Valine-tRNA ligase


Valine-tRNA ligase

In enzymology, a valine-tRNA ligase (EC number|6.1.1.9) is an enzyme that catalyzes the chemical reaction

:ATP + L-valine + tRNAVal ightleftharpoons AMP + diphosphate + L-valyl-tRNAVal

The 3 substrates of this enzyme are ATP, L-valine, and tRNA(Val), whereas its 3 products are AMP, diphosphate, and L-valyl-tRNA(Val).

This enzyme belongs to the family of ligases, specifically those forming carbon-oxygen bonds in aminoacyl-tRNA and related compounds. The systematic name of this enzyme class is L-valine:tRNAVal ligase (AMP-forming). Other names in common use include valyl-tRNA synthetase, valyl-transfer ribonucleate synthetase, valyl-transfer RNA synthetase, valyl-transfer ribonucleic acid synthetase, valine transfer ribonucleate ligase, and valine translase. This enzyme participates in valine, leucine and isoleucine biosynthesis and aminoacyl-trna biosynthesis.

tructural studies

As of late 2007, 5 structures have been solved for this class of enzymes, with PDB accession codes PDB link|1GAX, PDB link|1IVS, PDB link|1IYW, PDB link|1WK9, and PDB link|1WKA.

References

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External links

::"The CAS registry number for this enzyme class is CAS registry|9023-47-6."

Gene Ontology (GO) codes


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