Tryptophan-tRNA ligase


Tryptophan-tRNA ligase

In enzymology, a tryptophan-tRNA ligase (EC number|6.1.1.2) is an enzyme that catalyzes the chemical reaction

:ATP + L-tryptophan + tRNATrp ightleftharpoons AMP + diphosphate + L-tryptophyl-tRNATrp

The 3 substrates of this enzyme are ATP, L-tryptophan, and tRNA(Trp), whereas its 3 products are AMP, diphosphate, and L-tryptophyl-tRNATrp.

This enzyme belongs to the family of ligases, specifically those forming carbon-oxygen bonds in aminoacyl-tRNA and related compounds. The systematic name of this enzyme class is L-tryptophan:tRNATrp ligase (AMP-forming). Other names in common use include tryptophanyl-tRNA synthetase, L-tryptophan-tRNATrp ligase (AMP-forming), tryptophanyl-transfer ribonucleate synthetase, tryptophanyl-transfer ribonucleic acid synthetase, tryptophanyl-transfer RNA synthetase, tryptophanyl ribonucleic synthetase, tryptophanyl-transfer ribonucleic synthetase, tryptophanyl-tRNA synthase, tryptophan translase, and TrpRS. This enzyme participates in tryptophan metabolism and aminoacyl-trna biosynthesis.

tructural studies

As of late 2007, 21 structures have been solved for this class of enzymes, with PDB accession codes PDB link|1D2R, PDB link|1I6K, PDB link|1I6L, PDB link|1I6M, PDB link|1M83, PDB link|1MAU, PDB link|1MAW, PDB link|1MB2, PDB link|1O5T, PDB link|1R6T, PDB link|1R6U, PDB link|1ULH, PDB link|1YIA, PDB link|1YID, PDB link|2A4M, PDB link|2AKE, PDB link|2AZX, PDB link|2DR2, PDB link|2G36, PDB link|2IP1, and PDB link|2OV4.

References

*
*
*

External links

::"The CAS registry number for this enzyme class is CAS registry|9023-44-3."

Gene Ontology (GO) codes


Wikimedia Foundation. 2010.

Look at other dictionaries:

  • Cysteine—tRNA ligase — Identifiers EC number 6.1.1.16 CAS number 37318 56 2 …   Wikipedia

  • Phenylalanine-tRNA ligase — In enzymology, a phenylalanine tRNA ligase (EC number|6.1.1.20) is an enzyme that catalyzes the chemical reaction:ATP + L phenylalanine + tRNAPhe ightleftharpoons AMP + diphosphate + L phenylalanyl tRNAPheThe 3 substrates of this enzyme are ATP,… …   Wikipedia

  • Tyrosine-tRNA ligase — In enzymology, a tyrosine tRNA ligase (EC number|6.1.1.1) is an enzyme that catalyzes the chemical reaction:ATP + L tyrosine + RNA ightleftharpoons AMP + triphosphate + L tyrosyl tRNATyrThe 3 substrates of this enzyme are ATP, L tyrosine, and RNA …   Wikipedia

  • D-alanine—poly(phosphoribitol) ligase — Identifiers EC number 6.1.1.13 CAS number 9023 65 8 …   Wikipedia

  • List of EC numbers (EC 6) — This list contains a list of EC numbers for the sixth group, EC 6, ligases, placed in numerical order as determined by the Nomenclature Committee of the International Union of Biochemistry and Molecular Biology.EC 6.1: Forming Carbon Oxygen… …   Wikipedia

  • Dihydrolipoyl transacetylase — dihydrolipoyllysine residue acetyltransferase Atomic structure of a single subunit of dihydrolipoyl transacetylase from Azotobacter vinelandii that makes up the structural core of the pyruvate dehydrogenase multienzyme complex.[1] …   Wikipedia

  • List of EC numbers (EC 2) — This list contains a list of EC numbers for the second group, EC 2, transferases, placed in numerical order as determined by the Nomenclature Committee of the International Union of Biochemistry and Molecular Biology.EC 2.1: Transferring One… …   Wikipedia

  • Mdm2 — p53 binding protein homolog (mouse) Solution structure of Mdm2. [1] …   Wikipedia

  • metabolism — /meuh tab euh liz euhm/, n. 1. Biol., Physiol. the sum of the physical and chemical processes in an organism by which its material substance is produced, maintained, and destroyed, and by which energy is made available. Cf. anabolism, catabolism …   Universalium

  • Cullin — structure of the cul1 rbx1 skp1 f boxskp2 scf ubiquitin ligase complex Identifiers Symbol Cullin Pfam …   Wikipedia


Share the article and excerpts

Direct link
Do a right-click on the link above
and select “Copy Link”

We are using cookies for the best presentation of our site. Continuing to use this site, you agree with this.