Alpha-2B adrenergic receptor

The alpha-2B adrenergic receptor (α_2B adrenoreceptor), also known as ADRA2B, is an alpha-2 adrenergic receptor, and also denotes the human gene encoding it.

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Receptor

Alpha-2-adrenergic receptors include 3 highly homologous subtypes: alpha_2A, alpha_2B, and alpha_2C. These receptors have a critical role in regulating neurotransmitter release from sympathetic nerves and from adrenergic neurons in the central nervous system.

Gene

This gene encodes the alpha_2B subtype, which was observed to associate with eIF-2B, a guanine nucleotide exchange protein that functions in regulation of translation. A polymorphic variant of the alpha_2B subtype, which lacks 3 glutamic acids from a glutamic acid repeat element, was identified to have decreased G protein-coupled receptor kinase-mediated phosphorylation and desensitization; this polymorphic form is also associated with reduced basal metabolic rate in obese subjects and may therefore contribute to the pathogenesis of obesity. This gene contains no introns in either its coding or untranslated sequences.cite web | title = Entrez Gene: ADRA2B adrenergic, alpha-2B-, receptor| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=151| accessdate = ]

ee also

*Adrenergic receptor

References

Further reading

PBB_Further_reading
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*cite journal | author=Lomasney JW, Lorenz W, Allen LF, "et al." |title=Expansion of the alpha 2-adrenergic receptor family: cloning and characterization of a human alpha 2-adrenergic receptor subtype, the gene for which is located on chromosome 2. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=87 |issue= 13 |pages= 5094–8 |year= 1990 |pmid= 2164221 |doi=
*cite journal | author=McClue SJ, Milligan G |title=The alpha 2B adrenergic receptor of undifferentiated neuroblastoma x glioma hybrid NG108-15 cells, interacts directly with the guanine nucleotide binding protein, Gi2. |journal=FEBS Lett. |volume=269 |issue= 2 |pages= 430–4 |year= 1990 |pmid= 2169434 |doi=
*cite journal | author=Weinshank RL, Zgombick JM, Macchi M, "et al." |title=Cloning, expression, and pharmacological characterization of a human alpha 2B-adrenergic receptor. |journal=Mol. Pharmacol. |volume=38 |issue= 5 |pages= 681–8 |year= 1990 |pmid= 2172775 |doi=
*cite journal | author=Chang AC, Ho TF, Chang NC |title=In vitro amplification by polymerase chain reaction of a partial gene encoding the third subtype of alpha-2 adrenergic receptor in humans. |journal=Biochem. Biophys. Res. Commun. |volume=172 |issue= 2 |pages= 817–23 |year= 1990 |pmid= 2173582 |doi=
*cite journal | author=Regan JW, Kobilka TS, Yang-Feng TL, "et al." |title=Cloning and expression of a human kidney cDNA for an alpha 2-adrenergic receptor subtype. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=85 |issue= 17 |pages= 6301–5 |year= 1988 |pmid= 2842764 |doi=
*cite journal | author=Petrash AC, Bylund DB |title=Alpha-2 adrenergic receptor subtypes indicated by [3H] yohimbine binding in human brain. |journal=Life Sci. |volume=38 |issue= 23 |pages= 2129–37 |year= 1986 |pmid= 3012234 |doi=
*cite journal | author=Klein U, Ramirez MT, Kobilka BK, von Zastrow M |title=A novel interaction between adrenergic receptors and the alpha-subunit of eukaryotic initiation factor 2B. |journal=J. Biol. Chem. |volume=272 |issue= 31 |pages= 19099–102 |year= 1997 |pmid= 9235896 |doi=
*cite journal | author=Okusa MD, Huang L, Momose-Hotokezaka A, "et al." |title=Regulation of adenylyl cyclase in polarized renal epithelial cells by G protein-coupled receptors. |journal=Am. J. Physiol. |volume=273 |issue= 6 Pt 2 |pages= F883–91 |year= 1998 |pmid= 9435676 |doi=
*cite journal | author=Prezeau L, Richman JG, Edwards SW, Limbird LE |title=The zeta isoform of 14-3-3 proteins interacts with the third intracellular loop of different alpha2-adrenergic receptor subtypes. |journal=J. Biol. Chem. |volume=274 |issue= 19 |pages= 13462–9 |year= 1999 |pmid= 10224112 |doi=
*cite journal | author=Heinonen P, Koulu M, Pesonen U, "et al." |title=Identification of a three-amino acid deletion in the alpha2B-adrenergic receptor that is associated with reduced basal metabolic rate in obese subjects. |journal=J. Clin. Endocrinol. Metab. |volume=84 |issue= 7 |pages= 2429–33 |year= 1999 |pmid= 10404816 |doi=
*cite journal | author=Hein L, Altman JD, Kobilka BK |title=Two functionally distinct alpha2-adrenergic receptors regulate sympathetic neurotransmission. |journal=Nature |volume=402 |issue= 6758 |pages= 181–4 |year= 2000 |pmid= 10647009 |doi= 10.1038/46040
*cite journal | author=Small KM, Brown KM, Forbes SL, Liggett SB |title=Polymorphic deletion of three intracellular acidic residues of the alpha 2B-adrenergic receptor decreases G protein-coupled receptor kinase-mediated phosphorylation and desensitization. |journal=J. Biol. Chem. |volume=276 |issue= 7 |pages= 4917–22 |year= 2001 |pmid= 11056163 |doi= 10.1074/jbc.M008118200
*cite journal | author=Snapir A, Mikkelsson J, Perola M, "et al." |title=Variation in the alpha2B-adrenoceptor gene as a risk factor for prehospital fatal myocardial infarction and sudden cardiac death. |journal=J. Am. Coll. Cardiol. |volume=41 |issue= 2 |pages= 190–4 |year= 2003 |pmid= 12535806 |doi=
*cite journal | author=Sykiotis GP, Polyzogopoulou E, Georgopoulos NA, "et al." |title=The alpha2B adrenergic receptor deletion/insertion polymorphism in morbid obesity. |journal=Clin. Auton. Res. |volume=13 |issue= 3 |pages= 203–7 |year= 2004 |pmid= 12822042 |doi= 10.1007/s10286-003-0087-5
*cite journal | author=Chotani MA, Mitra S, Su BY, "et al." |title=Regulation of alpha(2)-adrenoceptors in human vascular smooth muscle cells. |journal=Am. J. Physiol. Heart Circ. Physiol. |volume=286 |issue= 1 |pages= H59–67 |year= 2004 |pmid= 12946937 |doi= 10.1152/ajpheart.00268.2003
*cite journal | author=Von Wowern F, Bengtsson K, Lindblad U, "et al." |title=Functional variant in the (alpha)2B adrenoceptor gene, a positional candidate on chromosome 2, associates with hypertension. |journal=Hypertension |volume=43 |issue= 3 |pages= 592–7 |year= 2004 |pmid= 14744925 |doi= 10.1161/01.HYP.0000116224.51189.80
*cite journal | author=Cayla C, Heinonen P, Viikari L, "et al." |title=Cloning, characterisation and identification of several polymorphisms in the promoter region of the human alpha2B-adrenergic receptor gene. |journal=Biochem. Pharmacol. |volume=67 |issue= 3 |pages= 469–78 |year= 2004 |pmid= 15037199 |doi= 10.1016/j.bcp.2003.09.029
*cite journal | author=Phares DA, Halverstadt AA, Shuldiner AR, "et al." |title=Association between body fat response to exercise training and multilocus ADR genotypes. |journal=Obes. Res. |volume=12 |issue= 5 |pages= 807–15 |year= 2004 |pmid= 15166301 |doi=
*cite journal | author=Siitonen N, Lindström J, Eriksson J, "et al." |title=Association between a deletion/insertion polymorphism in the alpha2B-adrenergic receptor gene and insulin secretion and Type 2 diabetes. The Finnish Diabetes Prevention Study. |journal=Diabetologia |volume=47 |issue= 8 |pages= 1416–24 |year= 2005 |pmid= 15309292 |doi= 10.1007/s00125-004-1462-z
*cite journal | author=Belfer I, Buzas B, Hipp H, "et al." |title=Haplotype-based analysis of alpha 2A, 2B, and 2C adrenergic receptor genes captures information on common functional loci at each gene. |journal=J. Hum. Genet. |volume=50 |issue= 1 |pages= 12–20 |year= 2005 |pmid= 15592690 |doi= 10.1007/s10038-004-0211-y

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