Threonine-tRNA ligase


Threonine-tRNA ligase

In enzymology, a threonine-tRNA ligase (EC number|6.1.1.3) is an enzyme that catalyzes the chemical reaction

:ATP + L-threonine + tRNAThr ightleftharpoons AMP + diphosphate + L-threonyl-tRNAThr

The 3 substrates of this enzyme are ATP, L-threonine, and tRNA(Thr), whereas its 3 products are AMP, diphosphate, and L-threonyl-tRNA(Thr).

This enzyme belongs to the family of ligases, specifically those forming carbon-oxygen bonds in aminoacyl-tRNA and related compounds. The systematic name of this enzyme class is L-threonine:tRNAThr ligase (AMP-forming). Other names in common use include threonyl-tRNA synthetase, threonyl-transfer ribonucleate synthetase, threonyl-transfer RNA synthetase, threonyl-transfer ribonucleic acid synthetase, threonyl ribonucleic synthetase, threonine-transfer ribonucleate synthetase, threonine translase, threonyl-tRNA synthetase, and TRS. This enzyme participates in glycine, serine and threonine metabolism and aminoacyl-trna biosynthesis.

tructural studies

As of late 2007, 17 structures have been solved for this class of enzymes, with PDB accession codes PDB link|1EVK, PDB link|1EVL, PDB link|1FYF, PDB link|1KOG, PDB link|1NYQ, PDB link|1NYR, PDB link|1QF6, PDB link|1TJE, PDB link|1TKE, PDB link|1TKG, PDB link|1TKY, PDB link|1WWT, PDB link|1Y2Q, PDB link|2HKZ, PDB link|2HL0, PDB link|2HL1, and PDB link|2HL2.

References

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External links

::"The CAS registry number for this enzyme class is CAS registry|9023-46-5."

Gene Ontology (GO) codes


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