRNAs in human tissues. |journal=Brain Res. Mol. Brain Res. |volume=16 |issue= 1-2 |pages= 57–63 |year= 1993 |pmid= 1334200 |doi=
*cite journal | author=Surprenant A, Horstman DA, Akbarali H, Limbird LE |title=A point mutation of the alpha 2-adrenoceptor that blocks coupling to potassium but not calcium currents. |journal=Science |volume=257 |issue= 5072 |pages= 977–80 |year= 1992 |pmid= 1354394 |doi=
*cite journal | author=Handy DE, Gavras H |title=Promoter region of the human alpha 2A adrenergic receptor gene. |journal=J. Biol. Chem. |volume=267 |issue= 33 |pages= 24017–22 |year= 1992 |pmid= 1385431 |doi=
*cite journal | author=Suryanarayana S, Daunt DA, Von Zastrow M, Kobilka BK |title=A point mutation in the seventh hydrophobic domain of the alpha 2 adrenergic receptor increases its affinity for a family of beta receptor antagonists. |journal=J. Biol. Chem. |volume=266 |issue= 23 |pages= 15488–92 |year= 1991 |pmid= 1678390 |doi=
*cite journal | author=Wang CD, Buck MA, Fraser CM |title=Site-directed mutagenesis of alpha 2A-adrenergic receptors: identification of amino acids involved in ligand binding and receptor activation by agonists. |journal=Mol. Pharmacol. |volume=40 |issue= 2 |pages= 168–79 |year= 1991 |pmid= 1678850 |doi=
*cite journal | author=Chhajlani V, Rangel N, Uhlén S, Wikberg JE |title=Identification of an additional gene belonging to the alpha 2 adrenergic receptor family in the human genome by PCR. |journal=FEBS Lett. |volume=280 |issue= 2 |pages= 241–4 |year= 1991 |pmid= 1849485 |doi=
*cite journal | author=Guyer CA, Horstman DA, Wilson AL, "et al." |title=Cloning, sequencing, and expression of the gene encoding the porcine alpha 2-adrenergic receptor. Allosteric modulation by Na+, H+, and amiloride analogs. |journal=J. Biol. Chem. |volume=265 |issue= 28 |pages= 17307–17 |year= 1990 |pmid= 2170371 |doi=
*cite journal | author=Fraser CM, Arakawa S, McCombie WR, Venter JC |title=Cloning, sequence analysis, and permanent expression of a human alpha 2-adrenergic receptor in Chinese hamster ovary cells. Evidence for independent pathways of receptor coupling to adenylate cyclase attenuation and activation. |journal=J. Biol. Chem. |volume=264 |issue= 20 |pages= 11754–61 |year= 1989 |pmid= 2568356 |doi=
*cite journal | author=Kobilka BK, Matsui H, Kobilka TS, "et al." |title=Cloning, sequencing, and expression of the gene coding for the human platelet alpha 2-adrenergic receptor. |journal=Science |volume=238 |issue= 4827 |pages= 650–6 |year= 1987 |pmid= 2823383 |doi=
*cite journal | author=Lynch CJ, Steer ML |title=Evidence for high and low affinity alpha 2-receptors. Comparison of [3H] norepinephrine and [3H] phentolamine binding to human platelet membranes. |journal=J. Biol. Chem. |volume=256 |issue= 7 |pages= 3298–303 |year= 1981 |pmid= 6259160 |doi=
*cite journal | author=Eason MG, Moreira SP, Liggett SB |title=Four consecutive serines in the third intracellular loop are the sites for beta-adrenergic receptor kinase-mediated phosphorylation and desensitization of the alpha 2A-adrenergic receptor. |journal=J. Biol. Chem. |volume=270 |issue= 9 |pages= 4681–8 |year= 1995 |pmid= 7876239 |doi=
*cite journal | author=Grassie MA, Milligan G |title=Analysis of the relative interactions between the alpha 2C10 adrenoceptor and the guanine-nucleotide-binding proteins G(o)1 alpha and Gi 2 alpha following co-expression of these polypeptides in rat 1 fibroblasts. |journal=Biochem. J. |volume=306 ( Pt 2) |issue= |pages= 525–30 |year= 1995 |pmid= 7887906 |doi=
*cite journal | author=Shilo L, Sakaue M, Thomas JM, "et al." |title=Enhanced transcription of the human alpha 2A-adrenergic receptor gene by cAMP: evidence for multiple cAMP responsive sequences in the promoter region of this gene. |journal=Cell. Signal. |volume=6 |issue= 1 |pages= 73–82 |year= 1994 |pmid= 8011430 |doi=
*cite journal | author=Valet P, Senard JM, Devedjian JC, "et al." |title=Characterization and distribution of alpha 2-adrenergic receptors in the human intestinal mucosa. |journal=J. Clin. Invest. |volume=91 |issue= 5 |pages= 2049–57 |year= 1993 |pmid= 8098045 |doi=
*cite journal | author=Alblas J, van Corven EJ, Hordijk PL, "et al." |title=Gi-mediated activation of the p21ras-mitogen-activated protein kinase pathway by alpha 2-adrenergic receptors expressed in fibroblasts. |journal=J. Biol. Chem. |volume=268 |issue= 30 |pages= 22235–8 |year= 1993 |pmid= 8226727 |doi=
*cite journal | author=Klein U, Ramirez MT, Kobilka BK, von Zastrow M |title=A novel interaction between adrenergic receptors and the alpha-subunit of eukaryotic initiation factor 2B. |journal=J. Biol. Chem. |volume=272 |issue= 31 |pages= 19099–102 |year= 1997 |pmid= 9235896 |doi=
*cite journal | author=Bétuing S, Daviaud D, Pagès C, "et al." |title=Gbeta gamma-independent coupling of alpha2-adrenergic receptor to p21(rhoA) in preadipocytes. |journal=J. Biol. Chem. |volume=273 |issue= 25 |pages= 15804–10 |year= 1998 |pmid= 9624180 |doi=
*cite journal | author=Prezeau L, Richman JG, Edwards SW, Limbird LE |title=The zeta isoform of 14-3-3 proteins interacts with the third intracellular loop of different alpha2-adrenergic receptor subtypes. |journal=J. Biol. Chem. |volume=274 |issue= 19 |pages= 13462–9 |year= 1999 |pmid= 10224112 |doi=
*cite journal | author=Hein L, Altman JD, Kobilka BK |title=Two functionally distinct alpha2-adrenergic receptors regulate sympathetic neurotransmission. |journal=Nature |volume=402 |issue= 6758 |pages= 181–4 |year= 2000 |pmid= 10647009 |doi= 10.1038/46040
*cite journal | author=Schaak S, Cussac D, Cayla C, "et al." |title=Alpha(2) adrenoceptors regulate proliferation of human intestinal epithelial cells. |journal=Gut |volume=47 |issue= 2 |pages= 242–50 |year= 2000 |pmid= 10896916 |doi=
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